Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: Expression and physiological function

Journal of Bacteriology

Volumn 179, Issue 7, 1997, Pages 2363-2372

  Mio, Toshiyuki ^a   Yamada Okabe, Toshiko ^b   Yabe, Tomio ^a,c   Nakajima, Tasuku ^c   Arisawa, Mikio ^a   Yamada Okabe, Hisafumi ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAN;

ARTICLE; CANDIDA ALBICANS; CARBOHYDRATE METABOLISM; FUNGUS MUTATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE ISOLATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CANDIDA ALBICANS; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0030964986     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.7.2363-2372.1997     Document Type: Article

References (39)

1. Alani, E., L. Cao, and N. Kleckner. 1987. A method for gene disruption that allows repeated use of URA3 selection in the construction multiply disrupted yeast strains. Genetics 116:541-545.
2. Boone, C., M. Goebl, R. Puccia, A.-M. Sdicu, and H. Bussey. 1993. Yeast KRE2 defines a new gene family encoding probable secretory proteins, and is required for the correct N-glycosylation of proteins. Genetics 130:270-283.
3. Boone, C., A. M. Sdicu, M. Laroche, and H. Bussey. 1991. Isolation from Candida albicans of a functional homolog of the Saccharomyces cerevisiae KRE1 gene, which is involved in cell wall β-glucan synthesis. J. Bacteriol. 173:6859-6864.
4. Boone, C., S. S. Sommer, A. Hensel, and H. Bussey. 1990. Yeast KRE genes provide evidence for a pathway of cell wall β-glucan assembly. J. Cell Biol. 110:1833-1843.
5. Brown, J. L., and H. Bussey. 1993. The yeast KRE9 encodes an O glycoprotein involved in cell surface β-glucan assembly. Mol. Cell. Biol. 13:6346-6356.
6. Brown, J. L., Z. Kossaczka, B. Jiang, and H. Bussey. 1993. A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new genes involved in cell wall (1-6)-β-glucan synthesis. Genetics 133:837-849.
7. Brown, J. L., S. North, and H. Bussey. 1993. SKN7, a yeast multicopy suppressor of a mutation affecting cell wall β-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors. J. Bacteriol. 175:6098-6915.
8. Bulawa, C. E., D. W. Miller, L. K. Henry, and J. M. Becker. 1995. Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc. Natl. Acad. Sci. USA 92:10570-10574.
9. Cannon, R. D., K. Niimi, H. F. Jenkinson, and M. G. Shepherd. 1994. Molecular cloning and expression of the Candida albicans β-N-acetylglucosaminidase (HEX1) gene. J. Bacteriol. 176:2640-2647.
10. Douglas, C. M., F. Foor, J. A. Marrinan, N. Morin, J. B. Nielsen, A. M. Dahl, P. Mazur, W. Baginsky, W. Li, M. El-Sherbeini, J. A. Clemas, S. M. Mandala, B. R. Frommer, and M. B. Kurtz. 1994. The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-β-D-glucan synthase. Proc. Natl. Acad. Sci. USA 91:12907-12911.
11. Drgonova, J., T. Drgon, K. Tanaka, R. Kollar, G. C. Chen, R. A. Ford, C. S. Chan, Y. Takai, and E. Cabib. 1996. Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science 272:277-279.
12. Fleet, G. H. 1991. Cell walls, p. 199-277. In A. H. Rose and J. S. Harrinson (ed.), The yeasts, vol. 4. Academic Press, New York, N.Y.
13. Furukawa, K., M. Tagaya, K. Tanizawa, and T. Fukui. 1993. Role of the conserved Lys-X-Gly-Gly sequence at the ADP-glucose-binding site in Escherichia coli glycogen synthase. J. Biol. Chem. 268:23837-23842.
14. Gow, N. A. R., and G. W. Gooday. 1987. Cytological aspects of dimorphism in Candida albicans. Crit. Rev. Microbiol. 15:73-78.
15. Hausler, A., L. Ballou, C. E. Ballou, and P. W. Robbins. 1992. Yeast glycoprotein biosynthesis: MNT1 encodes an α-1,2-mannosyltransferase involved in O-glycosylation. Proc. Natl. Acad. Sci. USA 89:6846-6850.
16. Inoue, S. B., N. Takewaki, T. Takasuka, T. Mio, M. Adachi, Y. Fujii, C. Miyamoto, M. Arisawa, Y. Furuichi, and T. Watanabe. 1995. Characterization and gene cloning of 1,3-β-D-glucan synthase from Saccharomyces cerevisiae. Eur. J. Biochem. 231:845-854.
17. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
18. Jiang, B., J. Sheraton, A. F. J. Ram, G. J. P. Dijkgraaf, F. M. Klis, and H. Bussey. 1996. CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in β1,6-glucan assembly. J. Bacteriol. 178:1162-1171.
19. Kang, M. S., and E. Cabib. 1986. Regulation of fungal cell wall growth: a guanine nucleotide-binding proteinaceous component required for activity of (1,3)-β-D-glucan synthase. Proc. Natl. Acad. Sci. USA 83:5808-5812.
20. Kasahara, S., S. B. Inoue, T. Mio, T. Yamada, T. Nakajima, E. Ichishima, Y. Furuichi, and H. Yamada. 1994. Involvement of cell wall β-glucan in the action of HM-1 killer toxin. FEBS Lett. 348:27-32.
21. Kasahara, S., H. Yamada, T. Mio, Y. Shiratori, C. Miyamoto, T. Yabe, T. Nakajima, E. Ichishima, and Y. Furuichi. 1994. Cloning of the Saccharomyces cerevisiae gene whose overexpression overcomes the effects of HM-1 killer toxin, which inhibits β-glucan synthesis. J. Bacteriol. 176:1488-1499.
22. Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
23. Lussier, M., A. M. Sdicu, T. Ketela, and H. Bussey. 1995. Localization and targetting of the Saccharomyces cerevisiae Kre2p/Mnt1p α-1,2-mannosyltransferase to a medial-golgi compartment. J. Cell Biol. 131:913-927.
24. Manuel, A., S. Santos, and M. F. Tuite. 1995. The CUG codon is decoded in vivo as serine and not leucine in Candida albicans. Nucleic Acids Res. 23:1481-1486.
25. Meaden, P., K. Hill, J. Wagner, D. Slipetz, S. S. Sommer, and H. Bussey. 1990. The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1→6)-β-D-glucan synthesis and normal cell growth. Mol. Cell. Biol. 10:3013-3019.
26. Mio, T., T. Yabe, M. Sudoh, Y. Satoh, T. Nakajima, M. Arisawa, and H. Yamada-Okabe. 1996. Role of three chitin synthase genes in the growth of Candida albicans. J. Bacteriol. 178:2416-2419.
27. Mol, P. C., H.-M. Park, J. T. Mullins, and E. Cabib. 1994. A GTP-binding protein regulates the activity of (1-3)-β-glucan synthase, an enzyme directly involved in yeast cell wall morphogenesis. J. Biol. Chem. 269:31267-31274.
28. Odds, F. C. 1987. Candida infection: an overview. Crit. Rev. Microbiol. 15:1-5.
29. Parker, C. G., L. I. Fessler, R. E. Nelson, and J. H. Fessler. 1995. Drosophila UDP-glucose:glycoprotein glucosyltransferase sequence and characterization of an enzyme that distinguishes between denatured and native proteins. EMBO J. 14:1294-1303.
30. Qadota, H., C. P. Python, S. B. Inoue, M. Arisawa, Y. Anraku, Y. Zheng, T. Watanabe, D. E. Levin, and Y. Ohya. 1996. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-β-glucan synthase. Science 272:279-281.
31. Ram, A. F. J., A. Wolters, R. T. Hoopen, and F. M. Klis. 1994. A new approach for isolating cell wall mutants in Saccharomyces ccrevisiae by screening for hypersensitivity to calcofluor white. Yeast 10:1019-1030.
32. Roemer, T., and H. Bussey. 1991. Yeast β-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Proc. Natl. Acad. Sci. USA 88:11295-11299.
33. Roemer, T., and H. Bussey. 1995. Yeast Kre1p is a cell surface O-glycoprotein. Mol. Gen. Genet. 249:209-216.
34. Roemer, T., S. Delaney, and H. Bussey. 1993. SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in β-glucan synthesis. Mol. Cell. Biol. 13:4039-4048.
35. Roemer, T., G. Paravicini, M. A. Paylon, and H. Bussey. 1994. Characterization of the yeast (1-6)-β-glucan biosynthetic components, Kre6p and Skn1p, and genetic interactions between the PKC pathway and extracellular matrix assembly. J. Cell Biol. 127:567-579.
36. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
37. Shepherd, M. G. 1985. Candida albicans: biology, genetics, and pathogenicity. Annu. Rev. Microbiol. 39:579-614.
38. Sudoh, M., S. Nagahashi, M. Doi, M. Takagi, and M. Arisawa. 1993. Cloning of the chitin synthase 3 gene from Candida albicans and its expression during yeast-hyphal transition. Mol. Gen. Genet. 241:351-358.
39. Surarit, R., P. K. Gopal, and M. Shepherd. 1988. Evidence for a glycoside linkage between chitin and glucan in the cell wall of Candida albicans. J. Gen. Microbiol. 134:1723-1730.