Anti-Herpes Simplex Virus Activity of Substituted 1-Hydroxyacridones

Journal of Medicinal Chemistry

Volumn 46, Issue 23, 2003, Pages 5015-5020

  Lowden, Christopher T ^a,b   Bastow, Kenneth F ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Pharmaceutical Product Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYACRIDONE; 5 CHLORO 1,3 DIHYDROXYACRIDONE; 5 METHOXY 1,3 DIHYDROXYACRIDONE; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HYPOTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; VIRUS STRAIN;

EID: 0242299580     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030206l     Document Type: Article

References (15)

1. Akanitapichat, P.; Lowden, C. T.; Bastow, K. F. 1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication. Antiviral Res. 2000, 45, 123-134.
2. Akanitapichat, P.; Bastow, K. F. The Antiviral Agent 5-Chloro-1,3-dihydroxyacridone Interferes with Assembly and Maturation of Herpes Simplex Virus. Antiviral Res. 2002, 53, 113-126.
3. Cavert, W. Viral Infections in Human Immunodeficiency Virus Disease. Med. Clin. North Am. 1997, 81, 411-426.
4. Baba, M. Cellular targets as alternative Targets for inhibition of HIV-1. Antiviral Res. 1997, 33: 141-152.
5. Erice, A. Resistance of Human Cytomegalovirus to Antiviral Drugs. Clin. Microbiol. Rev. 1999, 12, 286-297.
6. Bastow, K. F.; Itoigawa, M.; Furukawa, H.; Kashiwada, Y.; Bori, I. D.; Ballas, L. M.; Lee, K.-H. Antiproliferative Actions of 7-Substituted 1,3-Dihydroxyacridones; Possible Involvement in DNA Topoisomerase II and Protein Kinase C as Biochemical Targets. Bioorg. Med. Chem. 1995, 2, 1403-1411.
7. Lowden, C. T. Synthesis and Biological Evaluation of 1,3-Dihydroxyacridones; Inhibition of Cell Growth and Mammalian Topoisomerase II. UNC-Chapel Hill, September, 1995.
8. Van Zeijl, M.; Fairhurst, J.; Jones, T. R.; Vernon, S. K.; Morin, J.; LaRocque, J.; Feld, B.; O'hara, B.; Bloom, J. D.; Johann, S. V. Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: resistance maps to UL6 gene. J. Virol. 2000, 74, 9054-9061.
9. Hlubucek, J. R.; Ritchie, E.; Taylor; W. C. Synthesis of acronycine. Aust. J. Chem. 1970, 23, 1881-1889.
10. Smolders, R. R.; Hanuise, J.; Voglet, N. Synthesis of some Hydroxylated 9-acridanones. Bull. Soc. Chim. Belg. 1984, 93, 239-240.
11. Adams, J. H.; Gupta, P.; Shafig, K. M.; Lewis, J. R.; Watt, R. A. Intramolecular Cyclization of 2-Aminobenzophenones; a New 9-Acridone Synthesis. J. Chem., Perkin Trans. 1976, 2089-2093.
12. Reisch, J.; Dziemba, P. Natural Product Chemistry. Part 153-[1]. Synthesis and Possible Antitumor Activity of 8-Nitroacronycine. J. Heterocycl. Chem. 1992, 29, 1293-1296.
13. Russell, W. C. A Sensitive and Precise Plaque Assay for Herpes Virus. Nature 1962, 195, 1028-1029.
14. Su, T.-L.; Kohler, B.; Chou, T.-C.; Chun, M. W.; Watanabe, K. A. Synthesis of the Acridone Alkaloids Glyfoline and Congeners. Structure-Activity Relationship Studies of Cytotoxic Acridones. J. Med. Chem. 1992, 35, 2703-2710.
15. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenny, S.; Boyd, M. R. New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer. Inst. 1990, 82, 1107-1112.