Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity

Food and Chemical Toxicology

Volumn 44, Issue 9, 2006, Pages 1585-1589

  Santos, F V ^a   Colus, I M S ^b   Silva, M A ^a   Vilegas, W ^a   Varanda, E A ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Ames test; Micronucleus; Mutagenicity; Salmonella typhimurium; Strychnos pseudoquina

Indexed keywords

ALKALOID; ANTIULCER AGENT; DICHLOROMETHANE; FLAVONOID; METHANOL; PLANT EXTRACT; STRYCHNOS PSEUDOQUINA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL; BODY WEIGHT; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG MEGADOSE; FEMALE; GENOTOXICITY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MICRONUCLEUS; MOUSE STRAIN; MUTAGENICITY; NONHUMAN; PLANT LEAF; SALMONELLA TYPHIMURIUM;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ULCER AGENTS; CHEMICAL FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; METHANOL; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENS; PLANT EXTRACTS; PLANTS, MEDICINAL; RETICULOCYTES; RIBOSOMAL PROTEINS; SALMONELLA TYPHIMURIUM; STRYCHNOS;

ANIMALIA; SALMONELLA; SALMONELLA TYPHIMURIUM; STRYCHNOS PSEUDOQUINA;

EID: 33745606426     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.03.012     Document Type: Article

References (31)

1. Agrawal P.K. Carbon 13 NMR of Flavonoids. first ed. vol. XXXIX (1989), Elsevier, Amsterdam
2. Andrade-Neto V.F., Brandão M.G.L., Stehmann J.R., Oliveira L.A., and Krettli A.U. Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. J. Ethnopharmacol. 87 (2003) 253-256
3. Ansah C., Khan A., and Gooderham N.J. In vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine. Toxicology 208 (2005) 141-147
4. Bernstein L., Kaldor J., McCann J., and Pike M.C. An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test. Mutat. Res 97 (1982) 267-281
5. Correa, P.M., 1926. Dicionário das Plantas Úteis do Brasil e das Exóticas Cultivadas, first ed. vol. VI, Imprensa Oficial, Rio de Janeiro.
6. Delaney B., Phillips K., Vasquez C., Wilson A., Cox D., Wang H.B., and Manthey J. Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. Food Chem. Toxicol. 40 5 (2002) 617-624
7. Delle-Monache F., Aldo P.T., and Bettolo G.B.M. Occurrence of nor-dehydrotoxiferine in Strychnos pseudoquina St. Hil. Tetrahedron Lett. 25 (1969) 2009-2012
8. Frederich M., Hayette M.P., Tits M., De Mol P., and Angenot L. In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum. Antimicrob. Agents Chemother. 43 (1999) 2328-2331
9. Fu P.P., Xia Q., Lin G., and Chou M.W. Pyrrolizidine alkaloids - genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug. Metab. Rev. 31 1 (2004) 1-55
10. Harborne J.B. The Flavonoids. first ed. Advances in Research Since 1986 (1993), Chapman and Hall, London
11. Hayashi M., Morita T., Kodama Y., Sofuni T., and Ishidate Jr. M. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 245 (1990) 245-249
12. Huynh H.T., and Teel R.W. In vitro antimutagenicity of capsaicin toward heterocyclic amines in Salmonella typhimurium strain TA98. Anticancer Res. 25 1A (2005) 117-120
13. Jurado J., Alejandre-Duran E., Alonso-Moraga A., and Pueyo C. Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test. Mutagenesis 6 4 (1991) 289-295
14. Kingston D.G., Gerhart B.B., Ionescu F., Mangino M.M., and Sami S.M. Plant anticancer agents V: new bisindole alkaloids from Tabernaemontana johnstonii stem bark. J. Pharm. Sci. 67 2 (1978) 249-251
15. Krishna G., and Hayashi M. In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutat. Res. 455 (2000) 155-166
16. 13C NMR Spectra of pentacyclic triterpenoids - a compilation and some salient features. Phytochemistry 37 (1994) 1517-1575
17. Maron D.M., and Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113 (1983) 173-215
18. Mei N., Heflich R.H., Chou M.W., and Chen T. Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats. Chem. Res. Toxicol. 17 (2004) 814-818
19. Mori H., Sugie S., Yoshimi N., Asada Y., Furuya T., and Williams G.M. Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes. Cancer Res. 45 (1985) 3125-3129
20. Mortelmans K., and Zeiger E. The Ames Salmonella/Microsome mutagenicity assay. Mutat. Res. 455 1-2 (2000) 29-60
21. Nicoletti M., Goulart M.O., Lima R.A., Goulart A.E., Delle Monache F., and Marini-Bettolo G.B. Flavonoids and alkaloids from Strychnos pseudoquina. J. Nat. Prod. 47 6 (1984) 953-957
22. Park S., Hahm K.B., Oh T.Y., Jin J.H., and Choue R. Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 49 3 (2004) 384-394
23. Philippe G., Angenot L., Tits M., and Frèdèrich M. About the toxicity of some Strychnos species and their alkaloids. Toxicon 44 (2004) 405-416
24. Proudlock R., Thompson C., and Longstaff E. Examination of the potential genotoxicity of pure capsaicin in bacterial mutation, chromosome aberration, and rodent micronucleus tests. Environ. Mol. Mutagen. 44 5 (2004) 441-447
25. Silva M.A., Rafacho B.P., Hiruma-Lima C.A., Rocha L.R.M., Brito A.R.M.S., and Vilegas W. Evaluation for Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice. Chem. Pharm. Bull. 53 8 (2005) 881-885
26. Suzuki S., Takada T., Sugawara Y., Muto T., and Kominami R. Quercetin induces recombinational mutations in cultured cells as detected by DNA fingerprinting. Japan. J. Cancer Res. 82 10 (1991) 1061-1064
27. Thongphasuk P., Suttisri R., Bavovada R., and Verpoort R. Alkaloids and a pimarane diterpenoid from Strychnos vanprukii. Phytochemistry 64 (2003) 897-901
28. Toker G., Küpeli E., Memisoglu M., and Yesilada E. Flavonoids with antinociceptive and anti-inflammatory activities from the leaves of Tilia argentea (silver linden). J. Ethnopharmacol. 95 (2004) 393-397
29. Varella S.D., Pozetti G.L., Vilegas W., and Varanda E.A. Mutagenic activity of sweepings and pigments a household-wax factory assayed with Salmonella typhimurium. Food Chemical Toxicol. 42 (2004) 2029-2035
30. Vargas V.M.F., Motta V.E.P., and Henriques J.A.P. Mutagenic activity detected by the Ames test in river water the influence of petrochemical industries. Mutat.Res. 319 (1993) 31-45
31. Wang C., and Peng C. The mutagenicities of alkaloids and N-nitrosoguvacoline from betel quid. Mutat. Res. 360 (1996) 165-171