Nongenomic, estrogen receptor-mediated activation of endothelial nitric oxide synthase: How does it work? What does it mean?

Circulation Research

Volumn 87, Issue 11, 2000, Pages 956-960

  Mendelsohn, Michael E ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Caveolae; Endothelium; Estrogen; Nitric oxide; Receptor

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; NITRIC OXIDE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; NOS3 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT;

ANGINA PECTORIS; ATHEROSCLEROSIS; CORONARY ARTERY THROMBOSIS; DISEASE COURSE; ENZYME ACTIVATION; ESTROGEN THERAPY; HORMONE RECEPTOR INTERACTION; HUMAN; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; VASCULAR ENDOTHELIUM; ANIMAL; CARDIOVASCULAR DISEASE; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYMOLOGY; FEMALE; HORMONE SUBSTITUTION; METABOLISM; NOTE; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARDIOVASCULAR DISEASES; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ESTROGENS; FEMALE; HORMONE REPLACEMENT THERAPY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION;

EID: 0034711337     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.11.956     Document Type: Review

References (38)

1. Hormone therapy to prevent disease and prolong life in postmenopausal women
2. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
3. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis
4. Coronary heart disease in women: An ounce of prevention
5. The protective effects of estrogen on the cardiovascular system
6. Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium
7. 2+ mobilization
8. Estrogen receptor a mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
9. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the P13-kinase-Akt pathway in human endothelial cells
10. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
11. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
12. Differential effects of estradiol and estradiol-BSA conjugates
13. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells
14. Signaling themes shared between peptide and steroid hormones at the plasma membrane
15. Membrane-initiated steroid actions and the proteins that mediate them
16. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
17. Dynamic activation of endothelial nitric oxide synthase by Hsp90
18. Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
19. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae
20. Role of plasmalemmal caveolae in signal transduction
21. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
22. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
23. Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia
24. Estrogen signals to the preservation of endothelial cell form and function
25. Tyrosine kinase/p21(ras)/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
26. Rapid activation of MAP kinase by estrogen in the bone cell line
27. Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells: Effects on calcium sensitivity and NO release
28. Cellular functions of the plasma membrane estrogen receptor
29. Signaling through scaffold, anchoring, and adaptor proteins
30. 5 and γ-aminobutyric acid A receptors
31. Identification of a new isoform of the human estrogen receptor α (hERα) that is encoded by distinct transcripts and that is able to repress hERα activation function 1
32. Human vascular smooth muscle cells contain functional estrogen receptor
33. Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells
34. Effects of 17β-estradiol on cytokine-induced endothelial cell adhesion molecular expression
35. Identification of authentic estrogen receptor in cultured endothelial cells: A potential mechanism for steroid hormone regulation of endothelial function
36. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo