Wound healing in the biliary tree of liver allografts

Cell Transplantation

Volumn 15, Issue SUPPL. 1, 2006, Pages

  Demetris, A J ^a,b   Fontes, Paulo ^a   Lunz III, John G ^a   Specht, Susan ^a   Murase, Noriko ^a   Marcos, Amadeo ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Biliary strictures; Liver transplantation; Wound healing

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; MESSENGER RNA; STAT3 PROTEIN; TREFOIL PEPTIDE;

AGE; ALLOGRAFT; BILE DUCT ATRESIA; BILE DUCT OBSTRUCTION; BLOOD PRESSURE VARIABILITY; CELL PROLIFERATION; CONFERENCE PAPER; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOTHERAPY; ISCHEMIA; LIVER BLOOD FLOW; LIVER GRAFT; LIVER PARENCHYMA; LIVER TRANSPLANTATION; MYOFIBROBLAST; OBESITY; PATHOGENESIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TISSUE PRESERVATION; WOUND HEALING;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 33745196728     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000006783982386     Document Type: Conference Paper

References (104)

1. Adam, R.; Astarcioglu, I.; Raccuia, J. S.; Ducot, B.; Reynes, M.; Bismuth, H. Beneficial effects of Eurocollins as aortic flush for the procurement of human livers. Transplantation 61(5):705-709; 1996.
2. Akiyama, T.; Hasegawa, T.; Sejima, T.; Sahara, H.; Seto, K.; Saito, H.; Takashima, S. Serum and bile interleukin 6 after percutaneous transhepatic cholangio-drainage. Hepatogastroenterology 45(21):665-671; 1998.
3. Alpini, G.; McGill, J. M.; Larusso, N. F. The pathobiology of biliary epithelia. Hepatology 35(5):1256-1268; 2002.
4. Alpini, G.; Ulrich, C.; Roberts, S.; Phillips, J. O.; Ueno, Y.; Podila, P. V.; Colegio, O.; LeSage, G. D.; Miller, L. J.; LaRusso, N. F. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am. J. Physiol. 272(2 Pt. 1):G289-297; 1997.
5. Bonilla, I. E.; Tanabe, K.; Strittmatter, S. M. Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth. J. Neurosci. 22(4):1303-1315; 2002.
6. Busuttil, R. W.; Tanaka, K. The utility of marginal donors in liver transplantation. Liver Transpl. 9(7):651-663; 2003.
7. Cabral, A.; Voskamp, P.; Cleton-Jansen, A. M.; South, A.; Nizetic, D.; Backendorf, C. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. J. Biol. Chem. 276(22):19231-19237; 2001.
8. Camargo, Jr., C. A.; Madden, J. F.; Gao, W.; Selvan, R. S.; Clavien, P. A. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 26(6):1513-1520; 1997.
9. Carlson, M. A.; Longaker, M. T. The fibroblast-populated collagen matrix as a model of wound healing: A review of the evidence. Wound Repair Regen. 12(2): 134-147; 2004.
10. Carrasco, L.; Sanchez-Bueno, F.; Sola, J.; Ruiz, J. M.; Ramirez, P.; Robles, R.; Rodriquez, J. M.; Parrilla, P. Effects of cold ischemia time on the graft after orthotopic liver transplantation. A bile cytological study. Transplantation 61(3):393-396; 1996.
11. Demetris, A.; Crawford, J.; Nalesnik, M.; Randhawa, P.; Wu, T.; Minervini, M. Transplantation pathology of the liver. In: Surgical pathology of the GI tract, liver, biliary track and pancreas. Philadelphia: WB Saunders; 2004: 909-966.
12. Demetris, A. J. Ischemic cholangitis. Mayo Clin. Proc. 67(6):601-602; 1992.
13. Demetris, A. J.; Lunz, J. G.; Subbotin, V.; Wu, T.; Nozaki, I.; Contrucci, S.; Yin, X. Participation of cytokines and growth factors in biliary epithelial proliferation and mito-inhibition during ductular reactions. In: Alpini, G.; Alvaro, D.; LeSage, G.; LaRusso, N., eds. The pathophysiology of the biliary epithelia. Georgetown, TX: Landes Bioscience; 2003:167-191.
