Expression of a mutant opsin gene increases the susceptibility of the retina to light damage

Visual Neuroscience

Volumn 14, Issue 1, 1997, Pages 55-62

  Wang, Min ^a   Lam, Tim T ^a   Tso, Mark O M ^a,b   Naash, Muna I ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b HONG KONG EYE HOSPITAL   (Hong Kong)

Author keywords

Animal model; Autosomal dominant retinitis pigmentosa; Light damage; Mutant opsin; Transgenic mice

Indexed keywords

EID: 0030808480     PISSN: 09525238     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0952523800008750     Document Type: Article

References (43)

1. At.-UBAIDI, M.R., PITTLER, S.J., CHAMPAGNE, M.S., TRIANTAFYLLOS, J.T., MCGINNIS, J.F. & BAEHR, W. (1990). Mouse opsin. Gene structure and molecular basis of multiple transcripts. Journal of Biological Chemistry 265, 20563-20569.
2. BAEHR, W., FALK, I.D., BUGRA, K., TRIANIAFYLLOS, J.T. & MCGINNIS, J.F. (1988). Isolation and molecular analysis of the mouse opsin gene. FEBS Letters 238, 253-256.
3. BERSON, E.L. (1971). Light deprivation for early retinitis pigmentosa: A hypothesis. Archives of Ophthalmology 85, 521-529.
4. BERSON, E.L. (1980). Light deprivation and relinitis pigmentosa. Vision Research 20, 1179-1184.
5. BERSON, E.L., ROSNER, B., SANDBERG, M.A. & DRYJA, T.P. (1991). Ocular findings in patients with autosomal dominant retinitis pigmentosa and a rhodopsin gene defect (Pro-23-His). Archives of Ophthalmology 109, 92-101.
6. BERSON, E.L. (1993). Retinitis pigmentosa. Investigative Ophthalmology and Visual Science 34, 1659-1676.
7. BIRCH, D.G., HOOD, D.C., NUSINOWITZ, S. & PEPPERBERG, D.R. (1995). Abnormal activation and inactivation mechanisms of rod transducin in patients with autosomal dominant retinitis pigmentosa and the Pro-23-His mutation. Investigative Ophthalmology and Visual Science 36, 1603-1614.
8. CHENG, T. & NAASH, M.I. (1995). Quantitative analysis of mRNA levels of the transgenic and endogenous opsin genes in retinas of transgenic mice. Investigative Ophthalmology and Visual Science 36, S273.
9. CRITCHETT, A. (1919). A biotrophy of the retinal neurocpithelium or 'retinitis pigmentosa.' Transactions of the Ophthalmological Society (U.K.) 49, 165-195.
10. DRYJA, T.P, HAHN, L.B., COWLEY, G.S., McGEF, T.L. & BERSON, E.L. (1991). Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the U.S.A. 88, 9370-9374.
11. GINSBERG, H.M. & LAVAIL, M.M. (1985). Light-induced retinal degeneration in the mouse: Analysis of pigmentation mutants. In Retinal Degeneration: Experimental and Clinical Studies, ed. LAVAIL., M.M., HOLLYFIELD, J.G. & ANDERSON, R.E., pp. 449-469 New York: Alan R. Liss, Inc.
12. Goro, Y., PEACHEY, N.S., RIPPS, H. & NAASH, M.I. (1995) Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene. Investigative Ophthalmology and Visual Science 36, 62-71.
13. GOTO, Y, PEACHEY, N.S., ZIROLI, N.S., SEIPLE, W.H., GRYCZAN, C., PEPPERBERG, D.R. & NAASH, M.I. (1996) Rod phototransduction in transgenic mice expressing a mutant opsin gene. Journal Optical Society of America A 13, 577-585.
