Microstimulation of macaque area LIP affects decision-making in a motion discrimination task

Nature Neuroscience

Volumn 9, Issue 5, 2006, Pages 682-689

  Hanks, Timothy D ^a   Ditterich, Jochen ^a,b   Shadlen, Michael N ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; CLUSTER ANALYSIS; COGNITION; CONTROLLED STUDY; DECISION MAKING; DISCRIMINATION LEARNING; ELECTROSTIMULATION; MACACA; MEMORY; MOTION; NERVE CELL; NEUROSCIENCE; NONHUMAN; PARIETAL LOBE; PHYSIOLOGY; PRIORITY JOURNAL; REACTION TIME; SACCADIC EYE MOVEMENT; TASK PERFORMANCE;

ACTION POTENTIALS; ANIMALS; BEHAVIOR, ANIMAL; DECISION MAKING; DISCRIMINATION (PSYCHOLOGY); ELECTRIC STIMULATION; MACACA MULATTA; MOTION PERCEPTION; NEURONS; PARIETAL LOBE; PHOTIC STIMULATION; REACTION TIME; SACCADES;

EID: 33745625592     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1683     Document Type: Article

References (50)

1. de Lafuente, V. & Romo, R. Neuronal correlates of subjective sensory experience. Nat. Neurosci. 8, 1698-1703 (2005).
2. Schall, J. & Thompson, K. Neural selection and control of visually guided eye movements. Annu. Rev. Neurosci. 22, 241-259 (1999).
3. Glimcher, P.W. The neurobiology of visual-saccadic decision making. Annu. Rev. Neurosci. 26, 133-179 (2003).
4. Romo, R. & Salinas, E. Flutter discrimination: neural codes, perception, memory and decision making. Nat. Rev. Neurosci. 4, 203-218 (2003).
5. Pasternak, T. & Merigan, W.H. Motion perception following lesions of the superior temporal sulcus in the monkey. Cereb. Cortex 4, 247-259 (1994).
6. Britten, K.H., Shadlen, M.N., Newsome, W.T. & Movshon, J.A. The analysis of visual motion: a comparison of neuronal and psychophysical performance. J. Neurosci. 12, 4745-4765 (1992).
7. Salzman, C.D., Murasugi, C.M., Britten, K.H. & Newsome, W.T. Microstimulation in visual area MT: effects on direction discrimination performance. J. Neurosci. 12, 2331-2355 (1992).
8. Newsome, W.T. & Paré, E.B. A selective impairment of motion perception following lesions of the middle temporal visual area (MT). J. Neurosci. 8, 2201-2211 (1988).
9. Gold, J.I. & Shadlen, M.N. The influence of behavioral context on the representation of a perceptual decision in developing oculomotor commands. J. Neurosci. 23, 632-651 (2003).
10. Roitman, J.D. & Shadlen, M.N. Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task. J. Neurosci. 22, 9475-9489 (2002).
11. Shadlen, M.N. & Newsome, W.T. Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey. J. Neurophysiol. 86, 1916-1936 (2001).
12. Colby, C.L. & Goldberg, M.E. Space and attention in parietal cortex. Annu. Rev. Neurosci. 22, 319-349 (1999).
13. Andersen, R.A. & Buneo, C.A. Intentional maps in posterior parietal cortex. Annu. Rev. Neurosci. 25, 189-220 (2002).
14. Born, R.T. & Bradley, D.C. Structure and function of visual area MT. Annu. Rev. Neurosci. 28, 157-189 (2005).
15. Britten, K.H., Shadlen, M.N., Newsome, W.T. & Movshon, J.A. Responses of neurons in macaque MT to stochastic motion signals. Vis. Neurosci. 10, 1157-1169 (1993).
16. Ditterich, J., Mazurek, M. & Shadlen, M.N. Microstimulation of visual cortex affects the speed of perceptual decisions. Nat. Neurosci. 6, 891-898 (2003).
17. Ratcliff, R. & Rouder, J.N. Modeling response times for two-choice decisions. Psychol. Sci. 9, 347-356 (1998).
18. Mazurek, M.E., Roitman, J.D., Ditterich, J. & Shadlen, M.N. A role for neural integrators in perceptual decision making. Cereb. Cortex 13, 1257-1269 (2003).
19. Holmes, P. et al. Optimal decisions: from neural spikes, through stochastic differential equations, to behavior. IEICE Transactions on Fundamentals of Electronics, Communications and Computer Science 88, 2496-2503 (2005).
20. Ratcliff, R. & Smith, P. A comparison of sequential sampling models for two-choice reaction time. Psychol. Rev. 111, 333-367 (2004).
21. Link, S.W. The Wave Theory of Difference and Similarity (Lawrence Erlbaum Associates, Hillsdale, New Jersey, 1992).
22. Palmer, J., Huk, A.C. & Shadlen, M.N. The effect of stimulus strength on the speed and accuracy of a perceptual decision. J. Vis. 5, 376-404 (2005).