14. Demetris, A. J.; Murase, N.; Nakamura, K.; Iwaki, Y.; Yagihashi, A.; Valdivia, L.; Todo, S.; Iwatsuki, S.; Takaya, S.; Fung, J. J.; et al. Immunopathology of antibodies as effectors of orthotopic liver allograft rejection. Semin. Liver Dis. 12(1):51-59; 1992.
15. Demetris, A. J.; Nakamura, K.; Yagihashi, A.; Iwaki, Y.; Takaya, S.; Hartman, G. G.; Murase, N.; Bronsther, O.; Manez, R.; Fung, J. J.; et al. A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies. Hepatology 16(3):671-681; 1992.
16. Dignass, A.; Lynch-Devaney, K.; Kindon, H.; Thim, L.; Podolsky, D. K. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J. Clin. Invest. 94(1):376-383; 1994.
17. Elder, J. T.; Zhao, X. Evidence for local control of gene expression in the epidermal differentiation complex. Exp. Dermatol. 11(5):406-412; 2002.
18. Ernst, M.; Inglese, M.; Waring, P.; Campbell, I. K.; Bao, S.; Clay, F. J.; Alexander, W. S.; Wicks, I. P.; Tarlinton, D. M.; Novak, U.; Heath, J. K.; Dunn, A. R. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med. 194(2):189-203; 2001.
19. Ezure, T.; Sakamoto, T.; Tsuji, H.; Lunz, 3rd, J. G.; Murase, N.; Fung, J. J.; Demetris, A. J. The development and compensation of biliary cirrhosis in interleukin-6-deficient mice. Am. J. Pathol. 156(5):1627-1639; 2000.
20. Gallucci, R. M.; Simeonova, P. P.; Matheson, J. M.; Kommineni, C.; Guriel, J. L.; Sugawara, T.; Luster, M. I. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J. 14(15): 2525-2531; 2000.
21. Gao, B. Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure. Alcohol 34(1):59-65; 2004.
22. Geng, Z. M.; Yao, Y. M.; Liu, Q. G.; Niu, X. J.; Liu, X. G. Mechanism of benign biliary stricture: A morphological and immunohistochemical study. World J. Gastroenterol. 11(2):293-295; 2005.
23. Gibbs, S.; Ponec, M. Intrinsic regulation of differentiation markers in human epidermis, hard palate and buccal mucosa. Arch. Oral Biol. 45(2):149-158; 2000.
24. Graziadei, I. W.; Wiesner, R. H.; Batts, K. P.; Marotta, P. J.; LaRusso, N. F.; Porayko, M. K.; Hay, J. E.; Gores, G. J.; Charlton, M. R.; Ludwig, J.; Poterucha, J. J.; Steers, J. L.; Krom, R. A. Recurrence of primary sclerosing cholangitis following liver transplantation. Hepatology 29(4):1050-1056; 1999.
25. Greif, F.; Bronsther, O. L.; Van Thiel, D. H.; Casavilla, A.; Iwatsuki, S.; Tzakis, A.; Todo, S.; Fung, J. J.; Starzl, T. E. The incidence, timing, and management of biliary tract complications after orthotopic liver transplantation. Ann. Surg. 219(1):40-45; 1994.
26. Gum, Jr., J. R.; Hicks, J. W.; Gillespie, A. M.; Carlson, E. J.; Komuves, L.; Karnik, S.; Hong, J. C.; Epstein, C. J.; Kim, Y. S. Goblet cell-specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice. Am. J. Physiol. 276(3 Pt. 1):G666-676; 1999.
27. Hertel, S. C.; Chwieralski, C. E.; Hinz, M.; Rio, M. C.; Tomasetto, C.; Hoffmann, W. Profiling trefoil factor family (TFF) expression in the mouse: identification of an antisense TFF1-related transcript in the kidney and liver. Peptides 25(5):755-762; 2004.
28. Hinz, B.; Gabbiani, G. Cell-matrix and cell-cell contacts of myofibroblasts: Role in connective tissue remodeling. Thromb. Haemost. 90(6):993-1002; 2003.
29. Hong, F.; Radaeva, S.; Pan, H. N.; Tian, Z.; Veech, R.; Gao, B. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 40(4):933-941; 2004.
30. Hooper, L. V.; Wong, M. H.; Thelin, A.; Hansson, L.; Falk, P. G.; Gordon, J. I. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291(5505):881-884; 2001.
