Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo

Journal of Neuroscience

Volumn 26, Issue 22, 2006, Pages 5978-5989

  Escartin, Carole ^a   Brouillet, Emmanuel ^a   Gubellini, Paolo ^c   Trioulier, Yaël ^a   Jacquard, Carine ^a   Smadja, Claire ^d   Knott, Graham W ^e   Goff, Lydia Kerkerian Le ^c   Déglon, Nicole ^b,f   Hantraye, Philippe ^a,b,f   Bonvento, Gilles ^a  

^a CNRS   (France)

^b SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^c AIX MARSEILLE UNIVERSITÉ   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

^f INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

Activated astrocytes; CNTF; Excitotoxicity; Glucose uptake; Glutamate transporters; Rafts

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; FLUORODEOXYGLUCOSE F 18; GLUTAMATE TRANSPORTER; NEUROTROPHIC FACTOR; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL CULTURE; CILIATED EPITHELIUM; CONTROLLED STUDY; CORPUS STRIATUM; GENE TARGETING; GLYCOSYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL MEMBRANE; COCULTURE; CYTOLOGY; DRUG EFFECT; GENE VECTOR; GENETICS; HUMAN; LENTIVIRINAE; LEWIS RAT; NERVE CELL; PHYSIOLOGY;

ANIMALS; ASTROCYTES; CILIARY NEUROTROPHIC FACTOR; COCULTURE TECHNIQUES; CORPUS STRIATUM; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; GENETIC VECTORS; GLUTAMIC ACID; HUMANS; LENTIVIRUS; MALE; MEMBRANE MICRODOMAINS; NEURONS; RATS; RATS, INBRED LEW;

EID: 33745261791     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0302-06.2006     Document Type: Article

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