Effects of swimming on functional recovery after incomplete spinal cord injury in rats

Journal of Neurotrauma

Volumn 23, Issue 6, 2006, Pages 908-919

  Smith, Rebecca R ^a   Shum Siu, Alice ^a   Baltzley, Ryan ^a   Bunger, Michelle ^a   Baldini, Angela ^a   Burke, Darlene A ^a   Magnuson, David S K ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Contusion injury; Re training; Rehabilitation; Swimming

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONTUSION; HINDLIMB; MOTOR PERFORMANCE; NONHUMAN; RAT; SPINAL CORD INJURY; SWIMMING; TREADMILL EXERCISE; WALKING;

ANIMALS; BIOFEEDBACK (PSYCHOLOGY); BIOMECHANICS; FEMALE; LOCOMOTION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; SWIMMING;

EID: 33745499219     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.23.908     Document Type: Article

References (35)

1. ABEL, R., SCHABLOWSKI, M., RUPP, R., and GERNER, H.J. (2002). Gait analysis on the treadmill-monitoring exercise in the treatment of paraplegia. Spinal Cord 40, 17-22.
2. BARBEAU, H., WAINBERG, M., and FINCH, L. (1987). Description and application of a system for locomotor rehabilitation. Med. Biol. Eng. Comput. 25, 341-344.
3. BASSO, D.M., BEATTIE, M.S., and BRESNAHAN, J.C. (1995). A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1-21.
4. BASSO, D.M., BEATTIE, M.S., and BRESNAHAN, J.C. (1996). Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139, 244-256.
5. BOUYER, L.J., and ROSSIGNOL, S. (2003). Contribution of cutaneous inputs from the hindpaw to the control of locomotion. II. Spinal cats. J. Neurophysiol. 90, 3640-3653.
6. DE LEON, R.D., HODGSON, J.A., ROY, R.R., and EDGERTON, V.R. (1998a). Locomotor capacity attributable to step training versus spontaneous recovery following spinalization in adult cats. J. Neurophysiol. 79, 1329-1340.
7. DE LEON, R.D., HODGSON, J.A., ROY, R.R., and EDGERTON, V.R. (1998b). Full weight-bearing hindlimb standing following standtraining in the adult spinal cat. J. Neurophysiol. 80, 83-91.
8. DIETZ, V., COLOMBO, G., and JENSEN, L. (1994). Locomotor activity in spinal man. Lancet 344, 1260-1263.
9. DIETZ, V., COLOMBO, G., JENSEN, L., and BAUMGARTNER, L. (1995). Locomotor capacity of spinal cord in paraplegic patients. Ann. Neurol. 37, 574-582.
10. EDGERTON, V.R., ROY, R.R., HODGSON, J.A., PROBER, R.J., DE GUZMAN, C.P., and DE LEON, R. (1992). Potential of adult mammalian lumbosacral spinal cord to execute and acquire improved locomotion in the absence of supraspinal input. J. Neurotrauma 9, Suppl 1, S119-S128.
11. GOMEZ-PINILLA, F., YING, Z., ROY, R.R., MOLTENI, R., and EDGERTON, V.R. (2002). Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. 88, 2187-2195.
12. GRILLNER, S. (1975). Locomotion in vertebrates: central mechanisms and reflex interaction. Physiol. Rev. 55, 247-304.
13. GRILLNER, S., and ZANGGER, P. (1984). The effect of dorsal root transection on the efferent motor pattern in the cat's hindlimb during locomotion. Acta Physiol. Scand. 120, 393-405.
14. GRILLNER, S., and ZANGGER, P. (1975). How detailed is the central generator for locomotion? Brain Res. 88, 367-371.
15. HADI, B., ZHANG, Y.P., BURKE, D.A., SHIELDS, C.B., and MAGNUSON, D.S. (2000). Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: no direct correlation with motor neuron loss. J. Neurosurg. 93, 266-275.
16. HADI, B., ZHANG, Y.P., BURKE, D.A., SHIELDS, C.B., and MAGNUSON, D.S. (2000). Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: no direct correlation with motor neuron loss. J. Neurosurg. 93, 266-275.