31. Ikeda, H.; Inao, M.; Fujiwara, K. Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells. Biochem. Biophys. Res. Commun. 227(2):322-327; 1996.
32. Jacinto, A.; Martinez-Arias, A.; Martin, P. Mechanisms of epithelial fusion and repair. Nat. Cell Biol. 3(5): E117-123; 2001.
33. Kanai, M.; Mullen, C.; Podolsky, D. K. Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells. Proc. Natl. Acad. Sci. USA 95(1):178-182; 1998.
34. Kawaguchi, K.; Sakaida, I.; Tsuchiya, M.; Omori, K.; Takami, T.; Okita, K. Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem. Biophys. Res. Commun. 315(1): 187-195; 2004.
35. Kimizuka, K.; Nakao, A.; Nalesnik, M. A.; Demetris, A. J.; Uchiyama, T.; Ruppert, K.; Fink, M. P.; Stolz, D. B.; Murase, N. Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation. Am. J. Transplant. 4(4):482-494; 2004.
36. Kimmings, A. N.; van Deventer, S. J.; Obertop, H.; Rauws, E. A.; Huibregtse, K.; Gouma, D. J. Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage. Gut 46(5):725-731; 2000.
37. Kindon, H.; Pothoulakis, C.; Thim, L.; Lynch-Devaney, K.; Podolsky, D. K. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology 109(2):516-523; 1995.
38. Kootstra, G.; Kievit, J.; Nederstigt, A. Organ donors: Heartbeating and non-heartbeating. World J. Surg. 26(2): 181-184; 2002.
39. Kukan, M.; Haddad, P. S. Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts. Liver Transpl. 7(5):381-400; 2001.
40. Lamireau, T.; Zoltowska, M.; Levy, E.; Yousef, I.; Rosenbaum, J.; Tuchweber, B.; Desmouliere, A. Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. Life Sci. 72(12): 1401-1411; 2003.
41. Liu, Z.; Sakamoto, T.; Ezure, T.; Yokomuro, S.; Murase, N.; Michalopoulos, G.; Demetris, A. J. Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type 1 ductular reaction in mice: interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Hepatology 28(5):1260-1268; 1998.
42. Liu, Z.; Sakamoto, T.; Yokomuro, S.; Ezure, T.; Subbotin, V.; Murase, N.; Contrucci, S.; Demetris, A. J. Acute obstructive cholangiopathy in interleukin-6 deficient mice: Compensation by leukemia inhibitory factor (LIF) suggests importance of gp-130 signaling in the ductular reaction. Liver 20(2):114-124; 2000.
43. Loinaz, C.; Gonzalez, E. M. Marginal donors in liver transplantation. Hepatogastroenterology 47(31):256-263; 2000.
44. Ludwig, J.; Batts, K. P.; MacCarty, R. L. Ischemic cholangitis in hepatic allografts. Mayo Clin. Proc. 67(6):519-526; 1992.
45. Mammen, J. M.; Matthews, J. B. Mucosal repair in the gastrointestinal tract. Crit. Care Med. 31(8 Suppl.): S532-537; 2003.
46. Marenholz, I.; Zirra, M.; Fischer, D. F.; Backendorf, C.; Ziegler, A.; Mischke, D. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. Genome Res. 11(3):341-355; 2001.
47. Mashimo, H.; Wu, D. C.; Podolsky, D. K.; Fishman, M. C. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 274(5285):262-265; 1996.
48. Matsumoto, K.; Fujii, H.; Michalopoulos, G.; Fung, J. J.; Demetris, A. J. Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. Hepatology 20(2):376-382; 1994.
49. McDonald, V.; Matalon, T. A.; Patel, S. K.; Brunner, M. C.; Sankary, H.; Foster, P.; Williams, J. Biliary strictures in hepatic transplantation. J. Vasc. Interv. Radiol. 2(4):533-538; 1991.
50. Minor, T.; Hachenberg, A.; Tolba, R.; Pauleit, D.; Akbar, S. Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion. Transplantation 71(12):1792-1796; 2001.
51. Minor, T.; Olschewski, P.; Tolba, R. H.; Akbar, S.; Kocalkova, M.; Dombrowski, F. Liver preservation with HTK: salutary effect of hypothermie aerobiosis by either gaseous oxygen or machine perfusion. Clin. Transplant. 16(3):206-211; 2002.
