Effect of mast cell deficiency and leukotriene inhibition on the influx of eosinophils induced by eotaxin

Journal of Leukocyte Biology

Volumn 62, Issue 5, 1997, Pages 688-691

  Harris, R R ^a   Komater, V A ^a   Marett, R A ^a   Wilcox, D M ^a   Bell, R L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ABT 761; Zileuton

Indexed keywords

ATRELEUTON; CHEMOKINE; EOTAXIN; LIPOXYGENASE INHIBITOR; N [3 [5 (4 FLUOROPHENYLMETHYL) 2 THIENYL] 1 METHYL 2 PROPYNYL] N HYDROXYUREA; UNCLASSIFIED DRUG; ZILEUTON;

ALLERGY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; EOSINOPHIL; IMMUNOPATHOGENESIS; MAST CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SYMPTOMATOLOGY;

EID: 0030664303     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.5.688     Document Type: Article

References (26)

1. Lane, S. J., Lee, T. H. (1996) Section III: mechanisms of symptomatology. J. Allergy Clin. Immunol. 98, S67-S71.
2. Makino, S., Fukuda, T. (1995) Eosinophils and allergy in asthma. Allergy Proc. 16, 13-21.
3. Bousquet, J., Chanez, P., Vignola, A. M., Lacoste, J., Michel, F. B. (1994) Eosinophil inflammation in asthma. Am. J. Respir. Crit. Care Med. 150, 533-538.
4. Thomas, L. H., Warner, J. A. (1996) The eosinophil and its role in asthma. Gen. Pharmacol. 27, 593-597.
5. Weller, P. F. (1991) The immunobiology of eosinophils. N. Engl. J. Med. 321, 1110-1118.
6. Nagai, H., Yamaguchi, S., Maeda, Y., Tanaka, H. (1996) Role of mast cells, eosinophils, and IL-5 in the development of airway hyperresponsiveness in sensitized mice. Clin. Exp. Allergy 26, 642-647.
7. Okayama, Y., Kobayashi, H., Ishizuka, T., Holgate, S. A. T., Church, M. K., Mori, M. (1997) Activation of eosinophils by human mast cells. J. Allergy Clin. Immunol. 99, 494.
8. Kung, T. T., Stelts, D., Zurcher, J. A., Jones, H., Umland, S. P., Kreutner, W., Egan, R. W., Chapman, R. W. (1995) Mast cells modulate allergic pulmonary eosinophilia in mice. Am. J. Respir. Cell Mol. Biol. 12, 404-409.
9. Busse, W. W. (1996) The role of leukotrienes in asthma and allergic rhinitis. Clin. Exp. Allergy 26, 868-879.
10. Harris, R. R., Carter, G. W., Bell, R. L., Moore, J. L., Brooks, D. W. (1995) Clinical activity of leukotriene inhibitors. Int. J. Immunopharmacol. 17, 147-156.
11. Teran, L. M., Davies, D. E. (1996) The chemokines: their potential role in allergic inflammation. Clin. Exp. Allergy 26, 1005-1019.
12. Jose, P. J., Adcock, I. M., Griffiths-Johnson, D. A., Berkman, N., Wells, T. N. C., Williams, T. J., Power, C. A. (1994) Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea pig lungs. Biochem. Biophys. Res. Commun. 205, 788-794.
13. Ponath, P. D., Qin, S., Ringler, D. J., Clark-Lewis, I., Wang, J., Kassen, N., Smith, H., Shi, X., Gonzalo, J., Newman, W. Gutierrez-Ramos, J., Mackay, C. R. (1996) Cloning of the human eosinophil chemoattractant, eotaxin. J. Clin. Invest. 97, 604-612.
14. Rothenberg, M. E., Luster, A. D., Leder, P. (1995) Murine eotaxin - an eosinophil chemoattractant inducible in endothelial cells and in interleukin-4 induced tumor suppression. J. Exp. Med. 181, 1211-1216.
15. Combadiere, C., Ahuja, S. K., Murphy, P. M. (1995) Cloning and functional expression of a human eosinophil cc chemokine receptor. J. Biol. Chem. 270, 16491-16494.
16. Stafford, S., Alam, R. (1997) Lipoxgenase metabolites are essential for the chemotactic activity of RANTES. J. Allergy Clin. Immunol. 99, 490 (abstract S121).
17. Rothenberg, M. E., Ownbey, R., Mehlhop, P. D., Loiselle, P. M., Van De Rijn, M., Bonventre, J. V., Oettgen, H. C., Leder, P., Luster, A. D. (1996) Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin-5 in mice. Mol. Med. 2, 334-348.
18. Collins, P. D., Marleau, S., Griffiths-Johnson, D. A., Jose, P. J., Williams, T. J. (1995) Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J. Exp. Med. 182, 1169-1174.
19. v mice and their increase by bone marrow transplant. Blood 52, 447-452.
20. Jacoby, W., Cammarata, P. V., Findlay, S., Pincus, S. H. (1984) Anaphylaxis in mast cell-deficient mice. J. Invest. Dermatol. 83, 302-304.
21. Carter, G. W., Young, P. R., Albert, D. H., Bouska, J., Dyer, R., Bell, R. L., Summers, J. B., Brooks, D. W. (1991) 5-Lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther. 256, 929-937.
22. Bell, R. L., Harris, R. R., Malo, P. E., Bouska, J. B., Shaughnessy, T. K., Hulkower, K. I., Brooks, C. D. W., Carter, G. W. (1997) ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J. Pharmacol. Exp. Ther. 280, 1366-1373.
23. 4. J. Biol. Chem. 264, 19469-19472.
24. Adams, D. H., Lloyd, A. R. (1997) Chemokines: leukocyte recruitment and activation cytokines. Lancet 349, 490-495.
25. Yamada, H., Hirai, K., Miyamasu, M., Iikura, M., Misaki, Y., Shoji, S., Takaishi, T., Kasahara, T., Morita, Y., Ito, K. (1997) Eotaxin is a potent chemotaxin for human basophils. Biochem. Biophys. Res. Commun. 231, 365-368.
26. Mould, A. W., Matthaei, K. I., Young, I. G., Foster, P. S. (1997) Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J. Allergy Clin. Immunol. 99, 1064-1071.