A review of in vitro-in vivo investigations on dendrimers: the novel nanoscopic drug carriers

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 2, Issue 2, 2006, Pages 66-73

  Gupta, Umesh ^a   Agashe, Hrushikesh Bharat ^a   Asthana, Abhay ^a   Jain, Narendra K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Dendrimers; Drug delivery; Nanoscopic drug carriers; Routes of administration

Indexed keywords

DRUG DELIVERY; NANOSCOPIC DRUG CARRIERS; ROUTES OF ADMINISTRATION;

CONTROLLED DRUG DELIVERY; MACROMOLECULES; NANOSTRUCTURED MATERIALS;

DENDRIMERS;

2,2 BISHYDROXYMETHYLPROPIONIC ACID; ANTINEOPLASTIC AGENT; ARTEMETHER; BETAMETHASONE VALERATE; CHONDROITIN 4 SULFATE; DENDRIMER; DRUG CARRIER; FLURBIPROFEN; GALACTOSE; HYDRAZONE DERIVATIVE; INDOMETACIN; LAURIC ACID; LYSINE; MACROGOL; MELAMINE; MESALAZINE; PENICILLIN V; PHOSPHOLIPID; PILOCARPINE; POLYAMIDOAMINE; POLYESTER; POLYETHYLENE GLYCOL 5000 MONOMETHYL ETHER; POLYHYDROXYALKANOIC ACID; POLYMER; POLYPROPYLENEIMINE; PROPRANOLOL; SALAZOSULFAPYRIDINE; TAMSULOSIN; TROPICAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CONTROLLED DRUG RELEASE; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; MACROMOLECULE; NONHUMAN; REVIEW; SUSTAINED DRUG RELEASE;

ANIMALS; DENDRIMERS; DRUG CARRIERS; HUMANS; IMINES; NANOSTRUCTURES; POLYPROPYLENES;

EID: 33745457665     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2006.04.002     Document Type: Review

References (60)