52. Mischke, D.; Korge, B. P.; Marenholz, I.; Volz, A.; Ziegler, A. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21. J. Invest. Dermatol. 106(5):989-992; 1996.
53. Miyahara, T.; Schrum, L.; Rippe, R.; Xiong, S.; Yee, Jr., H. F.; Motomura, K.; Anania, F. A.; Willson, T. M.; Tsukamoto, H. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J. Biol. Chem. 275(46):35715-35722; 2000.
54. Mor, E.; Klintmalm, G. B.; Gonwa, T. A.; Solomon, H.; Holman, M. J.; Gibbs, J. F.; Watemberg, I.; Goldstein, R. M.; Husberg, B. S. The use of marginal donors for liver transplantation. A retrospective study of 365 liver donors. Transplantation 53(2):383-386; 1992.
55. Mueller, A.; O'Rourke, J.; Grimm, J.; Guillemin, K.; Dixon, M. F.; Lee, A.; Falkow, S. Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proc. Natl. Acad. Sci. USA 100(3):1292-1297; 2003.
56. Naftalin, R. Alterations in colonic barrier function caused by a low sodium diet or ionizing radiation. J. Environ. Pathol. Toxicol. Oncol. 23(2):79-97; 2004.
57. Nakanuma, Y.; Katayanagi, K.; Terada, T.; Saito, K. Intrahepatic peribiliary glands of humans. I. Anatomy, development and presumed functions. J. Gastroenterol. Hepatol. 9(1):75-79; 1994.
58. Nakanuma, Y.; Sasaki, M.; Terada, T.; Harada, K. Intrahepatic peribiliary glands of humans. II. Pathological spectrum. J. Gastroenterol. Hepatol. 9(1):80-86; 1994.
59. Noack, K.; Bronk, S. F.; Kato, A.; Gores, G. J. The greater vulnerability of bile duct cells to reoxygenation injury than to anoxia. Implications for the pathogenesis of biliary strictures after liver transplantation. Transplantation 56(3):495-500; 1993.
60. Nozaki, I.; Lunz, 3rd, J. G.; Specht, S.; Park, J. I.; Giraud, A. S.; Murase, N.; Demetris, A. J. Regulation and function of trefoil factor family 3 expression in the biliary tree. Am. J. Pathol. 165(6):1907-1920; 2004.
61. Nozaki, I.; Lunz, J. G.; Specht, S.; Stolz, D. B.; Taguchi, K.; Subbotin, V. M.; Murase, N.; Demetris, A. J. Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. Lab. Invest. 85:109-123; 2005.
62. Patel, S.; Kartasova, T.; Segre, J. A. Mouse Sprr locus: A tandem array of coordinately regulated genes. Mamm. Genome 14(2):140-148; 2003.
63. Paumgartner, G.; Beuers, U. Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited. Hepatology 36(3):525-531; 2002.
64. Pirenne, J.; Gunson, B.; Khaleef, H.; Hubscher, S.; Afford, S.; McMaster, P.; Adams, D. Influence of ischemia-reperfusion injury on rejection after liver transplantation. Transplant. Proc. 29(l-2):366-367; 1997.
65. Pirenne, J.; Van Gelder, F.; Coosemans, W.; Aerts, R.; Gunson, B.; Koshiba, T.; Fourneau, I.; Mirza, D.; Van Steenbergen, W.; Fevery, J.; Nevens, F.; McMaster, P. Type of donor aortic preservation solution and not cold ischemia time is a major determinant of biliary strictures after liver transplantation. Liver Transpl. 7(6):540-545; 2001.
66. Podolsky, D. K.; Lynch-Devaney, K.; Stow, J. L.; Oates, P.; Murgue, B.; DeBeaumont, M.; Sands, B. E.; Mahida, Y. R. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J. Biol. Chem. 268(9):6694-6702; 1993.
67. Ramadori, G.; Saile, B. Portal tract fibrogenesis in the liver. Lab. Invest. 84(2):153-159; 2004.
68. Ramos, S. G.; Montenegro, A. P.; Goissis, G.; Rossi, M. A. Captopril reduces collagen and mast cell and eosinophil accumulation in pig serum-induced rat liver fibrosis. Pathol. Int. 44(9):655-661; 1994.
