Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: A prospective, randomized, placebo-controlled trial

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 5, 2005, Pages 515-522

  Avgerinos, Alec ^a,b   Sgouros, Spiros ^a   Viazis, Nikos ^a   Vlachogiannakos, John ^a   Papaxoinis, Kostis ^a   Bergele, Christina ^a   Sklavos, Pantelis ^a   Raptis, Sotiris A ^b  

^a EVANGELISMOS HOSPITAL   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Gastric acid inhibition; Pantoprazole; Peptic ulcer bleeding; Somatostatin

Indexed keywords

ANTIVITAMIN K; HISTAMINE H2 RECEPTOR ANTAGONIST; LOW MOLECULAR WEIGHT HEPARIN; OMEPRAZOLE; PANTOPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR; SODIUM CHLORIDE; SOMATOSTATIN; STOMACH SECRETION INHIBITOR; VASOACTIVE AGENT;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HEADACHE; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH ACID SECRETION; STOMACH FUNDUS; STOMACH PH;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANTI-ULCER AGENTS; BENZIMIDAZOLES; DOUBLE-BLIND METHOD; FEMALE; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; H(+)-K(+)-EXCHANGING ATPASE; HORMONES; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; OMEPRAZOLE; PEPTIC ULCER HEMORRHAGE; PROSPECTIVE STUDIES; SOMATOSTATIN; SULFOXIDES;

EID: 18744362748     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520510015458     Document Type: Article

References (33)

1. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med 1994;331:717-27.
2. Barkum A, Sandrine S, Enns R, Armstrong D, Gregor J, Fedorak RNN, et al., and the RUGBE Investigators. The Canadian registry of nonvariceal upper gastrointestinal bleeding and endoscopy (RUGBE): endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting. Am J Gastroenterol 2004;99: 1238-46.
3. Green FW Jr, Kaplan MM, Curtis LE, Levine PH. Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor to prolonged gastroduodenal mucosal hemorrhage. Gastroenterology 1978;74:38-43.
4. Vreeburg EM, Levi M, Rauws EAJ, Devender SJHV, Snel P, Bartelsman JWFM, et al. Enhanced mucosal fibrinolytic activity in gastroduodenal ulcer haemorrhage and the beneficial effect of acid suppression. Aliment Pharmacol Ther 2001;15:639-46.
5. Chalmhoff C, Creter D, Djaldetti M. The effect of pH on platelet and coagulation factor activities. Am J Surg 1978; 136:257-9.
6. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP. Clot lysis by gastric juice: an in vivo study. Gut 1989;30:1704-7.
7. Patchett SE, O'Donoghue DPO. Pharmacological manipulation of gastric juice: thromboelastographic assessment and implications for treatment of gastrointestinal haemorrhage. Gut 1995;36:358-62.
8. Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, Gulzar GM, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 1997;336:1054-8.
9. Schaffalitzky de Muckadell OB, Havelund T, Harling H, Boesby S, Snel P, Vreeburg EM, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers: a randomized double-blind placebo-controlled multicenter study. Scand J Gastroenterol 1997;32:320-7.
10. Barkun AN, Cockeram AW, Plourde V, Fedorak RN. Acid suppression in non-variceal acute upper gastrointestinal bleeding [review article]. Aliment Pharmacol Ther 1999; 13:1565-84.
11. Zed PJ, Loewen PS, Slavik RS, Marra CA. Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother 2001;35:1528-34.
12. Walt RP, Cotterell J, Mann SG, Freemantle NP, Langman MJS. Continuous intravenous famotidine for haemorrhage from peptic ulcer. Lancet 1992;340:1058-62.
13. Labenz J, Peitz U, Leusing C, Tillenburg B, Blum AL, Borsch G. Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomized controlled study. Gut 1997;40:36-41.
14. Lau JYW, Sung JJY, Lee KKC, Yung M-Y, Wong SKH, Wu JCY, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 2000;343:310-6.
15. Jensen DM, Kovacs TOG, Jutabha R, Machicado GA, Gralnek IM, Savides TI, et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology 2002;123: 407-13.
16. Sung JJW, Chan FKL, Lau JYW, Yung M-Y, Leung WK, Wu JC, et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots. A randomized comparison. Ann Intern Med 2003;139:237-43.
17. Sonnenberg GE, Keller U, Perruchoud A, Burckhardt D, Gyr K. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology 1981;80:526-32.
18. Saruc M, Can M, Kucukmetin N, Tuzuoglu I, Tarhan S, Goktan C, et al. Somatostatin infusion and hemodynamic changes in patients with non-variceal upper gastrointestinal bleeding: a pilot study. Med Sci Monit 2003;9:184-7.
19. Avgerinos A, Nevens F, Raptis S, Fevery J, and the ABOVE Study Group. Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: The European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomized trial, Lancet 1997;350: 1495-9.
20. Avgerinos A. A role for somatostatin in upper gastrointestinal bleeding. Digestion 1998;59(Suppl 1):1-22.
21. Avgerinos A, Viazis N, Vlachogiannakos J, Poulianos G, Armonis A, Manolakopoulos S, et al. Two different dose and duration schedules of somatostatin-14 in the treatment of patients with bleeding oesophageal varices. A non randomised controlled study. J Hepatology 2000;32:171-2.
22. Mointinho E, Planas R, Banares R, Albillos A, Ruiz-Del-Arbol L, Calvez C, et al. Variceal Bleeding Study Group. Multicenter randomized controlled trial comparing different schedules of treatment of somatostatin in the treatment of acute variceal bleeding. J Hepatology 2001;35:712-8.
23. Avgerinos A, Vlachogiannakos J, Viazis N, Raptis S. Clearing the stomach before emergency endoscopy in cirrhotics with acute upper gastrointestinal bleeding: a gastrokinetic or a vasoactive drug? J Hepatology 2003;39:130-1.
24. D'Amico G, Pietrosi G, Tarantino I, Pagliaro L. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis. Gastroenterology 2003; 124:1277-91.
25. Forrest JAH, Finlayson NDC, Shearman DCJ. Endoscopy of upper gastrointestinal bleeding. Lancet 1974;2:394-7.
26. Fackler WK, Vaezi MF, Richter JE. Ambulatory gastric pH monitoring: proper probe placement and normal values. Aliment Pharmacol Ther 2001;15:1155-62.
27. Berstad A, Holm HA, Kittang E. Experience with antipeptic agents. Scand J Gastroenterol 1979;14(Suppl 55):121-3.
28. Berstad A. Does profound acid inhibition improve haemostasis in peptic ulcer bleeding? Scand J Gastroenterol 1997; 32:396-8.
29. Kaviani MJ, Hashemi MR, Kazemifar AR, Rootzitalab S, Mostaghni AA, Merat S, et al. Effect of oral omeprazole in reducing re-bleeding in bleeding peptic ulcers: a prospective, double-blind, randomized, clinical trial. Aliment Pharmacol Ther 2003;17:211-6.
30. Shih GL, Brensinger C, Katzka DA, Metz DC. Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring. Am J Gastroenterol 2003;98:1713-8.
31. Gralnek IM, Jensen DM, Gornbein J, Kovacs TOG, Jutabha R, Freeman ML, et al. Clinical and economic outcomes of individuals with severe peptic ulcer haemorrhage and a nonbleeding visible vessel: an analysis of two prospective clinical trials. Am J Gastroenterol 1998;93:2047-56.
32. 2 antagonists and placebo in the management of acute non-variceal upper gastrointestinal haemorrhage: a meta-analysis. Ann Intern Med 1997;127:1062-71.
33. Raptis S, Dollinger HC, von Berger L, Schlegel W, Schroder KE, Pfeifer EF. Effects of somatostatin on gastric secretion and gastrin release in man. Digestion 1975;13:15-26.