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Volumn 50, Issue 7, 2006, Pages 2384-2394

In vivo fluconazole pharmacodynamics and resistance development in a previously susceptible Candida albicans population examined by microbiologie and transcriptional profiling

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE; MESSENGER RNA;

EID: 33745614658     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01305-05     Document Type: Article
Times cited : (35)

References (49)
  • 1
    • 33745606489 scopus 로고    scopus 로고
    • Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: Fluconazole and Candida albicans
    • Andes, D., A. Forrest, A. Lepak, J. Nett, K. Marchillo, and L. Lincoln. 2006. Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans. Antimicrob. Agents Chem. 50:2374-2383.
    • (2006) Antimicrob. Agents Chem. , vol.50 , pp. 2374-2383
    • Andes, D.1    Forrest, A.2    Lepak, A.3    Nett, J.4    Marchillo, K.5    Lincoln, L.6
  • 2
    • 23944518475 scopus 로고    scopus 로고
    • A simple approach for estimating gene expression of Candida albicans directly from a systemic infection site
    • Andes, D., A. Lepak, A. Pitula, K. Marchillo, and J. Clark. 2005. A simple approach for estimating gene expression of Candida albicans directly from a systemic infection site. J. Infect. Dis. 192:893-900.
    • (2005) J. Infect. Dis. , vol.192 , pp. 893-900
    • Andes, D.1    Lepak, A.2    Pitula, A.3    Marchillo, K.4    Clark, J.5
  • 3
    • 0032828929 scopus 로고    scopus 로고
    • Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis model
    • Andes, D., and M. Van Ogtrop. 1999. Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis model. Antimicrob. Agents Chemother. 43:2116-2120.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2116-2120
    • Andes, D.1    Van Ogtrop, M.2
  • 4
    • 0037378033 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of antifungal drugs in treatment of candidiasis
    • Andes, D. 2003. In vivo pharmacodynamics of antifungal drugs in treatment of candidiasis. Antimicrob. Agents Chemother. 47:1179-1186.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1179-1186
    • Andes, D.1
  • 5
    • 8444232765 scopus 로고    scopus 로고
    • Emerging fungal resistance
    • Baddley, J. W., and S. A. Moser. 2004. Emerging fungal resistance. Clin. Lab. Med. 24:721-735.
    • (2004) Clin. Lab. Med. , vol.24 , pp. 721-735
    • Baddley, J.W.1    Moser, S.A.2
  • 6
    • 4444231806 scopus 로고    scopus 로고
    • Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans
    • Barker, K. S., S. Crisp, R. E. Wiederhold, R. E. Lewis, B. Bareither, J. Eckstein, R. Barbuch, M. Bard, and P. D. Rogers. 2004. Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans. J. Antimicrob. Chemother. 54:376-385.
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 376-385
    • Barker, K.S.1    Crisp, S.2    Wiederhold, R.E.3    Lewis, R.E.4    Bareither, B.5    Eckstein, J.6    Barbuch, R.7    Bard, M.8    Rogers, P.D.9
  • 7
    • 0023176033 scopus 로고
    • Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance
    • Blaser, J., B. B. Stone, M. C. Groner, and S. H. Zinner. 1987. Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrob. Agents Chemother. 31:1054-1060.
    • (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 1054-1060
    • Blaser, J.1    Stone, B.B.2    Groner, M.C.3    Zinner, S.H.4
  • 8
    • 0030711752 scopus 로고    scopus 로고
    • Evaluating treatment protocols to prevent antibiotic resistance
    • Bonhoeffer, S., M. Lipsitch, and B. R. Levin. 1997. Evaluating treatment protocols to prevent antibiotic resistance. Proc. Natl. Acad. Sci. USA 94:12106-12111.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12106-12111
    • Bonhoeffer, S.1    Lipsitch, M.2    Levin, B.R.3
  • 9
    • 0023694037 scopus 로고
    • Evolution of a bacteria/plasmid association
    • Bouma, J. E., and R. E. Lenski. 1988. Evolution of a bacteria/plasmid association. Nature 335:351-352.
    • (1988) Nature , vol.335 , pp. 351-352
    • Bouma, J.E.1    Lenski, R.E.2
  • 10
    • 0033775615 scopus 로고    scopus 로고
    • Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    • Bustin, S. A. 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25:169-193.
    • (2000) J. Mol. Endocrinol. , vol.25 , pp. 169-193
    • Bustin, S.A.1
  • 12
    • 0035036088 scopus 로고    scopus 로고
    • Divergence of fitness and evolution of drug resistance in experimental populations of Candida albicans
    • Cowen, L. E., L. M. Kohn, and J. B. Anderson. 2001. Divergence of fitness and evolution of drug resistance in experimental populations of Candida albicans. J. Bacteriol. 183:2971-2978.