69. Redd, M. J.; Cooper, L.; Wood, W.; Stramer, B.; Martin, P. Wound healing and inflammation: Embryos reveal the way to perfect repair. Philos. Trans. R Soc. Lond. B Biol. Sci. 359(1445):777-784; 2004.
70. Reddy, S. P.; Konkin, T.; Wu, R. Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B. Gene 224(1-2):59-66; 1998.
71. Rio, M. C.; Bellocq, J. P.; Daniel, J. Y.; Tomasetto, C.; Lathe, R.; Chenard, M. P.; Batzenschlager, A.; Chambon, P. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 241(4866):705-708; 1988.
72. Robertson, F. G.; Harris, J.; Naylor, M. J.; Oakes, S. R.; Kindblom, J.; Dillner, K.; Wennbo, H.; Tornell, J.; Kelly, P. A.; Green, J.; Ormandy, C. J. Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology 144(7):3196-3205; 2003.
73. Rosen, H. R.; Winkle, P. J.; Kendall, B. J.; Diehl, D. L. Biliary interleukin-6 and tumor necrosis factor-alpha in patients undergoing endoscopie retrograde cholangiopancreatography. Dig. Dis. Sci. 42(6):1290-1294; 1997.
74. Safadi, R.; Friedman, S. L. Hepatic fibrosis-role of hepatic stellate cell activation. Med. Gen. Med. 4(3):27; 2002.
75. Sanchez-Urdazpal, L.; Gores, G. J.; Ward, E. M.; Maus, T. P.; Wahlstrom, H. E.; Moore, S. B.; Wiesner, R. H.; Krom, R. A. Ischemic-type biliary complications after orthotopic liver transplantation. Hepatology 16(1):49-53; 1992.
76. Sano, S.; Itami, S.; Takeda, K.; Tarutani, M.; Yamaguchi, Y.; Miura, H.; Yoshikawa, K.; Akira, S.; Takeda, J. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18(17):4657-4668; 1999.
77. Sasaki, M.; Tsuneyama, K.; Nakanuma, Y. Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma. Lab. Invest. 83(10):1403-1413; 2003.
78. Sasaki, M.; Tsuneyama, K.; Saito, T.; Kataoka, H.; Mollenhauer, J.; Poustka, A.; Nakanuma, Y. Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Liver Int. 24(1):29-37; 2004.
79. Scotte, M.; Daveau, M.; Hiron, M.; Delers, F.; Lemeland, J. F.; Teniere, P.; Lebreton, J. P. Interleukin-6 (IL-6) and acute-phase proteins in rats with biliary sepsis. Eur. Cytokine Netw. 2(3):177-182; 1991.
80. Sebagh, M.; Farges, O.; Kalil, A.; Samuel, D.; Bismuth, H.; Reynes, M. Sclerosing cholangitis following human orthotopic liver transplantation. Am. J. Surg. Pathol. 19(1):81-90; 1995.
81. Selzner, M.; Graf, R.; Clavien, P. A. IL-6: A magic potion for liver transplantation? Gastroenterology 125(1): 256-259; 2003.
82. Shivakumar, P.; Campbell, K. M.; Sabla, G. E.; Miethke, A.; Tiao, G.; McNeal, M. M.; Ward, R. L.; Bezerra, J. A. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J. Clin. Invest. 114(3):322-329; 2004.
83. Song, H. J.; Poy, G.; Darwiche, N.; Lichti, U.; Kuroki, T.; Steinert, P. M.; Kartasova, T. Mouse Sprr2 genes: A clustered family of genes showing differential expression in epithelial tissues. Genomics 55(1):28-42; 1999.
84. Srivatsa, G.; Giraud, A. S.; Ulaganathan, M.; Yeomans, N. D.; Dow, C.; Nicoll, A. J. Biliary epithelial trefoil peptide expression is increased in biliary diseases. Histopathology 40(3):261-268; 2002.
85. Stern, L. E.; Erwin, C. R.; Falcone, R. A.; Huang, F. S.; Kemp, C. J.; Williams, J. L.; Warner, B. W. cDNA microarray analysis of adapting bowel after intestinal resection. J. Pediatr. Surg. 36(1):190-195; 2001.
86. Sun, Z.; Klein, A. S.; Radaeva, S.; Hong, F.; El-Assal, O.; Pan, H. N.; Jaruga, B.; Batkai, S.; Hoshino, S.; Tian, Z.; Kunos, G.; Diehl, A. M.; Gao, B. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 125(1):202-215; 2003.
