IL-13 Receptor α2 Promotes Epithelial Cell Regeneration From Radiation-Induced Small Intestinal Injury in Mice

Gastroenterology

Volumn 131, Issue 1, 2006, Pages 130-141

  Kawashima, Rei ^a   Kawamura, Yuki I ^a,b   Kato, Rie ^a   Mizutani, Noriko ^a   Toyama Sorimachi, Noriko ^a   Dohi, Taeko ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b GS PlatZ Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; HUMAN IMMUNOGLOBULIN; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 4; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DAMAGE; CELL DIVISION; CELL REGENERATION; EPITHELIUM CELL; FEMALE; FIBROBLAST; GASTROINTESTINAL TRACT; INJURY SEVERITY; INTESTINE INJURY; INTESTINE MUCOSA; JEJUNUM; KNOCKOUT GENE; KNOCKOUT MOUSE; LAMINA PROPRIA; MOUSE; MYOFIBROBLAST; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION INJURY; RECEPTOR UPREGULATION; SMALL INTESTINE; TISSUE REPAIR; UPREGULATION; WHOLE BODY RADIATION; WILD TYPE; X IRRADIATION;

EID: 33745743021     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.04.022     Document Type: Article

References (35)

1. Urban Jr. J., Noben-Trauth N., Donaldson D., Madden K., Morris S., Collins M., and Finkelman F. IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8 (1998) 255-264
2. Finkelman F.D., Shea-Donohue T., Morris S.C., Gildea L., Strait R., Madden K.B., Schopf L., and Urban Jr. J.F. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev 201 (2004) 139-155
3. Shea-Donohue T., Sullivan C., Finkelman F.D., Madden K.B., Morris S.C., Goldhill J., Pineiro-Carrero V., and Urban Jr. J.F. The role of IL-4 in Heligmosomoides polygyrus-induced alterations in murine intestinal epithelial cell function. J Immunol 167 (2001) 2234-2239
4. Dohi T., Fujihashi K., Rennert P.D., Iwatani K., Kiyono H., and McGhee J.R. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper 2-type responses. J Exp Med 189 (1999) 1169-1180
5. Dohi T., Fujihashi K., Kiyono H., Elson C.O., and McGhee J.R. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119 (2000) 724-733
6. Dohi T., Rennert P.D., Fujihashi K., Kiyono H., Shirai Y., Kawamura Y.I., Browning J.L., and McGhee J.R. Lymphotoxin-β receptor-immunoglobulin fusion protein inhibits murine colonic patch genesis and Th2-type colitis. J Immunol 167 (2001) 2781-2790
7. Boirivant M., Fuss I.J., Chu A., and Strober W. Oxazolone colitis. a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188 (1998) 1929-1939
8. Heller F., Fuss I.J., Nieuwenhuis E.E., Blumberg R.S., and Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17 (2002) 629-638
9. Dohi T., Fujihashi K., Koga T., Shirai Y., Kawamura Y.I., Ejima C., Kato R., Saitoh K., and McGhee J.R. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia and wasting disease in T cell-deficient mice. Gastroenterology 124 (2003) 672-682
10. +CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165 (2004) 1257-1268
11. Zurawski S.M., Vega Jr. F., Huyghe B., and Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 12 (1993) 2663-2670
12. Chiaramonte M., Mentink-Kane M., Jacobson B., Cheever A., Whitters M., Goad M., Wong A., Collins M., Donaldson D., Grusby M., and Wynn T. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197 (2003) 687-701
13. Wood N., Whitters M., Jacobson B., Witek J., Sypek J., Kasaian M., Eppihimer M., Unger M., Tanaka T., Goldman S., Collins M., Donaldson D., and Grusby M. Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor. J Exp Med 197 (2003) 703-709
14. Zhang J.G., Hilton D.J., Willson T.A., McFarlane C., Roberts B.A., Moritz R.L., Simpson R.J., Alexander W.S., Metcalf D., and Nicola N.A. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned IL-13 receptor and IL-4 receptor alpha-chains. J Biol Chem 272 (1997) 9474-9480
15. Donaldson D., Whitters M., Fitz L., Neben T., Finnerty H., Henderson S., O'Hara R., Beier D., Turner K., Wood C., and Collins M. The murine IL-13 receptor alpha 2. molecular cloning, characterization. J Immunol 161 (1998) 2317-2324
16. Blease K., Schuh J.M., Jakubzick C., Lukacs N.W., Kunkel S.L., Joshi B.H., Puri R.K., Kaplan M.H., and Hogaboam C.M. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 160 (2002) 481-490
17. Webb D., Mahalingam S., Cai Y., Matthaei K., Donaldson D., and Foster P. Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity. Eur J Immunol 33 (2003) 3377-3385
18. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A 94 (1997) 10838-10843
19. Withers H.R., and Elkind M.M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med 17 (1970) 261-267
20. Hirata T., Merrill-Skoloff G., Aab M., Yang J., Furie B.C., and Furie B. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J Exp Med 192 (2000) 1669-1676
21. Nosaka T., Kawashima T., Misawa K., Ikuta K., Mui A.L., and Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 18 (1999) 4754-4765
22. Mashimo H., Wu D.C., Podolsky D.K., and Fishman M.C. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 274 (1996) 262-265
23. Beck P.L., Wong J.F., Li Y., Swaminathan S., Xavier R.J., Devaney K.L., and Podolsky D.K. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology 126 (2004) 796-808
24. Potten C.S. Stem cells in gastrointestinal epithelium. numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci 353 (1998) 821-830
25. Blais Y., Gingras S., Haagensen D.E., Labrie F., and Simard J. Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells. Mol Cell Endocrinol 121 (1996) 11-18
26. Serve H., Oelmann E., Herweg A., Oberberg D., Serve S., Reufi B., Mucke C., Minty A., Thiel E., and Berdel W.E. Inhibition of proliferation and clonal growth of human breast cancer cells by interleukin 13. Cancer Res 56 (1996) 3583-3588
27. Renard N., Duvert V., Banchereau J., and Saeland S. Interleukin-13 inhibits the proliferation of normal and leukemic human. Blood 84 (1994) 2253-2260
28. Mattes J., Yang M., Siqueira A., Clark K., MacKenzie J., McKenzie A.N., Webb D.C., Matthaei K.I., and Foster P.S. IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J Immunol 167 (2001) 1683-1692
29. Zund G., Madara J.L., Dzus A.L., Awtrey C.S., and Colgan S.P. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion. J Biol Chem 271 (1996) 7460-7464
30. Harrington N.P., Chambers K.A., Ross W.M., and Filion L.G. Radiation damage and immune suppression in splenic mononuclear cell populations. Clin Exp Immunol 107 (1997) 417-424
31. Louagie H., Van Eijkeren M., Philippe J., Thierens H., and de Ridder L. Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy. Int J Radiat Biol 75 (1999) 767-771
32. Peritt D., Robertson S., Gri G., Showe L., Aste-Amezaga M., and Trinchieri G. Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol 161 (1998) 5821-5824
33. Hoshino T., Winkler-Pickett R.T., Mason A.T., Ortaldo J.R., and Young H.A. IL-13 production by NK cells. IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ. J Immunol 162 (1999) 51-59
34. Housley R.M., Morris C.F., Boyle W., Ring B., Biltz R., Tarpley J.E., Aukerman S.L., Devine P.L., Whitehead R.H., and Pierce G.F. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J Clin Invest 94 (1994) 1764-1777
35. Bajaj-Elliott M., Poulsom R., Pender S.L., Wathen N.C., and MacDonald T.T. Interactions between stromal cell-derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. J Clin Invest 102 (1998) 1473-1480