    • (2001) J. Bacteriol. , vol.183 , pp. 2971-2978
    • Cowen, L.E.1    Kohn, L.M.2    Anderson, J.B.3
  • 13
    • 0027457842 scopus 로고
    • Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis
    • Drusano, G. L., D. E. Johnson, M. Rosen, and H. C. Standiford. 1993. Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob. Agents Chemother. 37:483-490.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 483-490
    • Drusano, G.L.1    Johnson, D.E.2    Rosen, M.3    Standiford, H.C.4
  • 14
    • 0032517896 scopus 로고    scopus 로고
    • The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter
    • Ehrenhofer-Murray, A. E., M. U. Keller Seitz, and C. Sengstag. 1998. The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter. Yeast 14:49-65.
    • (1998) Yeast , vol.14 , pp. 49-65
    • Ehrenhofer-Murray, A.E.1    Keller Seitz, M.U.2    Sengstag, C.3
  • 15
    • 0026012331 scopus 로고
    • Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy
    • Fan-Harvard, P., D. Capano, S. M. Smith, A. Mangia, and R. H. K. Eng. 1991. Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy. Antimicrob. Agents Chemother. 35:2302-2305.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 2302-2305
    • Fan-Harvard, P.1    Capano, D.2    Smith, S.M.3    Mangia, A.4    Eng, R.H.K.5
  • 16
    • 0038414586 scopus 로고    scopus 로고
    • In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus
    • Firsov, A. A., S. N. Vostrov, I. Y. Lubenko, K. Drlica, Y. A. Portnoy, and S. H. Zinner. 2003. In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus. Antimicrob. Agents Chemother. 47:1604-1613.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1604-1613
    • Firsov, A.A.1    Vostrov, S.N.2    Lubenko, I.Y.3    Drlica, K.4    Portnoy, Y.A.5    Zinner, S.H.6
  • 17
    • 0029057714 scopus 로고
    • Development of resistance during antimicrobial therapy: A review of antibiotic classes and patient characteristics in 173 studies
    • Fish, D. N., S. C. Piscitelli, and L. H. Danziger. 1995. Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studies. Pharmacotherapy 15:279-291.
    • (1995) Pharmacotherapy , vol.15 , pp. 279-291
    • Fish, D.N.1    Piscitelli, S.C.2    Danziger, L.H.3
  • 18
    • 2442640475 scopus 로고    scopus 로고
    • Phosphorylation of glucosamine-6-phosphate synthase is important but not essential for germination and mycelial growth of Candida albicans
    • Gabriel, I., J. Olchowy, A. Stanislawska-Sachadyn, T. Mio, J. Kur, and S. Milewski. 2004. Phosphorylation of glucosamine-6-phosphate synthase is important but not essential for germination and mycelial growth of Candida albicans. FEMS Microbiol. Lett. 235:73-80.
    • (2004) FEMS Microbiol. Lett. , vol.235 , pp. 73-80
    • Gabriel, I.1    Olchowy, J.2    Stanislawska-Sachadyn, A.3    Mio, T.4    Kur, J.5    Milewski, S.6
  • 19
    • 0020412098 scopus 로고
    • Selection of aminoglycoside-resistant variants of Pseudomonas aeruginosa in an in vivo model
    • Gerber, A. U., A. P. Vastola, J. Brandel, and W. A. Craig. 1982. Selection of aminoglycoside-resistant variants of Pseudomonas aeruginosa in an in vivo model. J. Infect. Dis. 146:691-697.
