Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 318, Issue 1, 2006, Pages 411-417

  Das, Anuk M ^a   Vaddi, Krishna G ^a   Solomon, Kimberly A ^a   Krauthauser, Candice ^a   Jiang, Xiaosui ^a   McIntyre, Kim W ^a   Xiao, Xia Yang ^a   Wadman, Eric ^a   Welch, Patricia ^a   Covington, Maryanne ^a   Graden, Danielle ^a   Yeleswaram, Krishnaswamy ^a   Trzaskos, James M ^a   Newton, Robert C ^a   Mandlekar, Sandhya ^a   Ko, Soo S ^a   Carter, Percy H ^a   Davies, Paul ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR3; EOTAXIN; OVALBUMIN; SODIUM CHLORIDE;

AIRWAY; ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CHEMOTAXIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; EOSINOPHIL; EOSINOPHILIA; FEMALE; HELPER CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG; LUNG LAVAGE; MALE; MAST CELL; MAXIMUM ALLOWABLE CONCENTRATION; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; WILD TYPE;

ANIMALS; CELL MIGRATION INHIBITION; CHO CELLS; CRICETINAE; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; HUMANS; INFLAMMATION; LUNG; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE; RESPIRATORY HYPERSENSITIVITY;

EID: 33745268232     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.099812     Document Type: Article

References (39)