14. GRYCZAN, C., KUSZAK, J.R., NOVAK, L., PEACHEY, N.S., GOTO, Y. & NAASH, M.I. (1995). A transgenic mouse model for autosomal dominant retinitis pigmentosa caused by a three base pair deletion in codon 255/256 of the opsin gene. Investigative Ophthalmology and Visual Science (Abstract) 36, S423.
15. HECKENLIVELY, J.R., RODRIGUEZ, J.A. & DAIGER, S.P. (1991). Autosomal dominant sectoral retinitis pigmentosa. Archives of Ophthalmology 109, 84-91.
16. KEMP, C.M., JACOBSON, S.G., ROMAN, A.J., SUNG, C. & NATHANS, J. (1992). Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. American Journal of Ophthalmology 113, 165-174.
17. LAMB, T.D. (1990). Dark adaptation: A re-examination. In Night Vision, ed. HESS, R.F. & NORDBY, L.T., pp. 177-222. Cambridge, Massachusetts: Cambridge University Press.
18. LAVAIL, M.M., GORRIN, G.M., GINSBERG, H.M., THOMAS, L. & HENDERSON, M. (1986). Evidence for genetic regulation of light damage. Investigative Ophthalmology and Visual Science 27, 55
19. LAVAIL, M.M., GORRIN, G.M. & REPACI, M.A. (1987). Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice. Current Eye Research 6, 825-834.
20. LAVAIL, M.M., WHITE, M.P., GORRIN, G.M., YASUMURA, D., PORRELLO, K.V. & MULLEN, R.J. (1993). Retinal degeneration in the nervous mutant mouse. I. Light microscopic cytopathology and changes in the interphotoreceptor matrix. Journal of Comparative Neurology 333, 168-181.
21. LEBER, T. (1916). Die pigmentdegeneration der netzhaut und mit ihr verwandte erkrankungen. In Handbuch der Gesamten Augenheilkunde, ed. SAEMISCH-HESS, G., vol. 7, pp. 1076-1225. Leipzig, West Germany: Engelmann.
22. LI, T., FRANSON, W.K., GORDON, J.W., BERSON, E.L. & DRYJA, T.P. (1995). Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration. Proceedings of the National Academy of Sciences of the U.S.A. 92, 3551-3555.
23. Li, Z., JACOBSON, S.G. & MILAM, A.H. (1994). Autosomal dominant retinitis pigmentosa caused by the threonine-17-methionine rhodopsin mutation: Retinal histopathology and immunocytochemistry. Experimental Eye Research 58, 397-408.
24. MIYAKE, Y, SUGITA, S., HORIGUCHI, M. & YAGASAKI, K. (1990). Light deprivation and retinitis pigmentosa. American Journal of Ophthalmology 110, 305-306.
25. NAASH, M.I., LAVAIL, M.M. & ANDERSON, R.E. (1989). Factors affecting the susceptibility of the retina to light damage. In Inherited and Environmentally Induced Retinal Degenerations, ed. LAVAIL, M.M., ANDERSON, R.E. & HOLLYFIELD, J.G., pp. 513-522. New York: Alan R. Liss.
26. NAASH, M.I., AL-UBAIDI, M.R., HOLLYFIELD, J.G. & BAEHR, W. (1993a) Simulation of autosomal dominant retinitis pigmentosa in transgenic mice. In Retinal Degeneration, ed. HOLLYFIELD, J.G., ANDERSON, R.E. & LAVAIL, M.M , pp. 202-210. New York: Plenum Press.
27. NAASH, M.I., HOLLYFIELD, J.G., AL-UBAIDI, M.R. & BAEHR, W (1993b). Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proceedings of the National Academy of Sciences of the U.S.A. 90, 5499-5503.
28. NAASH, M.I., PEACHEY, N.S., Li, Z., GRYCZAN, C.C., GOTO, Y., BLANKS, J., MILAM, A.H. & RIPPS, H. (1996). Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant opsin. Investigative Ophthalmology and Visual Science 37, 775-782.
