Regenerative medicine: Using liver to generate pancreas for treating diabetes

Israel Medical Association Journal

Volumn 8, Issue 6, 2006, Pages 430-434

  Meivar Levy, Irit ^a,b   Ferber, Sarah ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Diabetes; Hepatocytes; Insulin; Liver; NeuroD 1 beta2; Pancreas; PDX 1; Trans differentiation

Indexed keywords

BETACELLULIN; GLUCOSE; NEUROGENIC DIFFERENTIATION FACTOR; REGULATOR PROTEIN; TRANSCRIPTION FACTOR PDX 1;

ALLOTRANSPLANTATION; DIABETES CONTROL; DIABETES MELLITUS; DIABETIC PATIENT; EMBRYO CELL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER; NONHUMAN; PANCREAS; PANCREAS ISLET TRANSPLANTATION; REGENERATIVE MEDICINE; REVIEW; STEM CELL; TISSUE REGENERATION;

ADULT; CELL DIFFERENTIATION; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER; PLURIPOTENT STEM CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 33745598512     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Stock PG, Bluestone JA. Beta-cell replacement for type I diabetes. Annu Rev Med 2004;55:133-56.
2. Thomas MK, Habener JF. Pancreas development. In: Gill RG, ed. Immunologically Mediated Endocrine Diseases. Baltimore MD: Lippincott Williams & Wilkins, 2002:141-424.
3. Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab 2003;284(2):E259-66.
4. Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet 2004;364(9429):203-5.
5. Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6(5):568-72.
6. Bet I, Shternhall K, Perl S, et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 2003;278(34):31950-7.
7. Sapir T, Shternhall K, Meivar-Levy I, et al. From the cover: cell-replacement therapy for diabetes. Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA 2005;102(22):7964-9.
8. Horb ME, Shen CN, Tosh D, Slack JM. Experimental conversion of liver to pancreas. Curr Biol 2003;13(2):105-15.
9. Imai J, Katagiri H, Yamada T, et al. Constitutively active PDX1 induced efficient insulin production in adult murine liver. Biochem Biophys Res Commun 2005;326(2):402-9.
10. Kaneto H, Nakatani Y, Miyatsuka T, et al. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005;54(4):1009-22.
11. Kaneto H, Matsuoka TA, Nakatani Y, et al. A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem 2005; 280(15):15047-52.
12. Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9(5):596-603.
13. Li WC, Horb ME, Tosh D, Slack JM. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech Dev 2005;122(6):835-47.
14. Miyatsuka T, Kaneto H, Kajimoto Y, et al. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 2003;310(3):1017-25.
15. Yang L, Li S, Hatch H, et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 2002;99(12):8078-83.
16. Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived, insulin-producing cells toward the (beta)-cell phenotype. Diabetes 2005;54(9):2568-75.
17. Zalzman M, Gupta S, Giri RK, et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 2003;100(12):7253-8.
18. Desmet VJ. Organization principles. In: Arias IM, Boyer JL, Chisari FV, et al., eds. The Liver; Biology and Pathobiology. Philadelphia: Lippincott Williams & Wilkins, 2001:3-15.
19. Thorgeirsson SS. Hepatic stem cells in liver regeneration. FASEB J 1996;10(11):1249-56.
20. Deutsch G, Jung J, Zheng M, Lora J, Zaret JS. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001;128:871-81.
21. Otsuka M, Hoshida Y, Kato N, et al. Liver chip and gene shaving. J Gastroenterol 2003;38(Suppl 15):89-92.
22. Shen CN, Slack JM, Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2000;2:879-88.
23. Yang H, Morrison CM, Conlon JM, Laybolt K, Wright JR Jr. Immunocytochemical characterization of the pancreatic islet cells of the Nile Tilapia (Oreochromis niloticus). Gen Comp Endocrinol 1999; 114(1):47-56.
24. Kito H, Ose Y, Mizuhira V, Sato T, Ishikawa T, Tazawa T. Separation and purification of (Cd, Cu, Zn)-metallothionein in carp hepato-pancreas. Comp Biochem Physiol C 1982:73(1):121-7
25. Weintraub H, Tapscott SJ, Davis RL, et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci USA 1989;86(14):5434-8.
26. Tarpin M, Gehring WJ, Bierne J. Conversion of a postocellar into an ocellar region as a transdetermination event occurring in adult ribbonworms. Mech Dev 2002;118(1-2):39-44.
27. McKinnon CM, Docherty K. Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function. Diabetologia 2001;44(10):1203-14.
28. Hui H, Perfetti R. Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. Eur J Endocrinol 2002;146(2):129-41.
29. Slack JM, Tosh D. Transdifferentiation and metaplasia - switching cell types. Curr Opin Genet Dev 2001;11(5):581-6.
30. Jungermann K. Metabolic zonation of liver parenchyma: significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis. Diabetes Metab Rev 1987;3(1):269-93.
31. Chakrabarti SK, Mirmira RG. Transcription factors direct the development and function of pancreatic b-cells. Trends Endocrinol Metab 2003;14(2):78-84.
32. Mosley AL, Ozcan S Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem 2003;278(22): 19660-6.
33. Hall DB, Struhl K. The VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo. J Biol Chem 2002;277(48):46043-50.
34. Memedula S, Belmont AS. Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16. Curr Biol 2003;13(3):241-6.
35. Naya FJ, Huang HP, Qiu Y, et al. Diabetes, defective pancreatic morphogenisis, and abnormal enteronendocrine differentiation in BETA2/ NeuroD-deficient mice. Genes Dev 1997;11:2323-34.
36. Demeterco C, Beattie GM, Dib SA, Lopez AD, Hayek A. A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J Clin Endocrinol Metab 2000;85(10):3892-7.
37. Hayek A, Beattie GM, Cirulli V, et al. Growth factor/matrix-induced proliferation of adult beta-cells. Diabetes 1995;44(12):1458-60.
38. Sigal SH, Brill S, Fiorino AS, Reid LM. The liver as a stem cell and lineage system. Am J Physiol 1992;263:G139-48.
39. Grafi G. How cells dedifferentiate: a lesson from plants. Dev Biol 2004;268(1):1-6.
40. Cozar-Castellano I, Stewart AF. Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy. Proc Natl Acad Sci USA 2005;102(22):7781-2.