1. Heller J. Use of polymers in controlled release of active agents. In: Robinson J.R., and Lee V.H.L. (Eds). Controlled drug delivery fundamentals and applications. 2nd ed (1987), Marcel Dekker, New York 179-212
2. Takenaga M. Application of lipid microsphere for treatment of cancer. Adv Drug Del Rev 20 (1996) 209-219
3. Duchene D., Ponchel G., and Wouessidjewe D. Cyclodextrins in targeting: application to nanoparticle. Adv Drug Del Rev 36 (1999) 29-40
4. Lu Y., and Chen S.C. Micro and nano fabrication of biodegradable polymers for drug delivery. Adv Drug Del Rev 56 (2004) 1621-1633
5. Tomalia D.A., Baker H., Dewald J., Hall M., Kallos G., Martin S., et al. A new class of polymers: starburst-dendritic macromolecules. Polym J 17 (1985) 117-132
6. Tomalia D.A., Naylor A.M., and Goddard III W.A. Starburst dendrimers: molecular level control of size, shape, surface chemistry topology and flexibility from atoms to macroscopic matter. Angew Chem Int Ed Engl 29 (1990) 138-175
7. Baars M.W.P.L., Kleppinger R., Koch M.H.J., Yeu S.L., and Meijer E.W. The localization of guests in water soluble oligoethyleneoxy modified poly(propylene imine) dendrimers. Angew Chem Int Ed 39 (2000) 1285-1288
8. Stevelmens S., Hest J.C.M., Jansen J.F.G.A., Boxtel D.A.F.J., de Bravander-van den B., and Miejer E.W. Synthesis, characterization and guest-host properties of inverted unimolecular micelles. J Am Chem Soc 118 (1996) 7398-7399
9. El-Sayed M., Rhodes C.A., Ginski M., and Ghandehari H. Transport mechanism (s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers. Int J Pharm 265 (2003) 151-157
10. Tajarobi F., El-Sayed M., Rege B.D., Polli J.E., and Ghandehari H. Transport of polyamido amine dendrimers across Madin-Darby canine kidney cells. Int J Pharm 215 (2001) 263-267
11. Jevprasesphant R., Penny J., Attwood D., and D'Emanuele A. Transport of dendrimer through epithelial cells via the transcellular route. J Control Release 97 (2004) 259-267
12. Haensler J., and Szoka Jr. F.C. Polyamidoamine cacade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4 (1993) 372-379
13. Tang M.X., Redemann C.T., and Szoka Jr. F.C. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 7 (1996) 703-714
14. Schatzlein A.G., Zinselmeyer B.H., Elouzi A., Dufes C., Chim Y.T.A., Roberts C.J., et al. Preferential liver gene expression with polypropylene imine dendrimers. J Control Release 101 (2005) 247-258
15. Bielinska A., Kukowska-Latallo J.F., Johnson J., Tomalia D.A., and Baker Jr. J. Regulation of in vitro gene expression using antisense oligonucleotide or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res 24 (1996) 2176-2182
16. Kukowska-Latallo J.F., Bielinska A.U., Johnson J., Spindler R., Tomalia D.A., and Baker Jr. J. Efficient transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers. Proc Natl Acad Sci U S A 93 (1996) 4897-4902
17. Kihara F., Arima H., Tsutsumi T., Hirayama F., and Uekama K. In vitro and in vivo gene transfer by optimised α-cyclodextrin conjugate with polyamido amine dendrimer. Bioconjug Chem 14 (2003) 342-350
18. Lim Y.B., Kim T., Lee J.W., Kim S.M., Kim H.J., Kim K., et al. Self-assembley ternary complex of cationic dendrimer, Cucurbituril and DNA. Non-covalent strategy in developing a gene delivery. Bioconjug Chem 13 (2002) 1181-1185
19. Wiener E.C., Brechbiel M.W., Brothers H., Magin R.L., Gansow O.A., Tomalia D.A., et al. Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents. Magn Reson Med 31 (1994) 1-8
20. Konda S.D., Aref M., Wang S., Brechbiel M., and Wiener E.C. Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. Magn Reson Mater Phys Biol Med 12 (2001) 104-113
21. Wu C., Brechbiel M.W., Kozak R.W., and Gansow O.A. Metal-chelate-dendrimer-antibody-constructs for use in radioimmunotherapy and imaging. Bioorg Med Chem Lett 4 (1994) 449-454
22. Milhem O.M., Myles C., McKeown N.B., Attwood D., and D'Emanuele A. Polyamidoamine Starburst dendrimers as solubility enhancers. Int J Pharm 197 (2000) 239-241
23. Hawker C.J., Wooley K.L., and Frechet J.M.J. Unimolecular micelles and globular amphiphiles: dendritic macromolecules as novel recyclable solubilization agents. J Chem Soc Perkin Trans 1 (1993) 1287-1297
24. Devarakonda B., Hill R.A., and De Villiers M.M. The effect of PAMAM dendrimer generation size and surface functional groups on the aqueous solubility of nifedipine. Int J Pharm 284 (2004) 133-140
25. Asthana A., Chauhan A.S., Diwan P.V., and Jain N.K. Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient. AAPS Pharm Sci Tech 27 (2005) 536-542
26. Ooya T., Lee J., and Park K. Effects of ethylene glycol-based grafts, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel. J Control Release 93 (2003) 121-127
27. Devarakonda B., Hill R.A., Liebenberg W., Brits M., and De Villiers M.M. Comparision of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins. Int J Pharm 300 (2005) 193-209
28. Bhadra D., Bhadra S., and Jain N.K. Pegylated lysine based copolymeric dendritic micelles for solubilization and drug delivery of artemether. J Pharm Pharm Sci 8 (2005) 467-482