29. NOELL, W.K., WALKER, V.S., KANG, B.S. & BERMAN. S. (1966). Retinal damage by light in rats. Investigative Ophthalmology and Visual Science 5, 450-473.
30. OLSSON, J.E., GORDON, J.W., PAWLYK, B.S., ROOF, D., HAYES, A., MOLDAY, R.S., MUKAI, S., COWLEY, G.S., BERSON, E.L. & DRYJA, T.P. (1992). Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal retinitis pigmentosa. Neuron 9, 815-830.
31. ORGANISCIAK, D.T. & WINKLER, B.S. (1994). Retinal light damage: Practical and theoretical considerations. Progress in Retina Eye Research 13, 1-29.
32. RAPP, L.M., NAASH, M.I., WIEGAND, R.D., JOEL, C.D., NIELSEN, J.C. & ANDERSON, R.E. (1985). Morphological and biochemical comparisons between retinal regions having differing susceptibility to photorcceptor degeneration. In Retinal Degeneration: Experimental and Clinical Studies, ed. LAVAIL , M.M., HOLLYFIELD, J.G. & ANDERSON, R.E, pp. 421-437. New York: Alan R. Liss, Inc.
33. SANDBERG, M., WEIGEL-DIFRANCO, C., DRYJA, T. & BERSON, E. (1996). Clinical expression correlates with location of rhodopsin mutation in dominant retinitis pigmentosa. Investigative Ophthalmology and Visual Science 36, 1934-1942.
34. SANYAL, S. & HAWKINS, R.K. (1986). Development and degeneration of retina in rds mutant mice: Effects of light on the rate of degeneration in albino and pigmented homozygous and heterozygous mutant and normal mice. Vision Research 26, 1177-1185.
35. SMITH, S.B., COPE, B.K. & McCov, J.R. (1994). Effects of dark-rearing on the retinal degeneration of the C57BL/6-mivit/mivit mouse. Experimental Eye Research 58, 77-84.
36. SMITH, W.C., ADAMUS, G., VAN DER WEL., H., TIMMERS, A., PALCZEWSKI, K., ULSHAFER, R.J., HARHRAVE, P.A. & McDowELL, J.H. (1995). Alligator rhodopsin: Sequence and biochemical properties. Experimental Eye Research 61, 569-578.
37. STONE, E.S., KIMURA, A.E., NICHOLS, B.E., KHADIVI, P., FISHMAN, G.A. & SHEFIELD, V.C. (1991). Regional distribution of retinal degeneration in patients with ihe proline to histidine mutation in codon 23 of the rhodopsin gene. Ophthalmology 98, 1806-1813.
38. STRYER, L. (1988). Molecular basis of visual excitation. Cold Spring Harbor Symposium on Quantitative Biology 53, 283-294.
39. SUNG, C., SCHNEIDER, B.C., AGARWAL., N., PAPERMASTER, D.S. & NATHANS, J. (1991). Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the U.S.A. 88, 8840-8844.
40. TING, T.D., WU, T.-H., OKAJIMA, T.-LL., PEPPERBERG, D.R. & NAASH, M.I. (1995). Analysis of rhodopsin and retinoids in a transgenic mouse model of ADRP. Investigative Ophthalmology and Visual Science (Abstract) 36, S5.
41. WILLIAMS T.P., HOWELL W.L. (1983) Action spectrum of retinal light damage in albino rats. Investigative Ophthalmology and Visual Science 24, 285-287.
42. Wu, T.-H., Li, S., KOGUT, N.S., PEACHEY, N. & NAASH, M.I. (1996). Expression of P23H mutation in transgenic mice as a model for one form of human autosomal dominant retinitis pigmentosa. Investigative Ophthalmology and Visual Science (Abstract) 37, S999.
43. ZHANG, M., QUIAMBAO, A., LAM, T., ZHANG, S. & Tso, M. (1994). The effect of light exposure on photoreceptor degeneration in transgenic mice with SV40T antigen. Investigative Ophthalmology and Visual Science (Abstract) 93, 1517.