    • (1982) J. Infect. Dis. , vol.146 , pp. 691-697
    • Gerber, A.U.1    Vastola, A.P.2    Brandel, J.3    Craig, W.A.4
  • 20
    • 0032080333 scopus 로고    scopus 로고
    • Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae
    • Grilley, M. M., S. D. Stock, R. C. Dickson, R. L. Lester, and J. Y. Takemoto. 1998. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J. Biol. Chem. 273:11062-11068.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11062-11068
    • Grilley, M.M.1    Stock, S.D.2    Dickson, R.C.3    Lester, R.L.4    Takemoto, J.Y.5
  • 22
    • 3342996550 scopus 로고    scopus 로고
    • Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters
    • Karababa, M., A. T. Coste, B. Rognon, J. Bille, and D. Sanglard. 2004. Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob. Agents Chemother. 48:3064-3079.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 3064-3079
    • Karababa, M.1    Coste, A.T.2    Rognon, B.3    Bille, J.4    Sanglard, D.5
  • 23
    • 0031054924 scopus 로고    scopus 로고
    • The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity
    • Lamb, D. C., D. E. Kelly, W. H. Schunck, A. Z. Shyadehi, M. Akhtar, D. J. Lowe, B. C. Baldwin, and S. L. Kelly. 1997. The mutation T315A in Candida albicans sterol 14 alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. J. Biol. Chem. 272:5682-5688.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5682-5688
    • Lamb, D.C.1    Kelly, D.E.2    Schunck, W.H.3    Shyadehi, A.Z.4    Akhtar, M.5    Lowe, D.J.6    Baldwin, B.C.7    Kelly, S.L.8
  • 24
    • 10944272743 scopus 로고    scopus 로고
    • Antibacterial resistance worldwide: Causes, challenges and responses
    • Levy, S. B., and B. Marshall. 2004. Antibacterial resistance worldwide: causes, challenges and responses. Nat. Mede. 10(Suppl. 12):S122-S129.
    • (2004) Nat. Mede. , vol.10 , Issue.SUPPL. 12
    • Levy, S.B.1    Marshall, B.2
  • 25
    • 0031057479 scopus 로고    scopus 로고
    • The population dynamics of antimicrobial chemotherapy
    • Lipsitch, M., and B. R. Levin. 1997. The population dynamics of antimicrobial chemotherapy. Antimicrob. Agents Chemother. 41:363-373.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 363-373
    • Lipsitch, M.1    Levin, B.R.2
  • 26
    • 0034652378 scopus 로고    scopus 로고
    • The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions
    • Lipsitch, M., C. T. Bergstrom, and B. R. Levin. 2000. The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions. Proc. Natl. Acad. Sci. USA 97:1938-1943.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1938-1943
    • Lipsitch, M.1    Bergstrom, C.T.2    Levin, B.R.3
  • 27
    • 0028834086 scopus 로고
    • Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
    • Livak, K. J., S. J. Flood, J. Marmaro, W. Giusti, and K. Deetz. 1995. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Appl. 4:357-362.
    • (1995) PCR Methods Appl. , vol.4 , pp. 357-362
    • Livak, K.J.1    Flood, S.J.2    Marmaro, J.3    Giusti, W.4    Deetz, K.5
  • 29
    • 0024306079 scopus 로고
    • Sequence of Candida albicans gene encoding actin
    • Losberger, C., and J. E. Ernst. 1989. Sequence of Candida albicans gene encoding actin. Nucleic Acids Res. 17:9488.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 9488
    • Losberger, C.1    Ernst, J.E.2
  • 30
    • 0036782279 scopus 로고    scopus 로고
    • Interactions among strategies associated with bacterial infection: Pathogenicity, epidemicity, and antibiotic resistance
    • Martinez, J. L., and F. Baquero. 2002. Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin. Microbiol. Rev. 15:647-679.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 647-679
    • Martinez, J.L.1    Baquero, F.2
  • 31
    • 0030964986 scopus 로고    scopus 로고
    • Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: Expression and physiological function
    • Mio, T., T. Yamada-Okabe, T. Yabe, T. Nakajima, M. Arisawa, and H. Yamada-Okabe. 1997. Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: expression and physiological function. J. Bacteriol. 179:2363-2372.
    • (1997) J. Bacteriol. , vol.179 , pp. 2363-2372
    • Mio, T.1    Yamada-Okabe, T.2    Yabe, T.3    Nakajima, T.4    Arisawa, M.5    Yamada-Okabe, H.6
  • 32
    • 0003443223 scopus 로고    scopus 로고
    • Approved standard M27-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
    • National Committee for Clinical Laboratory Standards. 1997. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard M27-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
    • (1997) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts
  • 34
    • 0036828026 scopus 로고    scopus 로고
    • Antifungal resistance in pathogenic fungi
    • Perea, S., and T. F. Patterson. 2002. Antifungal resistance in pathogenic fungi. Clin. Infect. Dis. 35:1073-1080.
    • (2002) Clin. Infect. Dis. , vol.35 , pp. 1073-1080
    • Perea, S.1    Patterson, T.F.2
  • 35
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad, R., W. P. De, A. Goffeau, and E. Balzi. 1995. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27:320-329.
