Somatostatin and its analogues in peptic ulcer bleeding: Facts and pathophysiological aspects

Digestive and Liver Disease

Volumn 38, Issue 2, 2006, Pages 143-148

  Sgouros, S N ^a   Bergele, C ^b   Viazis, N ^b   Avgerinos, A ^b  

^a ATHENS NAVAL HOSPITAL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Acid inhibition; Lanreotide; Octreotide; Peptic ulcer bleeding; Somatostatin; Vapreotide

Indexed keywords

ACID; CIMETIDINE; GASTRIN; HISTAMINE H2 RECEPTOR ANTAGONIST; OCTREOTIDE; OMEPRAZOLE; PANTOPRAZOLE; PEPSIN A; PLACEBO; PROTON PUMP INHIBITOR; RANITIDINE; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 1; STOMACH SECRETION INHIBITOR; DRUG DERIVATIVE; GASTROINTESTINAL AGENT; HORMONE;

ARTICLE; BLOOD CLOT; CLINICAL TRIAL; DRUG EFFICACY; DRUG MECHANISM; ENDOSCOPY; GASTRIN RELEASE; GASTROINTESTINAL MUCOSA; HEMODYNAMICS; HIGH RISK PATIENT; HUMAN; INTESTINE BLOOD FLOW; MORTALITY; PATHOPHYSIOLOGY; PEPSIN SECRETION; PEPTIC ULCER BLEEDING; PROTEIN DEGRADATION; STOMACH ACID SECRETION; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; RANDOMIZED CONTROLLED TRIAL; REVIEW; SPLANCHNIC BLOOD FLOW;

GASTROINTESTINAL AGENTS; HORMONES; HUMANS; OCTREOTIDE; PEPTIC ULCER HEMORRHAGE; RANDOMIZED CONTROLLED TRIALS; SOMATOSTATIN; SPLANCHNIC CIRCULATION;

EID: 33745426057     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2005.05.009     Document Type: Article

References (50)

