Coupling of C3bi to IgG inhibits the tyrosine phosphorylation signaling cascade downstream Syk and reduces cytokine induction in monocytes

Journal of Leukocyte Biology

Volumn 79, Issue 5, 2006, Pages 1073-1082

  Trinidad, Antonio García ^a   De La Puerta, María Luisa ^a   Fernández, Nieves ^a   Bayón, Yolanda ^a   Crespo, Mariano Sánchez ^a,b   Alonso, Andrés ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

Author keywords

Fc receptors; Phagocytosis

Indexed keywords

COMPLEMENT FACTOR I; CYTOKINE; EOTAXIN; FC RECEPTOR; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PHOSPHOLIPASE C GAMMA1; PHOSPHOLIPASE C GAMMA2; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; PROTEIN KINASE SYK; TUMOR NECROSIS FACTOR ALPHA; TYROSINE; ZYMOSAN; BETA GLUCAN; COMPLEMENT COMPONENT C3B; ONCOPROTEIN; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; CELL LINE; DOWN REGULATION; DRUG EFFECT; FEEDBACK SYSTEM; IMMUNOLOGY; MACROMOLECULE; METABOLISM; PHAGOCYTOSIS; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

FUNGI;

BETA-GLUCANS; CELL LINE; COMPLEMENT C3B; CYTOKINES; DOWN-REGULATION; FEEDBACK, BIOCHEMICAL; HUMANS; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROMOLECULAR SUBSTANCES; MAP KINASE SIGNALING SYSTEM; MONOCYTES; ONCOGENE PROTEIN V-AKT; PHAGOCYTOSIS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TYROSINE; ZYMOSAN;

EID: 33745298116     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1205701     Document Type: Article

References (40)