87. Tan, Y. F.; Li, F. X.; Piao, Y. S.; Sun, X. Y.; Wang, Y. L. Global gene profiling analysis of mouse uterus during the oestrous cycle. Reproduction 126(2):171-182; 2003.
88. Tarcsa, E.; Candi, E.; Kartasova, T.; Idler, W. W.; Marekov, L. N.; Steinert, P. M. Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins. J. Biol. Chem. 273(36):23297-23303; 1998.
89. Taupin, D.; Podolsky, D. K. Trefoil factors: Initiators of mucosal healing. Nat. Rev. Mol. Cell. Biol. 4(9):721-732; 2003.
90. Tebbutt, N. C.; Giraud, A. S.; Inglese, M.; Jenkins, B.; Waring, P.; Clay, F. J.; Malki, S.; Alderman, B. M.; Grail, D.; Hollande, F.; Heath, J. K.; Ernst, M. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8(10):1089-1097; 2002.
91. Teoh, N. C.; Farrell, G. C. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J. Gastroenterol. Hepatol. 18(8):891-902; 2003.
92. Tesfaigzi, J.; Carlson, D. M. Cell cycle-specific expression of G(0)SPR1 in Chinese hamster ovary cells. Exp. Cell Res. 228(2):277-282; 1996.
93. Testa, G.; Malago, M.; Broelseh, C. E. Complications of biliary tract in liver transplantation. World J. Surg. 25(10):1296-1299; 2001.
94. Tillmann, H. L.; Manns, M. P.; Rudolph, K. L. Merging models of hepatitis C virus pathogenesis. Semin. Liver Dis. 25(1):84-92; 2005.
95. Todo, S.; Demetris, A. J.; Makowka, L.; Teperman, L.; Podesta, L.; Shaver, T.; Tzakis, A.; Starzl, T. E. Primary nonfunction of hepatic allografts with preexisting fatty infiltration. Transplantation 47(5):903-905; 1989.
96. Tolba, R. H.; Yonezawa, K.; Song, S.; Burger, C.; Minor, T. Synergistic value of fibrinolysis and hypothermic aerobic preservation with oxygen in the protection of livers from non-heart-beating donors: An experimental model. Transplant. Proc. 36(10):2927-2930; 2004.
97. Tomasetto, C.; Masson, R.; Linares, J. L.; Wendling, C.; Lefebvre, O.; Chenard, M. P.; Rio, M. C. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology 118(1):70-80; 2000.
98. Tomasetto, C.; Rio, M. C.; Gautier, C.; Wolf, C.; Hareuveni, M.; Chambon, P.; Lathe, R. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 9(2): 407-414; 1990.
99. Wanless, I. Physioanatomic considerations. In: Schiff, E. R.; Sorrell, M. F.; Maddrey, W. E., eds. Schiffs diseases of the liver, 8th ed. Philadelphia: Lippincott Williams & Wilkins; 1999:3-37.
100. Watanabe, S.; Matsuda, A.; Suzuki, Y.; Kondo, K.; Ikeda, Y.; Hashimoto, H.; Umemura, K. Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors. Br. J. Pharmacol. 130(2):307-314; 2000.
101. Wengrower, D.; Zannineli, G.; Pappo, O.; Latella, G.; Sestieri, M.; Villanova, A.; Faitelson, Y.; Pines, M.; Goldin, E. Prevention of fibrosis in experimental colitis by captopril: The role of tgf-beta1. Inflamm. Bowel Dis. 10(5):536-545; 2004.
102. Yamauchi, J. I.; Richter, S.; Vollmar, B.; Menger, M. D.; Minor, T. Warm preflush with streptokinase improves microvascular procurement and tissue integrity in liver graft retrieval from non-heart-beating donors. Transplantation 69(9):1780-1784; 2000.
103. Yasoshima, M.; Kono, N.; Sugawara, H.; Katayanagi, K.; Harada, K.; Nakanuma, Y. Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study. Lab. Invest. 78(1):89-100; 1998.
104. Yuan, G. J.; Zhang, M. L.; Gong, Z. J. Effects of PPARg agonist pioglitazone on rat hepatic fibrosis. World J. Gastroenterol. 10(7):1047-1051; 2004.