1. Laine L., and Peterson W.L. Bleeding peptic ulcer. N Engl J Med 331 (1994) 717-727
2. Barkun A., Sandrine S., Enns R., Armstrong D., Gregor J., Fedorak R.N., et al. The Canadian registry of nonvariceal upper gastrointestinal bleeding and endoscopy (RUGBE): endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real - life setting. Am J Gastroenterol 99 (2004) 1238-1246
3. Green Jr. F.W., Kaplan M.M., Curtis L.E., and Levine P.H. Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor to prolonged gastroduodenal mucosal hemorrhage. Gastroenterology 74 (1978) 38-43
4. Vreeburg E.M., Levi M., Rauws E.A.J., Deventer S.J., Snel P., Bartelsman J.W., et al. Enhanced mucosal fibrinolytic activity in gastroduodenal ulcer haemorrhage and the beneficial effect of acid suppression. Aliment Pharmacol Ther 15 (2001) 639-646
5. Chalmhoff C., Creter D., and Djaldetti M. The effect of pH on platelet and coagulation factor activities. Am J Surg 136 (1978) 257-259
6. Patchett S.E., Enright H., Afdhal N., O'Connell W., and O'Donoghue D.P. Clot lysis by gastric juice: an in vivo study. Gut 30 (1989) 1704-1707
7. Patchett S.E., and O'Donoghue D.P.O. Pharmacological manipulation of gastric juice: thrombelastographic assessment and implications for treatment of gastrointestinal haemorrhage. Gut 36 (1995) 358-362
8. Khuroo M.S., Yattoo G.N., Javid G., Khan B.A., Shah A.A., Gulzar G.M., et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 336 (1997) 1054-1058
9. Schaffalitzky de Muckadell O.B., Havelund T., Harling H., Boesby S., Snel P., Vreeburg E.M., et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers: a randomized double-blind placebo-controlled multicenter study. Scand J Gastroenterol 32 (1997) 320-327
10. Barkun A.N., Cockeram A.W., Plourde V., and Fedorak R.N. Review article: acid suppression in non-variceal acute upper gastrointestinal bleeding. Aliment Pharmacol Ther 13 (1999) 1565-1584
11. Zed P.J., Loewen P.S., Slavik R.S., and Marra C.A. Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother 35 (2001) 1528-1534
12. Walt R.P., Cotterell J., Mann S.G., Freemantle N.P., and Langman M.J.S. Continuous intravenous famotidine for haemorrhage from peptic ulcer. Lancet 340 (1992) 1058-1062
13. Labenz J., Peitz U., Leusing C., Tillenburg B., Blum A.L., and Borsch G. Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomized controlled study. Gut 40 (1997) 36-41
14. Lau J.Y.W., Sung J.J.Y., Lee K.K.C., Yung M.Y., Wong S.K., Wu J.C., et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 343 (2000) 310-316
15. van Rensburg C.J., Hartmann M., Thorpe A., Venter L., Theron I., Luhmann R., et al. Intragastric pH during continuous infusion with pantoprazole in patients with peptic ulcer bleeding. Am J Gastroenterol 98 (2003) 2635-2641
16. Jensen D.M., Kovacs T.O.G., Jutabha R., Machicado G.A., Gralnek I.M., Savides T.J., et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology 123 (2002) 407-413
17. Sung J.J.W., Chan F.K.L., Lau J.Y.W., Yung M.Y., Leung W.K., Wu J.C., et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots. A randomized comparison. Ann Intern Med 139 (2003) 237-243
18. Sonnenberg G.E., Keller U., Perruchoud A., Burckhardt D., and Gyr K. Effect of somatostatin on splachnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology 80 (1981) 526-532
19. Bosch J., Kravetz D., and Rodes J. Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: comparison with vasopressin. Gastroenterology 80 (1981) 518-525
20. Villanueva C., Ortiz J., Minana J., Soriano G., Sabat M., Boadas J., et al. Somatostatin treatment and risk stratification by continuous portal pressure monitoring during acute variceal bleeding. Gastroenterology 121 (2001) 110-117
21. Avgerinos A., Nevens F., Raptis S., and Fevery J. Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Lancet 350 (1997) 1495-1499
22. D'Amico G., Pietrosi G., Tarantino I., and Pagliaro L. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis. Gastroenterology 124 (2003) 1277-1291
23. Mottet C., Sieber C.C., Nauer A., Drewe J., Fried R., Larsen F., et al. Haemodynamic effects of the somatostatin analog lanreotide in humans; placebo controlled, cross over, dose ranging Echo Doppler study. Hepatology 27 (1998) 920-925
24. Kubba A.K., Dallal H., Haydon G.H., Hayes P.C., and Palmer K.R. The effect of octreotide on gastroduodenal blood flow measured by laser Doppler flowmetry in rabbits and man. Am J Gastroenterol 94 (1999) 1077-1082
25. Lunde O.C., Kvernebo K., Hanssen L.E., and Larsen S. Effect of somatostatin on human gastric blood flow evaluated by endoscopic laser Doppler flowmetry. Scand J Gastroenterol 22 (1987) 842-846
