Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 5, 1996, Pages 775-782

  Naash, Muna L ^a,f   Peachey, Neal S ^b,c   Li, Zong Yi ^d   Gryczan, Chester C ^a   Goto, Yoshinobu ^b,c   Blanks, Janet ^e   Milam, Ann H ^d   Ripps, Harris ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b HINES VA HOSPITAL   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e DOHENY EYE INSTITUTE   (United States)

^f University of Illinois Chicago   (United States)

Author keywords

apoptosis; dark rearing; electroretinography; retinitis pigmentosa; rhodopsin; transgenic mice

Indexed keywords

MUTANT PROTEIN; RHODOPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEGENERATION; CONTROLLED STUDY; DENSITOMETRY; ELECTRORETINOGRAPHY; LIGHT DARK CYCLE; MOUSE; NONHUMAN; PHOTORECEPTOR; PHOTOSTIMULATION; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL DEATH; DARK ADAPTATION; DNA PRIMERS; ELECTRORETINOGRAPHY; FEMALE; GENE EXPRESSION; LIGHT; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHOTORECEPTORS; POINT MUTATION; POLYMERASE CHAIN REACTION; RETINAL DEGENERATION; RHODOPSIN; SENSORY DEPRIVATION;

EID: 0029972409     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Noell WK, Walker VS, Rang BS, Berman S. Retinal damage by light in rats. Invest Ophthalmol. 1966;5:450-473.
2. Organisciak DT, Winkler BS. Retinal light damage: Practical and theoretical considerations. Prog Ret Eye Res. 1994;13:1-29.
3. Berson EL. Light deprivation and retinitis pigmentosa. Vision Res. 1980;20:1179-1184.
4. Heckenlively JR, Rodriguez JA, Daiger SP. Autosomal dominant sectoral retinitis pigmentosa: Two families with transversion mutation in codon 23 of rhodopsin. Arch Ophthalinol. 1991;109:84-91.
5. Sandberg M, Pawlyk B, Franson W, Dryja T, Berson E. Effect of light on the rate of ERG decline in transgenic mice with the human rhodopsin Pro23His. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1993;34: 1078.
6. Naash MI, Hollyfield JG, Al-Ubaidi MR, Baehr W. Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Nat Acad Sci USA. 1993;90:5499-5503.
7. Dryja TP, McGee TL, Reichel E, et al. A point mutation of the rhodopsin gene in one form of retinitis pigmentosa. Nature. 1990;343:364-366.
8. Sung G, Schneider BG, Agarwal N, Papermaster DS, Nathans J. Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Proc Natl Acad Sci USA. 1991;88:8840-8844.
9. Berson EL. Retinitis pigmentosa. Invest Ophthalmal Vis Sci. 1993;34:1659-1676.
10. Cheng T, Naash MI. Quantitative analysis of mRNA levels of the transgenic and endogenous opsin genes in retinas of transgenic mice. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:S273.
11. Kemp CM, Jacobson SG, Roman AJ, Sung C, Nathans J. Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. Am J Ophthalmol. 1992;113:165-174.
12. Goto Y, Peachey NS, Ripps H, Naash MI. Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene. Invest Ophthalmol Vis Sci. 1995;36:62-71.
13. Naash MI, Al-Ubaidi MR, Hollyfield JG, Baehr W. Simulation of autosomal dominant retinitis pigmentosa in transgenic mice. In: Hollyfield JG, Anderson RE, LaVail MM, eds. Retinal Degeneration. New York; Plenum Press; 1993:202-210.
14. Dowling JE, Ripps H. Visual adaptation in the retina of the skate. J Gen Physiol. 1970;56:491-520.
15. Ripps H, Snapper A. Computer analysis of photochemical changes in the human retina. Comput Biol Med. 1974;4:107-122.
16. Sun Y, Ripps H. Rhodopsin regeneration in the normal and in the detached/replaced retina of the skate. Exp Eye Res. 1992;55:679-689.
17. Ripps H, Brin KP, Weale RA. Rhodopsin and visual threshold in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1978;17:735-745.
18. Kemp CM, Jacobson SG, Faulkner DJ, Walt RW. Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res. 1988;46:185-197.
19. Perlman I, Auerbach E. The relationship between visual sensitivity and rhodopsin density in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1981;20:758-765.