1. Berkman N, Ohnona S, Chung FK, and Breuer R (2001) Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. Am J Respir Cell Mol Biol 24:682-687.
2. Bochner BS (2004) Verdict in the case of therapies versus eosinophils: the jury is still out. J Allergy Clin Immunol 113:3-9.
3. Borchers MT, Ansay T, DeSalle R, Daugherty BL, Shen H, Metzger M, Lee NA, and Lee JJ (2002) In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J Leukoc Biol 71:1033-1041.
4. Brown JR, Kleimberg J, Marini M, Sun G, Bellini A, and Mattoli S (1998) Kinetics of eotaxin expression and its relationship to eosinophil accumulation and activation in bronchial biopsies and bronchoalveolar lavage (BAL) of asthmatic patients after allergen inhalation. Clin Exp Immunol 114:137-146.
5. Campbell EM, Kunkel SL, Strieter RM, and Lukacs NW (1998) Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J Immunol 161:7047-7053.
6. Das AM, Flower RJ, Hellewell PG, Teixeira MM, and Perretti M (1997a) A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. Br J Pharmacol 121:97-104.
7. Das AM, Flower RJ, and Perretti M (1997b) Eotaxin-induced eosinophil migration in the peritoneal cavity of albumin-sensitized mice: mechanism of action. J Immunol 159:1466-1473.
8. Das AM, Flower RJ, and Perretti M (1998) Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo. J Leukoc Biol 64:156-162.
9. Daugherty BL, Siciliano SJ, deMartino JA, Malkowitz L, Sirotina A, and Springer S (1996) Cloning, expression and characterization of the human eosinophil eotaxin receptor. J Exp Med 183:2349-2354.
10. DeLucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JBI, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, et al. (2005) Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem 48:2194-2211.
11. Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, and Baggiolini M (1997) Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3 and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 185:2171-2176.
12. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TNC, Proudfoot A, Martinez-A C, Dorf M, Bjerke T, Coyle AJ, et al. (1998) The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 188:157-167.
13. Grimaldi JC, Yu N-X, Grunig G, Seymour BWP, Cottrez F, Robinson DS, Hosken N, Ferlin WG, Wu X, Soto H, et al. (1999) Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3). J Leukoc Biol 65:846-853.
14. Harris RR, Komater VA, Maret RA, Wilcox DM, and Bell RL (1997) Effect of mast cell deficiency and leukotriene inhibition on the influx of eosinophils induced by eotaxin. J Leukoc Biol 62:688-691.
15. Harvath L, Falk W, and Leonard EJ (1980) Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multi-well assembly. J Immunol Methods 37:39-45.
16. Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, Martin TR, Gerard NP, and Gerard C (2002) The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation. Proc Natl Acad Sci USA 99:1479-1484.
17. Kay AB, Phipps S, and Robinson DS (2004) A role for eosinophils in airway remodeling in asthma. Trends Immunol 25:477-482.
18. Ko SS, Pruitt JR, Wacker DA, and Batt DG (2003) inventors, Bristol-Myers Squibb Company, assignee. N-Ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity. U.S. patent 6627629, September 30, 2003.
19. Kung TT, Stelts D, Zurcher JA, Watnick AS, Jones H, Mauser PJ, Fernandez X, Umland S, Kreutner W, Chapman RW, et al. (1994) Mechanisms of allergic pulmonary eosinophilia in the mouse. J Allergy Clin Immunol 94:1217-1224.
20. Lacy P and Moqbel R (2002) Immune effector functions of eosinophils in allergic airway inflammation. Curr Opin Allergy Clin Immunol 1:79-84.
21. Lilly CM, Nakamura H, Belostotsky OI, Haley KJ, Garcia-Zepada EA, Luster AD, and Israel E (2001) Eotaxin expression after segmental allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med 163:1669-1675.
22. Lloyd CM, Delaney T, Nguyen T, Tian J, Martinez-A C, Coyle AJ, and Gutierrez-Ramos JC (2000) CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial challenge in vivo. J Exp Med 191:265-273.
23. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcinday A, Alenius H, Friend DS, Oettgen HC, Gerard C, and Geha RS (2002) CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Investig 109:621-628.
24. Mattes J, Yang M, Mahalingam S, Kuehr J, Webb D, Simon L, Hogan SP, Koskinen A, McKenzie NJ, Dent LA, et al. (2002) Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 195:1433-1444.
25. Mould AW, Matthaei KI, Young IG, and Foster PS (1997) Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J Clin Investig 99:1064-1071.
26. Nakamura H, Luster AD, Nakamura T, In KH, Sonna LA, Deykin A, Israel E, Drazen JM, and Lilly CM (2001) Variant eotaxin: its effects on the asthma phenotype. J Allergy Clin Immunol 108:946-953.
27. Nakamura H, Weiss ST, Israel E, Luster AD, Drazen JM, and Lilly CM (1999) Eotaxin and impaired lung function in asthma. Am J Respir Crit Care Med 160:1952-1956.
28. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, and Boyce JA (1999) T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of mast cells in vitro. J Exp Med 190:267-280.
29. Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, and Mackay CR (1996a) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 183:2437-2448.
30. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Xhi X, Gonzalo JA, Newman W, et al. (1996b) Cloning of the human eosinophil chemoattractant eotaxin: expression, receptor binding and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Investig 97:604-612.
31. Romagnani P, De Paulis A, Beltrame C, Annunziato F, Dente V, Maggi E, Romagnani S, and Marone G (1999) Tryptase-chymase double positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am J Pathol 155:1195-1204.
32. Rothenberg MD, MacLean JA, Pearlman E, Luster AD, and Leder P (1997) Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 185:785-790.
33. Sallusto F, Mackay CR, and Lanzavecchia A (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science (Wash DC) 277:2005-2007.
34. Schuh JM, Blease K, Kunkel SL, and Hogaboam CM (2002) Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am J Physiol 283:L198-L204.
35. Shinkai A, Yoshisue H, Koike M, Shoji E, Nakagawa S, Saito A, Takeda T, Imabeppu S, Kato Y, Hanai N, et al. (1999) A novel human CC chemokine, eotaxin-3, which is expressed in IL-4 stimulated vascular endothelial cells, exhibits potent activity towards eosinophils. J Immunol 163:1602-1610.
36. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa CJ, Rao P, Ponath PD, Baggiolini M, and Dahinden CA (1997) High expression of the chemokine receptor CCR3 in human blood basophils: role in activation by eotaxin, MCP-4 and other chemokines. J Clin Investig 100:1137-1143.
37. Varnes JG, Gardner DS, Santella JBI, Duncia JV, Estrella M, Watson PS, Clark CM, Ko SS, Welch PK, Covington M, et al. (2004) Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists. Bioorg Med Chem Lett 14:1645-1649.
38. Watson PS, Ko SS, DeLucca GV, Santella JBI, Wacker DA, and Duncia JV (2004) inventors, Bristol-Myers Squibb Company, assignee. 2-Substituted-4- nitrogen heterocycles as modulators of chemokine receptor activity. U.S. patent 6706735, March 16, 2004.
39. Zlotnik A and Yoshie O (2000) Chemokines: a new classification system and their role in immunity. Immunity 12:121-127.