26. Saruc M., Can M., Kucukmentin N., Tuzcuoglu I., Tarhan S., Goktan C., et al. Somatostatin infusion and hemodynamic changes in patients with non-variceal upper gastrointestinal bleeding; a pilot study. Med Sci Monit 9 (2003) 184-187
27. Samloff I.M. Peptic ulcer: the many proteinases of aggression. Gastroenterology 96 (1989) 586-595
28. Schubert M.L. Regulation of gastric acid secretion. Curr Opin Gastroenterol 14 (1998) 425-434
29. Sandvic A.K., and Waldrum H.L. The effects of somatostatin on baseline and stimulated acid secretion and vascular histamine release from the totally isolated vascularly perfused rat stomach. Regul Pept 20 (1988) 233-239
30. Mogard M.H., Maxwell V., and Kovacs T. Somatostatin inhibits gastric acid secretion after gastric mucosal prostaglandin synthesis inhibition by indomethacin in man. Gut 26 (1988) 1189-1191
31. Raptis S., Dollinger H.C., Berger L.V., Schlegel W., Schroder K.E., and Pfeiffer E.F. Effects of somatostatin on gastric secretion and gastrin release in man. Digestion 13 (1975) 15-26
32. Creutzfeldt W., and Arnold R. Somatostatin and the stomach: exocrine and endocrine aspects. Metabolism 27 Suppl. 1 (1978) 1309-1315
33. Bloom S.R., Mortimer C.H., Thorner M.O., Besser G.M., Hall R., Gomez-Pan A., et al. Inhibition of gastrin and gastric acid secretion by growth-hormone release-inhibiting hormone. Lancet 2 (1974) 1106-1109
34. Johansson C., and Aly A. Stimulation of gastric mucus output by somatostatin in man. Eur J Clin Invest 12 (1982) 37-39
35. Avgerinos A., Sgouros S., Viazis N., Vlachogiannakos J., Papaxoinis K., Bergele C., et al. Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: a prospective, randomised, placebo-controlled trial. Scand J Gastroenterol 40 (2005) 515-522
36. Walker V., and Taylor W.H. Pepsin 1 secretion in chronic peptic ulceration. Gut 21 (1980) 776-781
37. Pearson J.P., Ward R., Allen A., Roberts N.B., and Taylor W.H. Mucus degradation by pepsin 1: comparison of mucolytic activity of human pepsin 1and pepsin 3: implications in peptic ulceration. Gut 27 (1986) 243-248
38. Tulassay Z., Gupta R., Papp J., and Bodnar A. Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: a prospective, randomized, controlled trial. Am J Gastroenterol 84 (1989) 6-9
39. Coraggio F., Bertini G., Catalano A., Scarpato P., and Gualdieri L. Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract. Digestion 43 (1989) 190-195
40. Coraggio F., Rotondano G., Marmo R., Balzanelli M.G., Catalano A., Clemente F., et al. Somatostatin in the prevention of recurrent bleeding after endoscopic haemostasis of peptic ulcer haemorrhage: a preliminary report. Eur J Gastroenterol Hepatol 10 (1998) 673-676
41. Okan A., Simsek I., Akpinar H., Ellidokuz E., Sanul A.R., and Aksoz K. Somatostatin and ranitidine in the treatment of non-variceal upper gastrointestinal bleeding: a prospective, randomised, double-blind, controlled study. Hepatogastroenterology 47 (2000) 1325-1327
42. Christiansen J., Ottenjann R., and Von Arx F. Placebo-controlled trial with the somatostatin analogue SMS 201-995 in peptic ulcer bleeding. Gastroenterology 97 (1989) 568-574
43. Lin H.J., Perng C.L., Wang K., Lee C.H., and Lee S.D. Octreotide for arrest of peptic ulcer hemorrhage-a prospective, randomized controlled trial. Hepatogastroenterology 42 (1995) 856-860
44. Lin H.J., Wang K., Perng C.L., Chua R.T., Lee C.H., and Lee S.D. Octreotide and heater probe thermocoagulation for arrest of peptic ulcer haemorrhage: a prospective, randomised, controlled trial. J Clin Gastroenterol 21 (1995) 95-98
45. Imperiale T.F., and Birgisson S. Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal haemorrhage. A metaanalysis. Ann Intern Med 127 (1997) 1062-1071
46. Patel Y.C., Greenwood M.T., Warszynska A., Panetta R., and Srikant C.B. All five cloned human somatostatin receptors (hSSTR 1-5) are functionally coupled to adenylate cyclase. Biochem Biophys Res Commun 198 (1994) 605-612
47. Patel Y.C., and Srikant C.B. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hSSTR 1-5). Endocrinology 135 (1994) 2814-2817
48. Hoyer D., Bell G.I., Berelowitz M., Epelbaum J., Feniuk W., Humphrey P.P., et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 16 (1995) 86-88
49. Avgerinos A., Viazis N., Vlachogiannakos J., Poulianos G., Armonis A., Manolakopoulos S., et al. Two different dose and duration schedules of somatostatin-14 in the treatment of patients with bleeding oesophageal varices. A nonrandomised controlled study. J Hepatol 32 (2000) 171-172
50. Mointinho E., Planas R., Bañares R., Albillos A., Ruiz-del-Arbol L., Gálvez C., et al., Variceal Bleeding Study Group. Multicenter randomized controlled trial comparing different schedules of treatment of somatostatin in the treatment of acute variceal bleeding. J Hepatol 35 (2001) 712-718