17. HARKEMA, S.J., HURLEY, S.L., PATEL, U.K., REQUEJO, P.S., DOBKIN, B.H., and EDGERTON, V.R. (1997). Human lumbosacral spinal cord interprets loading during stepping. J. Neurophysiol. 77, 797-811.
18. HIEBERT, G.W., and PEARSON, K.G. (1999). Contribution of sensory feedback to the generation of extensor activity during walking in the decerebrate cat. J. Neurophysiol. 81, 758-770.
19. HICKS, A.L., MARTIN, K.A., DITOR, D.S., et al. (2003). Long-term exercise training in persons with spinal cord injury: effects on strength, arm ergometry performance and psychological well-being. Spinal Cord 41, 34-43.
20. HUTCHINSON, K.J., GOMEZ-PINILLA, F., CROWE, M.J., YING, Z., and BASSO, D.M. (2004). Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Brain 127, 1403-1414.
21. JORDAN, L.M. (1998). Initiation of locomotion in mammals. Ann. N.Y. Acad. Sci. 860, 83-93.
22. LANKHORST, A.J., TER LAAK, M.P., VAN LAAR, T.J., et al. (2001). The effects of enriched housing on functional recovery after spinal cord contusive injury in the adult rat. J. Neurotrauma 18, 203-215.
23. LOY, D.N., MAGNUSON, D.S., ZHANG, Y.P., et al. (2002). Functional redundancy of ventral spinal locomotor pathways. J. Neurosci. 22, 315-323.
24. MAEGELE, M., MULLER, S., WERNIG, A., EDGERTON, V.R., and HARKEMA, S.J. (2002). Recruitment of spinal motor pools during voluntary movements versus stepping after human spinal cord injury. J. Neurotrauma 19, 1217-1229.
25. MAGNUSON, D.S., TRINDER, T.C., ZHANG, Y.P., BURKE, D., MORASSUTTI, D.J., and SHIELDS, C.B. (1999). Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat. Exp. Neurol. 156, 191-204.
26. MAGNUSON, D.S., LOVETT, M.R., COFFEE, C., et al. (2005). Functional consequences of lumbar spinal cord contusion injuries in the adult rat. J. Neurotrauma. 22, 529-543.
27. MUIR, G.D., and STEEVES, J.D. (1995). Phasic cutaneous input facilitates locomotor recovery after incomplete spinal injury in the chick. J. Neurophysiol. 74, 358-368.
28. MULTON, S., FRANZEN, R., POIRRIER, A.L., SCHOLTES, F., and SCHOENEN, J. (2003). The effect of treadmill training on motor recovery after a partial spinal cord compression-injury in the adult rat. J. Neurotrauma 20, 699-706.
29. NOGA, B.R., KRIELLAARS, D.J., and JORDAN, L.M. (1991). The effect of selective brainstem or spinal cord lesions on treadmill locomotion evoked by stimulation of the mesencephalic or pontomedullary locomotor regions. J. Neurosci. 11, 1691-1700.
30. PEARSON, K.G. (1993). Common principles of motor control in vertebrates and invertebrates. Annu. Rev. Neurosci. 16, 265-297.
31. PEPIN, A., NORMAN, K.E., and BARBEAU, H. (2003). Treadmill walking in incomplete spinal-cord-injured subjects: 1. Adaptation to changes in speed. Spinal Cord 41, 257-270.
32. SCHUCHT, P., RAINETEAU, O., SCHWAB, M.E., and FOUAD, K. (2002). Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp. Neurol. 176, 143-153.
33. SHEFCHYK, S., MCCREA, D., KRIELLAARS, D., FORTIER, P., and JORDAN, L. (1990). Activity of interneurons within the L4 spinal segment of the cat during brainstem-evoked fictive locomotion. Exp. Brain Res. 80, 290-295.
34. SHIK, M.L., SEVERIN, F.V., and ORLOVSKII, G.N. (1966). [Control of walking and running by means of electric stimulation of the midbrain]. Biofizika 11, 659-666.
35. VAN MEETEREN, N.L., EGGERS, R., LANKHORST, A.J., GISPEN, W.H., and HAMERS, F.P. (2003). Locomotor recovery after spinal cord contusion injury in rats is improved by spontaneous exercise. J. Neurotrauma 20, 1029-1037.