1. Stuart, L. M., Ezekowitz, M. R. A. (2005) Phagocytosis: elegant complexity. Immunity 22, 539-550.
2. Janeway Jr., C. A., Medzhitov, R. (2002) Innate immune recognition. Annu. Rev. Immunol. 20, 197-216.
3. Medzhitov, R., Janeway Jr., C. A. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298.
4. Thornton, B. P., Vetvicka, V., Pitman, M., Goldman, R. C., Ross, G. D. (1996) Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J. Immunol. 156, 1235-1246.
5. Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martínez-Pomares, L., Wong, S. Y., Gordon, S. (2002) Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196, 407-412.
6. Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., Underhill, D. M. (2003) Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197, 1107-1117.
7. Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S., Gordon, S. (2003) Dectin-1 mediates the biological effects of β-glucans. J. Exp. Med. 197, 1119-1124.
8. Sylvestre, D. L., Ravetch, J. V. (1994) Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science 265, 1095-1098.
9. Hazenbos, W. L., Gessner, J. E., Hofhuis, F. M., Kuipers, H., Meyer, D., Heijnen, I. A., Schmidt, R. E., Sandor, N., Capel, P. J., Daeron, M., van den Winkel, J. G., Verbeek, J. S. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16)-deficient mice. Immunity 5, 181-188.
10. Ehlers, M. R. W. (2000) CR3: a general purpose adhesion-recognition receptor essential for innate immunity. Microbes Infect 2, 289-294.
11. Gerard, N. P., Gerard, C. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614-617.
12. Fernández, N., Renedo, M. A., Alonso, S., Sánchez Crespo, M. (2003) Release of arachidonic acid by stimulation of opsonic receptors in human monocytes: the FcγR and the complement receptor 3 pathways. J. Biol. Chem. 278, 52179-52187.
13. Turner, M., Schweighoffer, E., Colucci, F., Di Santo, J. P., Tybulewicz, V. L. (2000) Tyrosine kinase SYK: essential functions for immunoreceptor signaling. Immunol. Today 21, 148-153.
14. Lin, T. H., Rosales, C., Mondal, K., Bolen, J. B., Haskill, S., Juliano, R. L. (1995) Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. J. Biol. Chem. 270, 16189-16197.
15. Gu, H., Botelho, R. J., Yu, M., Grinstein, S., Neel, B. G. (2003) Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis. J. Cell Biol. 161, 1151-1161.
16. Ganesan, L. P., Wei, G., Pengal, R. A., Moldovan, L., Moldovan, N., Ostrowski, M. C., Tridandapani, S. (2004) The serine/threonine kinase Akt promotes Fcγ receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J. Biol. Chem. 279, 54416-54425.
17. Song, X., Tanaka, S., Cox, D., Lee, S. C. (2004) FcγR signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. J. Leukoc. Biol. 75, 1147-1155.
18. Vivanco, F., Muñoz, E., Vidarte, L., Pastor, C. (1999) The covalent interaction of C3 with IgG immune complexes. Mol. Immunol. 36, 843-852.
19. Zhao, T., Benard, V., Bohl, B. P., Bokoch, G. M. (2003) The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J. Clin. Invest. 112, 1732-1740.
20. Mustelin, T., Vang, T., Bottini, N. (2005) Protein tyrosine phosphatases and the immune response. Nat. Rev. Immunol. 5, 43-57.
21. Herre, J., Marshall, A. S., Caron, E., Edwards, A. D., Williams, D. L., Schweighoffer, E., Tybulewicz, V., Reis e Sousa, C., Gordon, S., Brown, G. D. (2004) Dectin-1 utilizes novel mechanisms for yeast phagocytosis in macrophages. Blood 104, 4038-4045.
22. Astarie-Dequeker, C., N'Diaye, E. N., Le Cabec, V., Rittig, M. G., Prandi, J., Maridonneau-Parini, I. (1999) The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages. Infect. Immun. 67, 469-477.
23. Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, A. L., Gordon, S., Tybulewicz, V. L., Brown, G. D., Reis e Sousa, C. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C-type lectins. Immunity 22, 507-517.
24. Diamond, M. S., Garcia-Aguilar, J., Bickford, J. K., Corbi, A. L., Springer, T. A. (1993) The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 120, 1031-1043.
25. Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A., Wilson, C. B., Bassetti, M., Aderem, A. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811-815.
26. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., Kirschning, C. J. (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. J. Biol. Chem. 274, 17406-17409.
27. Dziarski, R., Gupta, D. (2005) Staphylococcus aureus peptidoglycan is a Toll-like receptor 2 activator: a reevaluation. Infect. Immun. 73, 5212-5216.
28. Allen, L. A., Aderem, A. (1996) Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J. Exp. Med. 184, 627-637.
29. 3. EMBO J. 16, 6414-6425.
30. Mocsai, A., Zhou, M., Meng, F., Tybulewicz, V. L., Lowell, C. A. (2002) Syk is required for integrin signaling in neutrophils. Immunity 16, 547-558.
31. Yan, S. R., Huang, M., Berton, G. (1997) Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. J. Immunol. 158, 1902-1910.
32. 2 integrins activate different signaling pathways in monocytes. Biochem. J. 363, 273-280.
33. 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-519.
34. Urzainqui, A., Serrador, J. M., Viedma, F., Yanez-Mo, M., Rodriguez, A., Corbi, A. L., Alonso-Lebrero, J. L., Luque, A., Deckert, M., Vazquez, J., Sanchez-Madrid, F. (2002) ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity 17, 401-412.
35. Jakus, Z., Berton, G., Ligeti, E., Lowell, C. A., Mocsai, A. (2004) Responses of neutrophils to anti-integrin antibodies depends on costimulation through low-affinity FcγRs: full activation requires both integrin and nonintegrin signals. J. Immunol. 173, 2068-2077.
36. Fernández, N., Renedo, M., García-Rodríguez, M. C., Sánchez Crespo, M. (2002) Activation of monocytic cells through Fcγ receptors induces the expression of macrophage-inflammatory protein (MIP)-1α, MIP-1β, and RANTES. J. Immunol. 169, 3321-3328.
37. Alonso, A., Bayon, Y., Renedo, M., Sánchez Crespo, M. (2000) Stimulation of FcγR receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving IκB-α degradation and formation of p50/p65 NF-κB/Rel complexes. Int. Immunol. 12, 547-554.
38. Basak, C., Pathak, S. K., Bhattacharyya, A., Mandal, D., Pathak, S., Kundu, M. (2004) NF-κB-and C/EBPβ-driven interleukin-1β gene expression and PAK1-mediated caspase 1 activation play essential roles in interleukin-1β release from Helicobacter pylori lipopolysaccharide (LPS)-stimulated macrophages. J. Biol. Chem. 280, 4279-4288.
39. Kitaura, J., Xiao, W., Maeda-Yamamoto, M., Kawakami, Y., Lowell, C. A., Kawakami, T. (2004) Early divergence of Fcε receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J. Immunol. 173, 4317-4323.
40. 2α reigns supreme in arthritis and bone resorption. Trends Immunol. 25, 116-119.