Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors

Journal of Molecular Endocrinology

Volumn 24, Issue 2, 2000, Pages 165-182

  Sartorius, C A ^a   Takimoto, G S ^a   Richer, J K ^a   Tung, L ^a   Horwitz, K B ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; ESTROGEN RECEPTOR; HOLOENZYME; HYBRID PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROGESTERONE RECEPTOR; PROTEIN KINASE; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; MAMMARY GLAND FUNCTION; PRIORITY JOURNAL; PROGESTERONE METABOLISM; TATA BOX; YEAST;

EID: 0034027552     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0240165     Document Type: Article

References (64)

1. Althaus FR, Hofferer L, Kleczkowska HE, Malanga M, Naegeli H, Panzeter PL & Realini CA 1994 Histone shuttling by poly ADP-ribosylation. Molecular and Cellular Biochemistry 138 53-59.
2. Aoufouchi S & Shall S 1997 Regulation by phosphorylation of Xenopus laevis poly(ADP-ribose) polymerase enzyme activity during oocyte maturation. Biochemical Journal 325 543-551.
3. Arnold SF, Obourn JD, Yudt MR, Carter TH & Notides AC 1995 in vivo and in vitro phosphorylation of the human estrogen receptor. Journal of Steroid Biochemistry and Molecular Biology 52 159-171.
4. Bandyopadhyay D, Mandal M, Adam L, Mendelsohn J & Kumar R 1998 Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. Journal of Biological Chemistry 273 1568-1573.
5. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA & Jackson SP 1995 Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80 813-823.
6. Carter T, Vancurova I, Sun I, Lou W & DeLeon S 1990 A DNA-activated protein kinase from HeLa cell nuclei. Molecular and Cellular Biology 10 6460-6471.
7. Cherney BW, McBride OW, Chen DF, Alkhatib H, Bhatia K, Hensley P & Smulson ME 1987 cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase. Proceedings of the National Academy of Sciences of the USA 84 8370-8374.
8. Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E & Fujita T 1996 The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. Journal of Biological Chemistry 271 8593-8598.
9. Clarke CL & Sutherland RL 1990 Progestin regulation of cellular proliferation. Endocrine Reviews 11 266-301.
10. Ding R, Pommier Y, Kang VH & Smulson M 1992 Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. Journal of Biological Chemistry 267 12804-12812.
11. Durkacz BW, Omidiji O, Gray DA & Shall S 1980 (ADP-ribose)n participates in DNA excision repair. Nature 283 593-596.
12. Dvir A, Stein LY, Calore BL & Dynan WS 1993 Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. Journal of Biological Chemistry 268 10440-10447.
13. Dynan WS & Yoo S 1998 Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Research 26 1551-1559.
14. Feldmann H & Winnacker EL 1993 A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. Journal of Biological Chemistry 268 12895-12900.
15. Genersch E, Eckerskorn C, Lottspeich F, Herzog C, Kuhn K & Poschl E 1995 Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. EMBO Journal 14 791-800.
16. Giffin W, Torrance H, Saffran H, MacLeod HL & Hache RJ 1994 Repression of mouse mammary tumor virus transcription by a transcription factor complex. Binding of individual components to separated DNA strands. Journal of Biological Chemistry 269 1449-1459.
17. Giffin W, Torrance H, Rodda DJ, Prefontaine GG, Pope L & Hache RJ 1996 Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. Nature 380 265-268.
18. Giffin W, Kwast-Welfeld J, Rodda DJ, Prefontaine GG, Traykova-Andonova M, Zhang Y, Weigel NL, Lefebvre YA & Hache RJ 1997 Sequence-specific DNA binding and transcription factor phosphorylation by Ku autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor. Journal of Biological Chemistry 272 5647-5658.
19. Gottlieb TM & Jackson SP 1993 The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72 131-142.
20. Hard T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA & Kaptein R 1990 Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249 137-160.
21. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW & Jackson SP 1995 DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82 849-856.
22. Horwitz KB 1992 The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocrine Reviews 13 146-163.
23. Huang J, Nueda A, Yoo S & Dynan WS 1997 Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase. Journal of Biological Chemistry 272 26009-26016.
24. Jackson SP, Mac-Donald JJ, Lees-Miller S & Tjian R 1990 GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63 155-165.
25. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE & Poirier GG 1993 Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Research 53 3976-3985.
26. Kim D, Ouyang H, Yang SH, Nussenzweig A, Burgman P & Li GC 1995 A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. Journal of Biological Chemistry 270 15277-15284.
27. Knuth MW, Gunderson SI, Thompson NE, Strasheim LA & Burgess RR 1990 Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. Journal of Biological Chemistry 265 17911-17920.
28. Koelle MR, Talbot WS, Segraves WA, Bender MT, Cherbas P & Hogness DS 1991 The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67 59-77.
29. Kuhn A, Gottlieb TM, Jackson SP & Grummt I 1995 DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes and Development 9 193-203.
30. Labhart P 1995 DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I. Proceedings of the National Academy of Sciences of the USA 92 2934-2938.
31. Leber R, Wise TW, Mizuta R & Meek K 1998 The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. Journal of Biological Chemistry 273 1794-1801.
32. Lees-Miller SP, Chen YR & Anderson CW 1990 Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Molecular and Cellular Biology 10 6472-6481.
33. Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E & Anderson CW 1992 Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Molecular and Cellular Biology 12 5041-5049.
34. Lindahl T, Satoh MS, Poirier GG & Klungland A 1995 Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends in Biochemistry 20 405-411.
35. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR & Sigler PB 1991 Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352 497-505.
36. Maldonado E, Shiekhattar R, Sheldon M, Cho H, Drapkin R, Rickert P, Lees E, Anderson CW, Linn S & Reinberg D 1996 A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature 381 86-89.
37. Masutani M, Nozaki T, Wakabayashi K & Sugimura T 1995 Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation. Biochimie 77 462-165.
38. Murdoch WJ 1998 Perturbation of sheep ovarian surface epithelial cells by ovulation: evidence for roles of progesterone and poly(ADP-ribose) polymerase in the restoration of DNA integrity. Journal of Endocrinology 156 503-508.
39. Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC & Li GC 1996 Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382 551-555.
40. Oei SL, Griesenbeck J, Ziegler M & Schweiger M 1998 A novel function of poly(ADP-ribosyl)ation: silencing of RNA polymerase II-dependent transcription. Biochemistry 37 1465-1469.
41. Okumura K, Takagi S, Sakaguchi G, Naito K, Minoura-Tada N, Kobayashi H, Mimori T, Hinuma Y & Igarashi H 1994 Autoantigen Ku protein is involved in DNA binding proteins which recognize the U5 repressive element of human T-cell leukemia virus type I long terminal repeat. FEBS Letters 356 94-100.
42. Peterson SR, Jesch SA, Chamberlin TN, Dvir A, Rabindran SK, Wu C & Dynan WS 1995a Stimulation of the DNA-dependent protein kinase by RNA polymerase II transcriptional activator proteins. Journal of Biological Chemistry 270 1449-1454.
43. Peterson SR, Kurimasa A, Oshimura M, Dynan WS, Bradbury EM & Chen DJ 1995b Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proceedings of the National Academy of Sciences of the USA 92 3171-3174.
44. Reeves WH & Sthoeger ZM 1989 Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. Journal of Biological Chemistry 264 5047-5052.
45. Richer JK, Lange CA, Manning NG, Owen G, Powell R & Horwitz KB 1998 Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Journal of Biological Chemistry 278 31317-31326.
46. Roberts MR, Han Y, Fienberg A, Hunihan L & Ruddle FH 1994 A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen. Proceedings of the National Academy of Sciences of the USA 91 6354-6358.
47. Romero F, Dargemont C, Pozo F, Reeves WH, Camonis J, Gisselbrecht S & Fischer S 1996 p95 vav associates with the nuclear protein Ku-70. Molecular and Cellular Biology 16 37-44.
48. Rosenthal D, Hong T, Cherney B, Zhang S, Shima T, Danielsen M & Smulson M 1994 Expression and characterization of a fusion protein between the catalytic domain of poly(ADP-ribose) polymerase and the DNA binding domain of the glucocorticoid receptor. Biochemical and Biophysical Research Communications 202 880-887.
49. Sartorius CA, Groshong SD, Miller LA, Powell RL, Tung L, Takimoto GS & Horwitz KB 1994a New T47D breast cancer cell lines for the independent study of progesterone B-and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Research 54 3868-3877.
50. Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS & Horwitz KB 1994b A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Molecular Endocrinology 8 1347-1360.
51. Schena M, Freedman LP & Yamamoto KR 1989 Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes and Development 3 1590-1601.
52. Schwabe JW, Chapman L, Finch JT & Rhodes D 1993 The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements. Cell 75 567-578.
53. Schwerk C, Klotzbucher M, Sachs M, Liber V & Klein-Hitpass L 1995 Identification of a transactivation function in the progesterone receptor that interacts with the TAFII110 subunit of the TFIID complex. Journal of Biological Chemistry 270 21331-21338.
54. Stuiver MII, Coenjaerts FE & van der Vliet PC 1990 The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes. Journal of Experimental Medicine 172 1049-1054.
55. Suwa A, Hirakata M, Takeda Y, Jesch SA, Mimori T & Hardin J 1994 DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double stranded DNA. Proceedings of the National Academy of Sciences of the USA 91 6904-6908.
56. Takimoto GS, Tasset DM, Eppert AC & Horwitz KB 1992 Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-mdependent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299. Proceedings of the National Academy of Sciences of the USA 89 3050-3054.
57. Ting NS, Kao PN, Chan DW, Lintott LG & Lees-Miller SP 1998 DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. Journal of Biological Chemistry 273 2136-2145.
58. Tsai MJ & O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Biochemistry 63 451-486.
59. Wang J, Satoh M, Pierani A, Schmitt J, Chou CH, Stunnenberg HG, Roeder RG & Reeves WH 1994 Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers. Journal of Cell Science 107 3223-3233.
60. Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M & Wagner EF 1995 Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes und Development 9 509-520.
61. Weigel NL, Carter TH, Schrader WT & O'Malley BW 1992 Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays. Molecular Endocrinology 6 8-14.
62. Yaneva M, Wen J, Ayala A & Cook R 1989 cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. Journal of Biological Chemistry 264 13407-13411.
63. Yavuzar U, Smith GCM, Bliss T, Werner D & Jackson SP 1998 DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes and Development 12 2188-2199.
64. Zhu C, Bogue MA, Lim DS, Hasty P & Roth DB 1996 Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86 379-389.