메뉴 건너뛰기




Volumn 54, Issue 4, 2006, Pages 321-326

Nongenomic actions of estrogens: Exciting opportunities for pharmacology

Author keywords

Estrogen; Nongenomic actions; Rapid responses; Steroid

Indexed keywords

ACOLBIFENE; ANTIESTROGEN; DAIDZEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ETHINYLESTRADIOL; FULVESTRANT; GENISTEIN; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

EID: 33745699901     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2006.04.021     Document Type: Article
Times cited : (9)

References (38)
  • 1
    • 0037662032 scopus 로고    scopus 로고
    • Nongenomic steroid action: controversies, questions, and answers
    • Lösel R.M., Falkenstein E., Feuring M., et al. Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 83 (2003) 965-1016
    • (2003) Physiol Rev , vol.83 , pp. 965-1016
    • Lösel, R.M.1    Falkenstein, E.2    Feuring, M.3
  • 2
    • 0014140501 scopus 로고
    • Adenosine 3′,5′-monophosphate in rat uterus: acute elevation by estrogen
    • Szego C.M., and Davis J.S. Adenosine 3′,5′-monophosphate in rat uterus: acute elevation by estrogen. Proc Natl Acad Sci USA 58 (1967) 1711-1718
    • (1967) Proc Natl Acad Sci USA , vol.58 , pp. 1711-1718
    • Szego, C.M.1    Davis, J.S.2
  • 3
    • 0017354142 scopus 로고
    • Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells
    • Pietras R.J., and Szego C.M. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells. Nature 265 (1977) 69-72
    • (1977) Nature , vol.265 , pp. 69-72
    • Pietras, R.J.1    Szego, C.M.2
  • 6
    • 0028154102 scopus 로고
    • Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women
    • Reis S.E., Gloth S.T., Blumenthal R.S., et al. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 89 (1994) 52-60
    • (1994) Circulation , vol.89 , pp. 52-60
    • Reis, S.E.1    Gloth, S.T.2    Blumenthal, R.S.3
  • 7
    • 0035895323 scopus 로고    scopus 로고
    • The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol
    • Walker H.A., Dean T.S., Sanders T.A., Jackson G., Ritter J.M., and Chowienczyk P.J. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol. Circulation 103 (2001) 258-262
    • (2001) Circulation , vol.103 , pp. 258-262
    • Walker, H.A.1    Dean, T.S.2    Sanders, T.A.3    Jackson, G.4    Ritter, J.M.5    Chowienczyk, P.J.6
  • 8
    • 0032589745 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
    • Chen Z., Yuhanna I.S., Galcheva-Gargova Z., Karas R.H., Mendelsohn M.E., and Shaul P.W. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest 103 (1999) 401-406
    • (1999) J Clin Invest , vol.103 , pp. 401-406
    • Chen, Z.1    Yuhanna, I.S.2    Galcheva-Gargova, Z.3    Karas, R.H.4    Mendelsohn, M.E.5    Shaul, P.W.6
  • 9
    • 0034644608 scopus 로고    scopus 로고
    • Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells
    • Haynes M.P., Sinha D., Russell K.S., et al. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res 87 (2000) 677-682
    • (2000) Circ Res , vol.87 , pp. 677-682
    • Haynes, M.P.1    Sinha, D.2    Russell, K.S.3
  • 10
    • 0034711337 scopus 로고    scopus 로고
    • ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?
    • Mendelsohn M.E., and Nongenomic. ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?. Circ Res 87 (2000) 956-960
    • (2000) Circ Res , vol.87 , pp. 956-960
    • Mendelsohn, M.E.1    Nongenomic2
  • 11
    • 1842638505 scopus 로고    scopus 로고
    • Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways
    • Bulayeva N.N., Gametchu B., and Watson C.S. Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways. Steroids 69 (2004) 181-192
    • (2004) Steroids , vol.69 , pp. 181-192
    • Bulayeva, N.N.1    Gametchu, B.2    Watson, C.S.3
  • 12
    • 1342288028 scopus 로고    scopus 로고
    • An ICI 182, 780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity
    • Marin R., Guerra B., Morales A., Diaz M., and Alonso R. An ICI 182, 780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity. Ann NY Acad Sci 1007 (2003) 108-116
    • (2003) Ann NY Acad Sci , vol.1007 , pp. 108-116
