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Volumn 1069, Issue , 2006, Pages 401-413

DHEA metabolism in arthritis: A role for the p450 enzyme Cyp7b at the immune-endocrine crossroad

Author keywords

Cyp7b; Cytokines; DHEA 7 hydroxylase; IL 1 ; Rheumatoid arthritis; TNF

Indexed keywords

7ALPHA HYDROXYPRASTERONE; ANDROGEN; COLLAGEN; CYTOCHROME P450; CYTOCHROME P450 7B; ESTROGEN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PRASTERONE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 33745621614     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1351.038     Document Type: Conference Paper
Times cited : (14)

References (35)
  • 1
    • 0035079874 scopus 로고    scopus 로고
    • Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role
    • STRAUB, R.H. & M. CUTOLO. 2001. Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum. 44: 493-507.
    • (2001) Arthritis Rheum. , vol.44 , pp. 493-507
    • Straub, R.H.1    Cutolo, M.2
  • 2
    • 0035118896 scopus 로고    scopus 로고
    • Androgens indirectly accelerate thymocyte apoptosis
    • DULOS, G.J. & W.M. BAGCHUS. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int. Immunopharmacol. 1: 321-328.
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 321-328
    • Dulos, G.J.1    Bagchus, W.M.2
  • 3
    • 0032781753 scopus 로고    scopus 로고
    • Immunological properties of dehydroepiandrosterone, its conjugates, and metabolites
    • BRADLOW, H.L., J. MURPHY & J.J. BYRNE. 1999. Immunological properties of dehydroepiandrosterone, its conjugates, and metabolites. Ann. N. Y. Acad. Sci. 876: 91-101.
    • (1999) Ann. N. Y. Acad. Sci. , vol.876 , pp. 91-101
    • Bradlow, H.L.1    Murphy, J.2    Byrne, J.J.3
  • 4
    • 0036307319 scopus 로고    scopus 로고
    • Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis
    • CUTOLO, M., B. SERIOLO, B. VILLAGGIO, et al. 2002. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 966: 131-142.
    • (2002) Ann. N. Y. Acad. Sci. , vol.966 , pp. 131-142
    • Cutolo, M.1    Seriolo, B.2    Villaggio, B.3
  • 5
    • 0031950010 scopus 로고    scopus 로고
    • Effects of dehydroepiandrosterone administration on disease activity in patients with rheumatoid arthritis
    • GILTAY, E.J., D. VAN SCHAARDENBURG, L.J. GOOREN, et al. 1998. Effects of dehydroepiandrosterone administration on disease activity in patients with rheumatoid arthritis. Br. J. Rheumatol. 37: 705-706.
    • (1998) Br. J. Rheumatol. , vol.37 , pp. 705-706
    • Giltay, E.J.1    Van Schaardenburg, D.2    Gooren, L.J.3
  • 6
    • 0030905824 scopus 로고    scopus 로고
    • Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosterone
    • WILLIAMS, P.J., R.H. JONES & T. W. RADEMACHER. 1997. Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosterone. Arthritis Rheum. 40: 907-911.
    • (1997) Arthritis Rheum. , vol.40 , pp. 907-911
    • Williams, P.J.1    Jones, R.H.2    Rademacher, T.W.3
  • 7
    • 0035892908 scopus 로고    scopus 로고
    • Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice
    • Du, C., M.W. KHALIL & S. SRIRAM. 2001. Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice. J. Immunol. 167: 7094-7101.
    • (2001) J. Immunol. , vol.167 , pp. 7094-7101
    • Du, C.1    Khalil, M.W.2    Sriram, S.3
  • 8
    • 0025284590 scopus 로고
    • Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells
    • DAYNES, R.A., D.J. DUDLEY & B.A. ARANEO. 1990. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur. J. Immunol. 20: 793-802.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 793-802
    • Daynes, R.A.1    Dudley, D.J.2    Araneo, B.A.3
  • 9
    • 0028206488 scopus 로고
    • Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice
    • MORFIN, R. & G. COURCHAY. 1994. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J. Steroid Biochem. Mol. Biol. 50: 91-100.
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.50 , pp. 91-100
    • Morfin, R.1    Courchay, G.2
  • 10
    • 0032516772 scopus 로고    scopus 로고
    • The steroid hormone dehydroepiandrosterone (DHEA) breaks intranasally induced tolerance, when administered at time of systemic immunization
    • WOLVERS, D.A., J.M. BARKER, W.M. BAGCHUS & G. KRAAL. 1998. The steroid hormone dehydroepiandrosterone (DHEA) breaks intranasally induced tolerance, when administered at time of systemic immunization. J. Neuroimmunol. 89: 19-25.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 19-25
    • Wolvers, D.A.1    Barker, J.M.2    Bagchus, W.M.3    Kraal, G.4
  • 11
    • 0030090926 scopus 로고    scopus 로고
    • Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis
    • WILDER, R.L. 1996. Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis. J. Rheumatol. 44(Suppl): 10-12.
    • (1996) J. Rheumatol. , vol.44 , Issue.SUPPL. , pp. 10-12
    • Wilder, R.L.1
  • 12
    • 0034124497 scopus 로고    scopus 로고
    • Dexamethasone-induced apoptosis of mouse thymocytes: Prevention by native 7alpha-hydroxysteroids
    • CHMIELEWSKI, V., F. DRUPT & R. MORFIN. 2000. Dexamethasone-induced apoptosis of mouse thymocytes: prevention by native 7alpha-hydroxysteroids. Immunol. Cell Biol. 78: 238-246.
    • (2000) Immunol. Cell Biol. , vol.78 , pp. 238-246
    • Chmielewski, V.1    Drupt, F.2    Morfin, R.3
  • 13
    • 0036217056 scopus 로고    scopus 로고
    • Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses
    • MORFIN, R. 2002. Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses. J. Steroid Biochem. Mol. Biol. 80: 273-290.
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.80 , pp. 273-290
    • Morfin, R.1
  • 14
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • CHIANG, J.Y.L. 1998. Regulation of bile acid synthesis. Front. Biosci. 3: D176-D193.
    • (1998) Front. Biosci. , vol.3
    • Chiang, J.Y.L.1
  • 15
    • 0035076216 scopus 로고    scopus 로고
    • Genes involved in initial steps of bile acid synthesis
    • BJORKHEM, I. & G. EGGERTSEN. 2001. Genes involved in initial steps of bile acid synthesis. Curr. Opin. Lipidol. 12: 97-103.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 97-103
    • Bjorkhem, I.1    Eggertsen, G.2
  • 16
    • 0036887723 scopus 로고    scopus 로고
    • Steroid and sterol 7-hydroxylation: Ancient pathways
    • LATHE, R. 2002. Steroid and sterol 7-hydroxylation: ancient pathways. Steroids 67: 967-977.
    • (2002) Steroids , vol.67 , pp. 967-977
    • Lathe, R.1
  • 17
    • 0029589217 scopus 로고
    • A novel cytochrome P450 expressed primarily in brain
    • STAPLETON, G., M. STEEL, M. RICHARDSON, et al. 1995. A novel cytochrome P450 expressed primarily in brain. J. Biol. Chem. 270: 29739-29745.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29739-29745
    • Stapleton, G.1    Steel, M.2    Richardson, M.3
  • 18
    • 0035968215 scopus 로고    scopus 로고
    • Neurosteroid hydroxylase CYP7B: Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation
    • ROSE, K., A. ALLAN, S. GAULDIE, et al. 2001. Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. J. Biol. Chem. 276: 23937-23944.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23937-23944
    • Rose, K.1    Allan, A.2    Gauldie, S.3
  • 19
    • 0030845921 scopus 로고    scopus 로고
    • Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA
    • SCHWARZ, M., E. G. LUND, R. LATHE, et al. 1997. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J. Biol. Chem. 272: 23995-24001.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23995-24001
    • Schwarz, M.1    Lund, E.G.2    Lathe, R.3
  • 20
    • 14944348745 scopus 로고    scopus 로고
    • CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: Regulation by proinflammatory cytokines
    • DULOS, J., M.A. VAN DER VLEUTEN, A. KAVELAARS, et al. 2005. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 52: 770-778.
    • (2005) Arthritis Rheum. , vol.52 , pp. 770-778
    • Dulos, J.1    Van Der Vleuten, M.A.2    Kavelaars, A.3
  • 21
    • 5644276386 scopus 로고    scopus 로고
    • Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: Enhancement of dehydroepiandrosterone metabolism by interleukin-1beta
    • DULOS, J., E. VERBRAAK, W.M. BAGCHUS, et al. 2004. Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta. Arthritis Rheum. 50: 3346-3353.
    • (2004) Arthritis Rheum. , vol.50 , pp. 3346-3353
    • Dulos, J.1    Verbraak, E.2    Bagchus, W.M.3
  • 22
    • 0027438710 scopus 로고
    • Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
    • ELLIOTT, M.J., R.N. MAINI, M. FELDMANN, et al. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 36: 1681-1690.
    • (1993) Arthritis Rheum. , vol.36 , pp. 1681-1690
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 23
    • 0032752705 scopus 로고    scopus 로고
    • IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation
    • JOOSTEN, L.A., M.M. HELSEN, T. SAXNE, et al. 1999. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J. Immunol. 163: 5049-5055.
    • (1999) J. Immunol. , vol.163 , pp. 5049-5055
    • Joosten, L.A.1    Helsen, M.M.2    Saxne, T.3
  • 24
    • 0028861236 scopus 로고
    • Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis
    • AREND, W.P. & J.M. DAYER. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 38: 151-160.
    • (1995) Arthritis Rheum. , vol.38 , pp. 151-160
    • Arend, W.P.1    Dayer, J.M.2
  • 25
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial
    • MORELAND, L.W., M.H. SCHIFF, S.W. BAUMGARTNER, et al. 1999. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann. Intern. Med. 130: 478-486.
    • (1999) Ann. Intern. Med. , vol.130 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 26
    • 33745627245 scopus 로고    scopus 로고
    • TNFα stimulates DHEA metabolism in human fibroblast-like synoviocytes: A role for NFκB and AP-1 in the regulation of Cyp7b expression
    • In press
    • DULOS, J., A. KAPTEIN, A. KAVELAARS, et al. 2005. TNFα stimulates DHEA metabolism in human fibroblast-like synoviocytes: a role for NFκB and AP-1 in the regulation of Cyp7b expression. Arthritis Research & Therapy 7: In press.
    • (2005) Arthritis Research & Therapy , vol.7
    • Dulos, J.1    Kaptein, A.2    Kavelaars, A.3
  • 27
    • 0034047799 scopus 로고    scopus 로고
    • 7-Hydroxydehydroepiandrosterone - A natural antiglucocorticoid and a candidate for steroid replacement therapy?
    • HAMPL, R., O. LAPCIK, M. HILL, et al. 2000. 7- Hydroxydehydroepiandrosterone - a natural antiglucocorticoid and a candidate for steroid replacement therapy? Physiol. Res. 49(Suppl 1): S107-S112.
    • (2000) Physiol. Res. , vol.49 , Issue.1 SUPPL.
    • Hampl, R.1    Lapcik, O.2    Hill, M.3
  • 28
    • 0035166407 scopus 로고    scopus 로고
    • 7-Hydroxydeliydroepiandrosterone epimers in the life span
    • HAMPL, R., M. HILL & L. STARKA. 2001. 7- Hydroxydeliydroepiandrosterone epimers in the life span. J. Steroid Biochem. Mol. Biol. 78: 367-372.
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 367-372
    • Hampl, R.1    Hill, M.2    Starka, L.3
  • 29
    • 0033665414 scopus 로고    scopus 로고
    • 7 alpha-hydroxy-dehydroepiandrosterone and immune response
    • MORFIN, R., P. LAFAYE, A.C. COTILLON, et al. 2000. 7 alpha-hydroxy- dehydroepiandrosterone and immune response. Ann. N. Y. Acad. Sci. 917: 971-982.
    • (2000) Ann. N. Y. Acad. Sci. , vol.917 , pp. 971-982
    • Morfin, R.1    Lafaye, P.2    Cotillon, A.C.3
  • 30
    • 0035990278 scopus 로고    scopus 로고
    • Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: Role of CRH in peripheral inflammation
    • WEBSTER, E.L., R.M. BARRIENTOS, C. CONTOREGGI, et al. 2002. Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation. J. Rheumatol. 29: 1252-1261.
    • (2002) J. Rheumatol. , vol.29 , pp. 1252-1261
    • Webster, E.L.1    Barrientos, R.M.2    Contoreggi, C.3
  • 31
    • 0032211865 scopus 로고    scopus 로고
    • Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
    • SETCHELL, K.D., M. SCHWARZ, N.C. O'CONNELL, et al. 1998. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J. Clin. Invest. 102: 1690-1703.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1690-1703
    • Setchell, K.D.1    Schwarz, M.2    O'Connell, N.C.3
  • 32
    • 0034595650 scopus 로고    scopus 로고
    • Expression cloning of an oxysterol 7 alpha-hydroxylase selective for 24-hydroxycholesterol
    • LI-HAWKINS J., E.G. LUND, A.D. BRONSON, et al. 2000. Expression cloning of an oxysterol 7 alpha-hydroxylase selective for 24-hydroxycholesterol. J. Biol. Chem. 275: 16543-16549.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16543-16549
    • Li-Hawkins, J.1    Lund, E.G.2    Bronson, A.D.3
  • 33
    • 0033386688 scopus 로고    scopus 로고
    • Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    • Wu, Z., K.O. MARTIN, N.B. JAVITT & J.Y. CHIANG. 1999. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. J. Lipid Res. 40: 2195-2203.
    • (1999) J. Lipid Res. , vol.40 , pp. 2195-2203
    • Wu, Z.1    Martin, K.O.2    Javitt, N.B.3    Chiang, J.Y.4
  • 34
    • 0032559475 scopus 로고    scopus 로고
    • Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes
    • NORLIN, M. & K. WIKVALL. 1998. Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. Biochim. Biophys. Acta 1390: 269-281.
    • (1998) Biochim. Biophys. Acta , vol.1390 , pp. 269-281
    • Norlin, M.1    Wikvall, K.2
  • 35
    • 0030273492 scopus 로고    scopus 로고
    • Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues
    • DOOSTZADEH, J. & R. MORFIN. 1996. Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues. Steroids 61: 613-620.
    • (1996) Steroids , vol.61 , pp. 613-620
    • Doostzadeh, J.1    Morfin, R.2


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