The genetic stability of a conditional live HIV-1 variant can be improved by mutations in the tet-on regulatory system that restrain evolution

Journal of Biological Chemistry

Volumn 281, Issue 25, 2006, Pages 17084-17091

  Zhou, Xue ^a   Vink, Monique ^a   Klaver, Bep ^a   Verhoef, Koen ^a   Marzio, Giuseppe ^a   Das, Atze T ^a   Berkhout, Ben ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BATCH CELL CULTURE; BIOCOMPATIBILITY; DISEASE CONTROL; GENES; GENETIC ENGINEERING; SUBSTITUTION REACTIONS; VACCINES;

HUMAN IMMUNODEFICIENCY VIRUS; PATHOGENIC VIRUS VARIANTS; REPLICATIONS; TETRACYCLINE-INDUCIBLE GENE EXPRESSION SYSTEM;

VIRUSES;

AMINO ACID; DOXYCYCLINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE; TRANSACTIVATOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; FEMALE; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION SYSTEM; GENETIC ENGINEERING; GENETIC STABILITY; GENETIC VARIABILITY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR EVOLUTION; PRIORITY JOURNAL; VIRUS CULTURE; VIRUS MUTATION; VIRUS REPLICATION;

AIDS VACCINES; CODON; DOXYCYCLINE; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; TETRACYCLINE; VACCINES, ATTENUATED; VARIATION (GENETICS); VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33745190519     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513400200     Document Type: Article

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