Knock-down of GFRα4 expression by RNA interference affects the development of retinal cell types in three-dimensional histiotypic retinal spheres

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 6, 2006, Pages 2716-2725

  Rothermel, Andrée ^a   Volpert, Katja ^b   Burghardt, Mirjam ^b   Lantzsch, Christina ^a   Robitzki, Andrea A ^a   Layer, Paul G ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR FAMILY RECEPTOR ALPHA 4; MESSENGER RNA; OPSIN; RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PAX6; AVIAN PROTEIN; EYE PROTEIN; GFR RECEPTOR ALPHA 4, GALLUS GALLUS; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; HOMEODOMAIN PROTEIN; MEMBRANE PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SIZE; CELL TYPE; CHICKEN; CONTROLLED STUDY; EMBRYO; GANGLION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; RETINA; RETINA AMACRINE CELL; RETINA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; ANIMAL; CELL COUNT; CHICK EMBRYO; CYTOLOGY; EMBRYO DEVELOPMENT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL; RETINA HORIZONTAL NERVE CELL; RNA PROBE;

AMACRINE CELLS; ANIMALS; APOPTOSIS; AVIAN PROTEINS; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHICK EMBRYO; EMBRYONIC DEVELOPMENT; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE SILENCING; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MEMBRANE GLYCOPROTEINS; OPSIN; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; RETINA; RETINAL BIPOLAR CELLS; RETINAL GANGLION CELLS; RETINAL HORIZONTAL CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PROBES; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 33745652761     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-1472     Document Type: Article

References (45)