20. Dawson BA, Lough J. Immunocytochemical localization of transient DNA strand breaks in differentiating myotubes using in situ nick-translation. Devel Biol. 1988;127:362-367.
21. Wijsman JH, Jonker RR, Keijzer R, et al. A new method to detect apoptosis in paraffin sections: In situ endlabeling of fragmented DNA. J Histochem Cytochem. 1993;41:7-12.
22. Li ZY, Milam AH. Apoptosis in retinitis pigmentosa. In: Anderson RE, Hollyfield JG, LaVail MM, eds. Retinal Degeneration II. New York: Plenum Press; 1995:1-8.
23. Penn RD, Hagins WA. Signal transmission along retinal rods and the origin of the electroretinographic a-wave. Nature. 1969;223:201-204.
24. Hood DC, Birch DG. A quantitative measure of the electrical activity of human rod photoreceptors using electroretinography. Vis Neurosa. 1990;5:379-387.
25. Breton ME, Schueller AW, Lamb TD, Pugh EN Jr. Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction. Invest Ophthalmol Vis Sci. 1994;35:295-309.
26. Peachey NS, Goto Y, Quiambao AB, Al-Ubaidi MR. Functional consequences of oncogene-induced photoreceptor degeneration in transgenic mice. Vis Neurosa. 1995;12:513-522.
27. Battelle BA, LaVail MM. Rhodopsin content and rod outer segment length in albino rat eyes: Modification by dark adaptation. Exp Eye Res. 1978;26:487-497.
28. Lolley RN, Rong H, Craft CM. Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction. Invest Ophthalmol Vis Sci. 1994;35:358-362.
29. Ripps H. Night blindness revisited: From man to molecules. Invest Ophthalmol Vis Sci. 1982;23:588-609.
30. LaVail MM. Rod outer segment disk shedding in rat retina: Relationship to cyclic lighting. Science. 1976;194:1071-1074.
31. Chang GQ, Hao Y, Wong F. Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron. 1993;11:595-605.
32. Portera-Cailliau C, Sung CH, Nathans J, Adler R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA. 1994;91:974-978.
33. Berson EL, Rosner B, Sandberg MA, Dryja TP. Ocular findings in patients with autosomal dominant retinitis pigmentosa and a rhodopsin gene defect (Pro-23-His). Arch Ophthalmol. 1991;109:92-101.
34. Stone ES, Kimura AE, Nichols BE, et al. Regional distribution of retinal degeneration in patients with the proline to histidine mutation in codon 23 of the rhodopsin gene. Ophthalmology. 1991;98:1806-1813.
35. Berson EL. Light deprivation for early retinitis pigmentosa: A hypothesis. Arch Ophthalmol. 1971;85:521-529.
36. Olsson JE, Gordon JW, Pawlyk BS, et al. Transgenic mice with a rhodopsin mutation (Pro23His) : A mouse model of autosomal retinitis pigmentosa. Neuron. 1992;9:815-830.
37. Bowling J, Sidman R. Inherited retinal dystrophy in rats. J Cell Biol. 1962;14:73-109.
38. LaVail MM, Battelle BA. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res. 1975;21:167-192.
39. Sanyal S, Hawkins RK. Development and degeneration of retina in rds mutant mice: Effects of light on the rate of degeneration in albino and pigmented homozygous and heterozygous mutant and normal mice. Vision Res. 1986;26:1177-1185.
40. LaVail MM, White MP, Gorrin GM, Yasumura D, Porrello KV, Mullen RJ. Retinal degeneration in the nervous mutant mouse: I: Light microscopic cytopathology and changes in the interphotoreceptor matrix. J Comp Neural. 1993;333:168-181.
41. vit mouse. Exp Eye Res. 1994;58:77-84.
42. Gryczan C, Kuszak JR, Novak L, Peachey NS, Goto Y, Naash MI. A transgenic mouse model for autosomal dominant retinitis pigmentosa caused by a three base pair deletion in codon 255/256 of the opsin gene. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36: S423.
43. Li T, Franson WK, Gordon JW, Berson EL, Dryja TP. Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration. Proc Natl Acad Sci USA. 1995;92:3551-3555.
44. Wang M, Lam TT, Tso MOM, Naash MI. Expression of mutant opsin gene in transgenic mice increases susceptibility of the retina to light damage. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:1078.