    • (1995) Curr. Genet. , vol.27 , pp. 320-329
    • Prasad, R.1    De, W.P.2    Goffeau, A.3    Balzi, E.4
  • 36
    • 0030876764 scopus 로고    scopus 로고
    • Parity among the randomly amplified polymorphic DNA method, enzyme electrophoresis, and Southern blot hybridization and the repetitive DNA probe Ca3 for fingerprinting Candida albicans
    • Pujol, C., S. Joly, S. R. Lockhart, S. Noel, M. Tibayrenc, and D. R. Soll. 1997. Parity among the randomly amplified polymorphic DNA method, enzyme electrophoresis, and Southern blot hybridization and the repetitive DNA probe Ca3 for fingerprinting Candida albicans. J. Clin. Microbiol. 35:2348-2358.
    • (1997) J. Clin. Microbiol. , vol.35 , pp. 2348-2358
    • Pujol, C.1    Joly, S.2    Lockhart, S.R.3    Noel, S.4    Tibayrenc, M.5    Soll, D.R.6
  • 37
    • 0036839691 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis
    • Rogers, P. D., and S. K. Barker. 2002. Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob. Agents Chemother. 46:3412-3417.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3412-3417
    • Rogers, P.D.1    Barker, S.K.2
  • 39
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter
    • Sanglard, D., R. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter. Microbiology 143:405-416.
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, R.2    Monod, M.3    Bille, J.4
  • 40
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14 alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    • Sanglard, D., F. Ischer, L. Koymans, and J. Bille. 1998. Amino acid substitutions in the cytochrome P-450 lanosterol 14 alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob. Agents Chemother. 42:241-253.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 41
    • 0025362399 scopus 로고
    • A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae
    • Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18:3091-3092.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3091-3092
    • Schmitt, M.E.1    Brown, T.A.2    Trumpower, B.L.3
  • 42
    • 0030839556 scopus 로고    scopus 로고
    • Adaptation to the fitness cost of antibiotic resistance in Escherichia coli
    • Schrag, S. J., V. Perrot, and B. R. Levin. 1997. Adaptation to the fitness cost of antibiotic resistance in Escherichia coli Proc. R. Soc. Long B 264:1287-1291.
    • (1997) Proc. R. Soc. Long B , vol.264 , pp. 1287-1291
    • Schrag, S.J.1    Perrot, V.2    Levin, B.R.3
  • 43
    • 0343821919 scopus 로고
    • The emergence of isoniazid-resistant cultures in patients with pulmonary tuberculosis during treatment with isoniazid alone or isoniazid plus PAS
    • Selkon, J. B., S. Devadatta, K. G. Kulkarni, D. A. Mitchison, A. S. L. Narayana, C. Narayanan Nair, and K. Ramachandran. 1964. The emergence of isoniazid-resistant cultures in patients with pulmonary tuberculosis during treatment with isoniazid alone or isoniazid plus PAS. Bull. W. H. O. 31:273-294.
    • (1964) Bull. W. H. O. , vol.31 , pp. 273-294
    • Selkon, J.B.1    Devadatta, S.2    Kulkarni, K.G.3    Mitchison, D.A.4    Narayana, A.S.L.5    Narayanan Nair, C.6    Ramachandran, K.7
  • 45
    • 0029770437 scopus 로고    scopus 로고
    • Characterization of the Saccharomyces cerevisiae RTA1gene involved in 7-aminocholesterol resistance
    • Soustre, I., Y. Letourneux, and F. Karst. 1996. Characterization of the Saccharomyces cerevisiae RTA1gene involved in 7-aminocholesterol resistance. Curr. Genet. 30:121-125.
    • (1996) Curr. Genet. , vol.30 , pp. 121-125
    • Soustre, I.1    Letourneux, Y.2    Karst, F.3
  • 46
    • 0038491550 scopus 로고    scopus 로고
    • Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane
    • Umebayashi, K., and A. Nakano. 2003. Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. J. Cell Biol. 161:1117-1131.
    • (2003) J. Cell Biol. , vol.161 , pp. 1117-1131
    • Umebayashi, K.1    Nakano, A.2
  • 47
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White, T. C. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1482-1487
    • White, T.C.1
  • 48
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White, T. C., K. A. Marr, and R. A. Bowden. 1998. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11:382-402.
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 49
    • 0030914272 scopus 로고    scopus 로고
    • Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient
    • White, T. C., M. A. Pfaller, R. G. Rinaldi, J. Smith, and S. W. Redding. 1997. Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient. Oral Dis. 3(Suppl. 1):102-109.
    • (1997) Oral Dis. , vol.3 , Issue.SUPPL. 1 , pp. 102-109
    • White, T.C.1    Pfaller, M.A.2    Rinaldi, R.G.3    Smith, J.4    Redding, S.W.5


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