    • Marin, R.1    Guerra, B.2    Morales, A.3    Diaz, M.4    Alonso, R.5
  • 13
    • 0035834075 scopus 로고    scopus 로고
    • Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line
    • Vasudevan N., Kow L.M., and Pfaff D.W. Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line. Proc Natl Acad Sci USA 98 (2001) 12267-12271
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12267-12271
    • Vasudevan, N.1    Kow, L.M.2    Pfaff, D.W.3
  • 14
    • 0033732896 scopus 로고    scopus 로고
    • Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer
    • Razandi M., Pedram A., and Levin E.R. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol 14 (2000) 1434-1447
    • (2000) Mol Endocrinol , vol.14 , pp. 1434-1447
    • Razandi, M.1    Pedram, A.2    Levin, E.R.3
  • 15
    • 3042843668 scopus 로고    scopus 로고
    • Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt
    • Fernando R.I., and Wimalasena J. Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt. Mol Biol Cell 15 (2004) 3266-3284
    • (2004) Mol Biol Cell , vol.15 , pp. 3266-3284
    • Fernando, R.I.1    Wimalasena, J.2
  • 16
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo E.J., Quinn J.A., Bland K.I., and Frackelton Jr. A.R. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol 14 (2000) 1649-1660
    • (2000) Mol Endocrinol , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton Jr., A.R.4
  • 17
    • 18144381249 scopus 로고    scopus 로고
    • Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells
    • Pietras R.J., Marquez D.C., Chen H.W., Tsai E., Weinberg O., and Fishbein M. Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells. Steroids 70 (2005) 372-381
    • (2005) Steroids , vol.70 , pp. 372-381
    • Pietras, R.J.1    Marquez, D.C.2    Chen, H.W.3    Tsai, E.4    Weinberg, O.5    Fishbein, M.6
  • 18
    • 0037133569 scopus 로고    scopus 로고
    • Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene
    • Simoncini T., Genazzani A.R., and Liao J.K. Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation 105 (2002) 1368-1373
    • (2002) Circulation , vol.105 , pp. 1368-1373
    • Simoncini, T.1    Genazzani, A.R.2    Liao, J.K.3
  • 19
    • 0141619266 scopus 로고    scopus 로고
    • Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells
    • Mori-Abe A., Tsutsumi S., Takahashi K., et al. Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol 178 (2003) 417-426
    • (2003) J Endocrinol , vol.178 , pp. 417-426
    • Mori-Abe, A.1    Tsutsumi, S.2    Takahashi, K.3
  • 20
    • 0036096224 scopus 로고    scopus 로고
    • Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator
    • Simoncini T., Varone G., Fornari L., et al. Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator. Endocrinology 143 (2002) 2052-2061
    • (2002) Endocrinology , vol.143 , pp. 2052-2061
    • Simoncini, T.1    Varone, G.2    Fornari, L.3
  • 21
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    • Kousteni S., Bellido T., Plotkin L.I., et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104 (2001) 719-730
    • (2001) Cell , vol.104 , pp. 719-730
    • Kousteni, S.1    Bellido, T.2    Plotkin, L.I.3
  • 22
    • 0037174675 scopus 로고    scopus 로고
    • Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    • Kousteni S., Chen J.R., Bellido T., et al. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298 (2002) 843-846
    • (2002) Science , vol.298 , pp. 843-846
    • Kousteni, S.1    Chen, J.R.2    Bellido, T.3
  • 23
    • 0034711335 scopus 로고    scopus 로고
    • Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
    • Chambliss K.L., Yuhanna I.S., Mineo C., et al. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res 87 (2000) E44-E52
    • (2000) Circ Res , vol.87
    • Chambliss, K.L.1    Yuhanna, I.S.2    Mineo, C.3
  • 24
    • 3042645224 scopus 로고    scopus 로고
    • Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain
    • Abraham I.M., Todman M.G., Korach K.S., and Herbison A.E. Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology 145 (2004) 3055-3061
    • (2004) Endocrinology , vol.145 , pp. 3055-3061