29. Neofotistou E., and Demadis K.D. Use of antiscalants for mitigation of silica (SiO2) fouling and deposition: fundamentals and application in desalination system. Desalination 167 (2004) 257-272
30. Aulenta F., Hayes W., and Rannard S. Dendrimers: a new class of nanoscopic containers and delivery devices. Eur Polym J 39 (2003) 1741-1771
31. Bosman A.W., Janssen H.M., and Meijer E.W. About dendrimers: structure, physical properties and applications. Chem Rev 99 (1999) 1665-1688
32. Esfand R., and Tomalia D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today 6 (2001) 427-436
33. Patri A.K., Majoros I.J., and Baker Jr. J.R. Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol 6 (2002) 466-471
34. Cloninger M.J. Biological applications of dendrimers. Curr Opin Chem Biol 6 (2002) 742-748
35. Gillies E.R., and Frechet J.M.J. Dendimers and dendritic polymer in drug delivery. Drug Discov Today 10 (2005) 35-43
36. Patri A.K., Kukowska-Latallo J.F., and Baker Jr. J.R. Transdermal drug delivery with dendrimers: comparison of the release kinetics of the covalently conjugated drug and non covalent drug inclusion complex. Adv Drug Del Rev 57 (2005) 2203-2214
37. Bhadra D., Bhadra S., Jain S., and Jain N.K. A PEGylated dendritic nanoparticulate carrier of fluorouracil. Int J Pharm 257 (2003) 111-124
38. Bhadra D., Bhadra S., and Jain N.K. PEGylated peptide based dendritic nanoparticulate systems for delivery of artemether. J Drug Del Sci Tech 15 (2005) 65-73
39. Bhadra D., Yadav A.K., Bhadra S., and Jain N.K. Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting. Int J Pharm 295 (2005) 221-233
40. Padilla De Jesus O.L., Ihre H.R., Gague L., Frechet J.M.J., and Szoka Jr. F.C. Polyester dendritic systems for drug delivery applications in vitro and in vivo evaluation. Bioconjug Chem 13 (2002) 453-461
41. Ihre H.R., Padilla De Jesus O.L., Szoka Jr. F.C., and Frechet J.M.J. Polyester dendrimer systems for drug delivery applications design, synthesis and characterization. Bioconjug Chem 13 (2002) 443-452
42. Neerman M.F., Zhang W., Parrish A.R., and Simanek E.E. In vivo and in vitro evaluation of a melamine dendrimer as a vehicle for drug delivery. Int J Pharm 281 (2004) 129-132
43. Zhang W., Jiang J., Qin C., Thomson L.M., Parrish A.R., Safe S.H., et al. Triazine dendrimers for drug delivery: evaluations of solubilization properties activity in cell culture and in vivo toxicity of a candidate vehicle. Supramol Chem 15 (2003) 607-615
44. Chen H.T., Neerman M.F., Parrish A.R., and Simanek E.E. Cytotoxicity haemolysis and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery. J Am Chem Soc 126 (2004) 10044-10048
45. Wang Z., Itoh Y., Hosaka Y., Kobayashi I., Nakamo Y., Maeda I., et al. Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamido amine dendrimers. J Biosci Bioeng 95 (2003) 541-543
46. Wang Z., Iton Y., Hosaka Y., Kobayashi I., Nakano Y., Maeda I., et al. Mechanism of enhancement effect of dendrimer on transdermal drug permeation through poly hydroxy alkanoate matrix. J Biosci Bioeng 96 (2003) 537-540
47. Chauhan A.S., Sridevi S., Chalasani K.B., Jain A.K., Jain S.K., Jain N.K., et al. Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin. J Control Release 90 (2003) 335-343
48. Vandamme T.F., and Brobeck L. Polyaminido amine dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release 102 (2005) 23-38
49. Wiwattanapatapee R., Correno-Gomez B., Malik N., and Duncan R. Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system. Pharm Res 17 (2000) 991-998
50. Florence A.T., Sakthivel T., and Toth I. Oral uptake and translocation of poly lysine dendrimer with a lipid surface. J Control Release 65 (2000) 253-259
51. Tripathi P.R., Khopade A.J., Nagaich S., Shrivastava S., Jain S., and Jain N.K. Dendrimer grafts for delivery of 5-fluorouracil. Pharmazie 57 (2002) 261-264
52. D'Emanuele A., Jevprasesphant J.P., Penny J., and Attwood D. The use of a dendrimer propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release 95 (2004) 447-453
53. Yang L., Chu J.S., and Fix J.A. Colon specific drug delivery: new approaches and in vitro/in vivo evaluation. Int J Pharm 235 (2002) 1-15
54. Kopecek J., Kopeckova P., Brondsted H., Rathi R., Rihova B., Yeh P.Y., et al. Polymers for colon specific drug delivery. J Control Release 19 (1992) 121-130
55. Sinha V.R., and Kumaria R. Colonic drug delivery: prodrug approach. Pharm Res 18 (2001) 557-564
56. Wiwattanapatapee R., Lomlim L., and Saramunce K. Dendrimers conjugates for colonic delivery of 5-amino salicylic acid. J Control Release 88 (2003) 1-9
57. Quintana A., Raczka E., Piehler L., Lee I., Myc A., Majoros I., et al. Design and function of a dendrimer based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res 19 (2002) 1310-1316
58. Yang M., and Lopina S.T. Penicillin V-conjugated PEG-PAMAM star polymers. J Biomater Sci Polym Ed 14 (2003) 1043-1056
59. Sideratou Z., Tsiourvas D., and Paleos C.M. Solubilization and release properties of PEGylated diaminobutane polypropyleneimine dendrimers. J Colloid Interface Sci 242 (2001) 272-276
60. Kojima C., Kono K., Maruyama K., and Takagishi T. Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjug Chem 11 (2000) 910-917