23. Bisley, J.W., Zaksas, D. & Pasternak, T. Microstimulation of cortical area MT affects performance on a visual working memory task. J. Neurophysiol. 85, 187-196 (2001).
24. Gottlieb, J. & Goldberg, M.E. Activity of neurons in the lateral intraparietal area of the monkey during an antisaccade task. Nat. Neurosci. 2, 906-912 (1999).
25. Wardak, C., Olivier, E. & Duhamel, J.R. A deficit in covert attention after parietal cortex inactivation in the monkey. Neuron 42, 501-508 (2004).
26. Bisley, J.W. & Goldberg, M.E. Neuronal activity in the lateral intraparietal area and spatial attention. Science 299, 81-86 (2003).
27. Gottlieb, J.P., Kusunoki, M. & Goldberg, M.E. The representation of visual salience in monkey parietal cortex. Nature 391, 481-484 (1998).
28. Platt, M.L. & Glimcher, P.W. Responses of intraparietal neurons to saccadic targets and visual distractors. J. Neurophysiol. 78, 1574-1589 (1997).
29. Pare, M. & Wurtz, R.H. Progression in neuronal processing for saccadic eye movements from parietal cortex area lip to superior colliculus. J. Neurophysiol. 85, 2545-2562 (2001).
30. Gold, J.I. & Shadlen, M.N. Neural computations that underlie decisions about sensory stimuli. Trends Cogn. Sci. 5, 10-16 (2001).
31. Schiller, P.H. & Tehovnik, E.J. Look and see: how the brain moves your eyes about. Prog. Brain Res. 134, 127-142 (2001).
32. Burman, D.D. & Bruce, C.J. Suppression of task-related saccades by electrical stimulation in the primate's frontal eye field. J. Neurophysiol. 77, 2252-2267 (1997).
33. Opris, I., Barborica, A. & Ferrera, V.P. Effects of electrical microstimulation in monkey frontal eye field on saccades to remembered targets. Vision Res. 45, 3414-3429 (2005).
34. Romo, R., Hernandez, A. & Zainos, A. Neuronal correlates of a perceptual decision in ventral premotor cortex. Neuron 41, 165-173 (2004).
35. Kim, J.-N. & Shadlen, M.N. Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque. Nat. Neurosci. 2, 176-185 (1999).
36. Horwitz, G.D. & Newsome, W.T. Target selection for saccadic eye movements: prelude activity in the superior colliculus during a direction-discrimination task. J. Neurophysiol. 86, 2543-2558 (2001).
37. Huk, A.C. & Shadlen, M.N. Neural activity in macaque parietal cortex reflects temporal integration of visual motion signals during perceptual decision making. J. Neurosci. 25, 10420-10436 (2005).
38. Carello, C.D. & Krauzlis, R.J. Manipulating intent: evidence for a causal role of the superior colliculus in target selection. Neuron 43, 575-583 (2004).
39. Eskandar, E.N. & Assad, J.A. Dissociation of visual, motor and predictive signals in parietal cortex during visual guidance. Nat. Neurosci. 2, 88-93 (1999).
40. Leon, M.I. & Shadlen, M.N. Representation of time by neurons in the posterior parietal cortex of the macaque. Neuron 38, 317-327 (2003).
41. Sugrue, L.P., Corrado, G.S. & Newsome, W.T. Matching behavior and the representation of value in the parietal cortex. Science 304, 1782-1787 (2004).
42. Platt, M.L. & Glimcher, P.W. Neural correlates of decision variables in parietal cortex. Nature 400, 233-238 (1999).
43. Brainard, D.H. The psychophysics toolbox. Spat. Vis. 10, 443-446 (1997).
44. Lewis, J.W. & Van Essen, D.C. Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey. J. Comp. Neurol. 428, 112-137 (2000).
45. Van Essen, D.C. et al. An integrated software suite for surface-based analyses of cerebral cortex. J. Am. Med. Inform. Assoc. 8, 443-459 (2001).
46. Tehovnik, E.J. Electrical stimulation of neural tissue to evoke behavioral responses. J. Neurosci. Methods 65, 1-17 (1996).
47. Butovas, S. & Schwarz, C. Spatiotemporal effects of microstimulation in rat neocortex: a parametric study using multielectrode recordings. J. Neurophysiol. 90, 3024-3039 (2003).
48. Thier, P. & Andersen, R.A. Electrical microstimulation distinguishes distinct saccade-related areas in the posterior parietal cortex. J. Neurophysiol. 80, 1713-1735 (1998).
49. Smith, P. A note on the distribution of response times for a random walk with gaussian increments. J. Math. Psychol. 34, 445-459 (1990).
50. Press, W.H., Flannery, B.P., Teukolsky, S.A. & Vetterling, W.T. Numerical Recipes in C 755 (Cambridge University Press, Cambridge, UK, 1988).