Crosstalk between PDGF and IGF-I receptors in rat liver myofibroblasts: Implication for liver fibrogenesis

Laboratory Investigation

Volumn 86, Issue 7, 2006, Pages 710-723

  Novosyadlyy, Ruslan ^a,c   Dudas, Jozsef ^a   Pannem, Rajeswararao ^a   Ramadori, Giuliano ^a   Scharf, Jens Gerd ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Crosstalk; IGF; Liver fibrogenesis; PDGF; Receptors

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA1; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; RECEPTOR SUBUNIT; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MITOGENESIS; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STELLATE CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; LIVER; LIVER CIRRHOSIS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTOR CROSS-TALK; RECEPTOR, IGF TYPE 1; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR;

EID: 33745151434     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700426     Document Type: Article

References (49)

1. Ramadori G, Saile B. Portal tract fibrogenesis in the liver. Lab Invest 2004;84:153-159.
2. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-218.
3. Knittel T, Kobold D, Saile B, et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999;117:1205-1221.
4. Knittel T, Kobold D, Piscaglia F, et al. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-) fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 1999;112:387-401.
5. Cassiman D, Libbrecht L, Desmet V, et al. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 2002;36:200-209.
6. Pinzani M, Rombouts K. Liver fibrosis: from the bench to clinical targets. Dig Liver Dis 2004;36:231-242.
7. Novosyadlyy R, Tron K, Dudas J, et al. Expression and regulation of the insulin-like growth factor axis components in rat liver myofibroblasts. J Cell Physiol 2004;199:388-398.
8. Saile B, DiRocco P, Dudas J, et al. IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF). Lab Invest 2004;84:1037-1049.
9. LeRoith D, Werner H, Beitner-Johnson D, et al. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995;16:143-163.
10. Rubin R, Baserga R. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Lab Invest 1995;73:311-331.
11. Clemmons DR, Shaw DS. Variables controlling somatomedin production by cultured human fibroblasts. J Cell Physiol 1983;115:137-142.
12. Clemmons DR. Multiple hormones stimulate the production of somatomedin by cultured human fibroblasts. J Clin Endocrinol Metab 1984;58:850-856.
13. Rubini M, Werner H, Gandini E, et al. Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene. Exp Cell Res 1994;211:374-379.
14. DeAngelis T, Ferber A, Baserga R. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J Cell Physiol 1995;164:214-221.
15. Heldin CH, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998;1378:F79-F113.
16. Lee KH, Bowen-Pope DF, Reed RR. Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium. Mol Cell Biol 1990;10:2237-2246.
17. Herren B, Weyer KA, Rouge M, et al. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Biochim Biophys Acta 1993;1173:294-302.
18. Seglen PO. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 1973;82:391-398.
19. Scharf J, Ramadori G, Braulke T, et al. Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: regulation by insulin, insulinlike growth factor, and growth hormone. Hepatology 1996;23:818-827.
20. Hartmann H, Schmitz F, Christ B, et al. Metabolic actions of insulin-like growth factor-I in cultured hepatocytes from adult rats. Hepatology 1990;12:1139-1143.
21. Knook DL, Sleyster EC. Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation. Exp Cell Res 1976;99:444-449.
22. Knittel T, Janneck T, Muller L, et al. Transforming growth factor beta 1-regulated gene expression of Ito cells. Hepatology 1996;24:352-360.
23. Chirgwin JM, Przybyla AE, MacDonald RJ, et al. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979;18:5294-5299.
24. Caufriez A, Reding P, Urbain D, et al. Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. J Endocrinol Invest 1991;14:317-321.
25. Hattori N, Kurahachi H, Ikekubo K, et al. Serum growth hormone-binding protein, insulin-like growth factor-I, and growth hormone in patients with liver cirrhosis. Metabolism 1992;41:377-381.
26. Buzzelli G, Dattolo P, Pinzani M, et al. Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without super-imposed hepatocarcinoma: evidence of an altered circadian rhythm. Am J Gastroenterol 1993;88:1744-1748.
27. Moller S, Gronbaek M, Main K, et al. Urinary growth hormone (U-GH) excretion and serum insulin-like growth factor 1 (IGF-1) in patients with alcoholic cirrhosis. J Hepatol 1993;17:315-320.
28. Scharf JG, Schmitz F, Frystyk J, et al. Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease. J Hepatol 1996;25:689-699.
29. Pinzani M, Milani S, Herbst H, et al. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 1996;148:785-800.
30. Zhang BB, Cai WM, Weng HL, et al. Diagnostic value of platelet derived growth factor-BB, transforming growth factor-betal, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis. World J Gastroenterol 2003;9:2490-2496.
31. Clemmons DR. Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells. Circ Res 1985;56:418-426.
32. Pinzani M, Abboud HE, Aron DC. Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: regulatory role of platelet-derived growth factor. Endocrinology 1990;127:2343-2349.
33. Delafontaine P, Lou H, Alexander RW. Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells. Hypertension 1991;18:742-747.
34. Rosenfeld RG, Dollar LA. Characterization of the somatomedin-C/insulin- like growth factor I (SM-C/IGF-I) receptor on cultured human fibroblast monolayers: regulation of receptor concentrations by SM-C/IGF-I and insulin. J Clin Endocrinol Metab 1982;55:434-440.
35. Conover CA, Powell DR. Insulin-like growth factor (IGF)-binding protein-3 blocks IGF-I-induced receptor down-regulation and cell desensitization in cultured bovine fibroblasts. Endocrinology 1991;129:710-716.
36. Eshet R, Klinger B, Silbergeld A, et al. Modulation of insulin like growth factor I (IGF-I) binding sites on erythrocytes by IGF-I treatment in patients with Laron syndrome (LS). Regul Pept 1993;48:233-239.
37. Hernandez-Sanchez C, Werner H, Roberts Jr CT, et al. Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. J Biol Chem 1997;272:4663-4670.
38. Bostedt KT, Schmid C, Ghirlanda-Keller C, et al. Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells. Exp Cell Res 2001;271:368-377.
39. Lee AV, Gooch JL, Oesterreich S, et al. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3′-kinase inhibition. Mol Cell Biol 2000;20:1489-1496.
40. Karenberg TA, Fenn A, Sachinidis A, et al. The differential activation of phosphatidylinositol-3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two growth factors on the proliferation of AKR-2B fibroblasts. Exp Cell Res 1994;213:266-274.
41. Thommes KB, Hoppe J, Vetter H, et al. The synergistic effect of PDGF-AA and IGF-1 on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways. Exp Cell Res 1996;226:59-66.
42. Pearson G, Robinson F, Beers GT, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001;22:153-183.
43. Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 1999;79:143-180.
44. Skrtic S, Wallenius K, Gressner AM, et al. Insulin-like growth factor signaling pathways in rat hepatic stellate cells: importance for deoxyribonucleic acid synthesis and hepatocyte growth factor production. Endocrinology 1999;140:5729-5735.
45. Svegliati-Baroni G, Ridolfi F, Di SA, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology 1999;29:1743-1751.
46. Gentilini A, Marra F, Gentilini P, et al. Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells. J Hepatol 2000;32:227-234.
47. Pinzani M. PDGF and signal transduction in hepatic stellate cells. Front Biosci 2002;7:d1720-d1726.
48. Rebecchi MJ, Pentyala SN. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 2000;80:1291-1335.
49. Dalle S, Ricketts W, Imamura T, et al. Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem 2001;276:15688-15695.