1. Airaksinen MS, Titievsky A, Saarma M. GDNF family neurotrophic factor signaling: four masters, one servant? Mol Cell Neurosci. 1999;13:313-325.
2. Enomoto H. Regulation of neural development by glial cell line-derived neurotrophic factor family ligands. Anat Sci Int. 2005;80:42-52.
3. Homma S, Oppenheim RW, Yaginuma H, Kimura S. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Dev Biol. 2000;217:121-137.
4. Baloh RH, Enomoto H, Johnson EM Jr, Milbrandt J. The GDNF family ligands and receptors - implications for neural development. Curr Opin Neurobiol. 2000;10:103-110.
5. Takahashi M. The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev. 2001;12:361-373.
6. Karlsson M, Lindqvist N, Mayordomo R, Hallbook F. Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina. Mech Dev. 2002;114:161-165.
7. Jomary C, Thomas M, Grist J, Milbrandt J, Neal MJ, Jones SE. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest Ophthalmol Vis Sci. 1999;40:568-574.
8. Jomary C, Darrow RM, Wong P, Organisciak DT, Jones SE. Expression of neurturin, glial cell line-derived neurotrophic factor, and their receptor components in light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2004;45:1240-1246.
9. Lindqvist N, Peinado-Ramonn P, Vidal-Sanz M, Hallbook F. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Exp Neurol. 2004;187:487-499.
10. Politi LE, Rotstein NP, Carri NG. Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid. Invest Ophthalmol Vis Sci. 2001;42:3008-3015.
11. Rothermel A, Layer PG. GDNF regulates chicken rod photoreceptor development and survival in reaggregated histiotypic retinal spheres. Invest Ophthalmol Vis Sci. 2003;44:2221-2228.
12. Rothermel A, Volpert K, Schlichting R, et al. Spatial and temporal expression patterns of GDNF family receptor alpha4 in the developing chicken retina. Gene Expr Patterns. 2004;4:59-63.
13. Robitzki A, Mack A, Chatonnet A, Layer PG. Transfection of reaggregating embryonic chicken retinal cells with an antisense 5′-DNA butyrylcholinesterase expression vector inhibits proliferation and alters morphogenesis. J Neurochem. 1997;69:823-833.
14. Robitzki A, Mack A, Hoppe U, Chatonnet A, Layer PG. Butyrylcholinesterase antisense transfection increases apoptosis in differentiating retinal reaggregates of the chick embryo. J Neurochem. 1998;71:413-420.
15. Robitzki A, Doll F, Richter-Landsberg C, Layer PG. Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase. Glia. 2000;31:195-205.
16. Mack A, Robitzki A. The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5′butyrylcholinesterase- DNA study. Prog Neurobiol. 2000;60:607-628.
17. Layer PG, Willbold E. Histogenesis of the avian retina in reaggregation culture: from dissociated cells to laminar neuronal networks. Int Rev Cytol. 1993;146:1-47.
18. Layer PG, Robitzki A, Rothermel A, Willbold E. Of layers and spheres: the reaggregate approach in tissue engineering. Trends Neurosci. 2002;25:131-134.
19. Rothermel A, Willbold E, Degrip WJ, Layer PG. Pigmented epithelium induces complete retinal reconstitution from dispersed embryonic chick retinae in reaggregation culture. Proc Biol Sci. 1997;264:1293-1302.
20. Willbold E, Layer PG. Muller glia cells and their possible roles during retina differentiation in vivo and in vitro. Histol Histopathol. 1998;13:531-552.
21. Fischer AJ, Reh TA. Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina. Dev Biol. 2002;251:367-379.
22. Xie HQ, Adler R. Green cone opsin and rhodopsin regulation by CNTF and staurosporine in cultured chick photoreceptors. Invest Ophthalmol Vis Sci. 2000;41:4317-4323.
23. Hannon GJ, Rossi JJ. Unlocking the potential of the human genome with RNA interference. Nature. 2004;431:371-378.
24. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-22 nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411:494-498.
25. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296:550-553.
26. Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 2002;30:1757-1766.
27. James J, Das AV, Bhattacharya S, Chacko DM, Zhao X, Ahmad I. In vitro generation of early-born neurons from late retinal progenitors. J Neurosci. 2003;23:8193-8203.
28. Hatakeyama J, Kageyama R. Retinal cell fate determination and bHLH factors. Semin Cell Dev Biol. 2004;15:83-89.
29. Klein RD, Sherman D, Ho WH, et al. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature. 1997;387:717-721.
30. Milbrandt J, de Sauvage FJ, Fahrner TJ, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron. 1998;20:245-253.
31. Oppenheim RW, Houenou LJ, Parsadanian AS, Prevette D, Snider WD, Shen L. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes. J Neurosci. 2000;20:5001-5011.
32. Cepko CL. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurobiol. 1999;9:37-46.
33. Livesey FJ, Cepko CL. Vertebrate neural cell-fate determination: lessons from the retina. Nat Rev Neurosci. 2001;2:109-118.
34. Vetter ML, Brown NL. The role of basic helix-loop-helix genes in vertebrate retinogenesis. Semin Cell Dev Biol. 2001;12:491-498.
35. Ishibashi M, Ang SL, Shiota K, Nakanishi S, Kageyama R, Guillemot F. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995;15:3136-3148.
36. Dyer MA, Livesey FJ, Cepko CL, Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet. 2003;34:53-58.
37. Milam AH, Rose L, Cideciyan AV, et al. The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration. Proc Natl Acad Sci USA. 2002;99:473-478.
38. Nishiguchi KM, Friedman JS, Sandberg MA, Swaroop A, Berson EL, Dryja TP. Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function. Proc Natl Acad Sci USA. 2004;101:17819-17824.
39. Mears AJ, Kondo M, Swain PK, et al. Nrl is required for rod photoreceptor development. Nat Genet. 2001;29:447-452.
40. Graham DR, Overbeek PA, Ash JD. Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation. Invest Ophthalmol Vis Sci. 2005;46:2601-2610.
41. Corbo JC, Cepko CL. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005;1:140-153.
42. Szel A, van Veen T, Rohlich P. Retinal cone differentiation. Nature. 1994;370:336.
43. Wikler KC, Szel A, Jacobsen AL. Positional information and opsin identity in retinal cones. J Comp Neurol. 1996;374:96-107.
44. Szel A, Juliusson B, Bergstrom A, Wilke K, Ehinger B, van Veen T. Reversed ratio of color-specific cones in rabbit retinal cell transplants. Brain Res Dev Brain Res. 1994;81:1-9.
45. Cepko C. Giving in to the blues. Nat Genet. 2000;24:99 -100.