pS2 gene expression in HepG2 cells: Complex regulation through crosstalk between the estrogen receptor α, an estrogen-responsive element, and the activator protein 1 response element

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1273-1283

  Barkhem, Tomas ^a   Haldosén, Lars Arne ^b   Gustafsson, Jan Åke ^b   Nilsson, Stefan ^a  

^a Karo Bio   (Sweden)

^b Department of Medical Nutrition ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MOXESTROL; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; PEPTIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; PROTEIN PS2; TAMOXIFEN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; CELL STRAIN HEPG2; CONTROLLED STUDY; ESTROGEN RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID MOTIFS; BINDING SITES; ENZYME INHIBITORS; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; HUMANS; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; PROTEIN KINASE INHIBITORS; PROTEINS; RECEPTOR CROSS-TALK; RECEPTORS, CELL SURFACE; RECEPTORS, ESTROGEN; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0036262430     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1273     Document Type: Article

References (40)

1. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
2. Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: Regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes
3. Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence
4. Novel steroidal pure antiestrogens
5. Molecular basis of agonism and antagonism in the oestrogen receptor
6. PI3 kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
7. Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3′,5′-monophosphate in MCF7 cells
8. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
9. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1
10. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
11. Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex
12. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions
13. Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor
14. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
15. The regulation of AP-1 activity by mitogen-activated protein kinases
16. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
17. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
18. Cloning of a novel receptor expressed in rat prostate and ovary
19. Functional domains of the human estrogen receptor
20. Estrogen receptor pathways to AP-1
21. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits
22. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
23. Peptide antagonists of the human estrogen receptor
24. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta
25. Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding
26. Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage
27. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells
28. Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa
29. Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2
30. Ligand-, cell- and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements
31. Estrogen receptor-dependent formation of two distinct multiprotein complexes on the human pS2 gene regulatory segment. Participation of a c-fos related protein
32. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
33. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
34. Immunolocalisation of oestrogen receptor beta in human tissues
35. Characterization of the physical interaction between estrogen receptor alpha and JUN proteins
36. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
37. The human estrogen receptor has two independent nonacidic transcriptional activation functions
38. Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer
39. Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens
40. Estrogen receptor activation function 1 works by binding p160 coactivator proteins