    • Abraham, I.M.1    Todman, M.G.2    Korach, K.S.3    Herbison, A.E.4
  • 25
    • 0037069418 scopus 로고    scopus 로고
    • Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
    • Wong C.W., McNally C., Nickbarg E., Komm B.S., and Cheskis B.J. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci USA 99 (2002) 14783-14788
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14783-14788
    • Wong, C.W.1    McNally, C.2    Nickbarg, E.3    Komm, B.S.4    Cheskis, B.J.5
  • 27
    • 85047675402 scopus 로고    scopus 로고
    • Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors
    • Gu Q., Korach K.S., and Moss R.L. Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors. Endocrinology 140 (1999) 660-666
    • (1999) Endocrinology , vol.140 , pp. 660-666
    • Gu, Q.1    Korach, K.S.2    Moss, R.L.3
  • 28
    • 0036813660 scopus 로고    scopus 로고
    • ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury
    • Toran-Allerand C.D., Guan X., MacLusky N.J., et al. ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci 22 (2002) 8391-8401
    • (2002) J Neurosci , vol.22 , pp. 8391-8401
    • Toran-Allerand, C.D.1    Guan, X.2    MacLusky, N.J.3
  • 29
    • 0036140032 scopus 로고    scopus 로고
    • Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    • Filardo E.J., Quinn J.A., Frackelton Jr. A.R., and Bland K.I. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol 16 (2002) 70-84
    • (2002) Mol Endocrinol , vol.16 , pp. 70-84
    • Filardo, E.J.1    Quinn, J.A.2    Frackelton Jr., A.R.3    Bland, K.I.4
  • 30
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • Thomas P., Pang Y., Filardo E.J., and Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 (2005) 624-632
    • (2005) Endocrinology , vol.146 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 31
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., and Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307 (2005) 1625-1630
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 32
    • 26444467147 scopus 로고    scopus 로고
    • Estrogen receptors and cell signaling
    • Pietras R.J., Levin E.R., and Szego C.M. Estrogen receptors and cell signaling. Science 310 (2005) 51-53
    • (2005) Science , vol.310 , pp. 51-53
    • Pietras, R.J.1    Levin, E.R.2    Szego, C.M.3
  • 33
    • 0034633656 scopus 로고    scopus 로고
    • Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta
    • Nadal A., Ropero A.B., Laribi O., Maillet M., Fuentes E., and Soria B. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. Proc Natl Acad Sci USA 97 (2000) 11603-11608
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11603-11608
    • Nadal, A.1    Ropero, A.B.2    Laribi, O.3    Maillet, M.4    Fuentes, E.5    Soria, B.6
  • 34
    • 0030866902 scopus 로고    scopus 로고
    • A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction
    • Li J., and Chory J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90 (1997) 929-938
    • (1997) Cell , vol.90 , pp. 929-938
    • Li, J.1    Chory, J.2
  • 35
    • 18244413938 scopus 로고    scopus 로고
    • Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report
    • Norman A.W., Bishop J.E., Collins E.D., et al. Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report. J Steroid Biochem Mol Biol 56 (1996) 13-22
    • (1996) J Steroid Biochem Mol Biol , vol.56 , pp. 13-22
    • Norman, A.W.1    Bishop, J.E.2    Collins, E.D.3
  • 37
    • 0345874610 scopus 로고    scopus 로고
    • Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    • Norman A.W., Mizwicki M.T., and Norman D.P. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 3 (2004) 27-41
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 27-41
    • Norman, A.W.1    Mizwicki, M.T.2    Norman, D.P.3
  • 38
    • 0042093742 scopus 로고    scopus 로고
    • Estrogen plus progestin and the risk of coronary heart disease
    • Manson J.E., Hsia J., Johnson K.C., et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
    • (2003) N Engl J Med , vol.349 , pp. 523-534
    • Manson, J.E.1    Hsia, J.2    Johnson, K.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.