Mechanisms of action and targets for actual and future antiplatelet drugs

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 6, 2006, Pages 719-726

  Freson, Kathleen ^a   Thys, Chantal ^a   Wittevrongel, Christine ^a   Van Geet, Chris ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cyclooxygenase; GPIIb IIIa antagonists; Monoclonal antibody; Thrombin Receptors; Ticlopidine

Indexed keywords

3 (4 CHLOROPHENYL) 2 (2,4 DICHLOROBENZOYLIMINO) 5 (METHOXYCARBONYLMETHYLENE) 1,3 THIAZOLIDIN 4 ONE; 5 (2 CHLOROBENZYL) 5,6,7,7A TETRAHYDRO 4H THIENO[3,2 C]PYRIDIN 2 ONE; ABCIXIMAB; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; AR 545C; BETA1 INTEGRIN; C 186 65; CLOPIDOGREL; COLLAGEN RECEPTOR; DRUG METABOLITE; EPTIFIBATIDE; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; FR 171113; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE[6-38]; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6B4; MONOCLONAL ANTIBODY JAQ1; PEPTIDE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; SALICYLIC ACID DERIVATIVE; THROMBIN RECEPTOR; TICLOPIDINE; TIROFIBAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALYLCYSTEINYLLEUCINE;

APLASTIC ANEMIA; ARTERY THROMBOSIS; ATHEROSCLEROSIS; BLEEDING TENDENCY; CLINICAL PRACTICE; CLINICAL TRIAL; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG USE; ENTERIC COATED TABLET; FUTUROLOGY; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; NEUTROPENIA; NONHUMAN; PRIMARY PREVENTION; REVIEW; SECONDARY PREVENTION; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ASPIRIN; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; HUMANS; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEIN IIB; PYRIDINES; RECEPTORS, PURINERGIC;

EID: 33745115613     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706777435661     Document Type: Review

References (76)

1. Kulkarni, S.; Dopheide, S.M.; Yap, C.L.; Ravanat, C.; Freund, M.; Mangin, P.; Heel, K.A.; Street, A.; Harper, I.S.; Lanza, F.; Jackson, S.P. J. Clin. Invest., 2000, 105, 783.
2. Fitzgerald, D.J.; Roy, L.; Catella, F.; FitzGerald, G.A. N. Engl. J. Med. 1986, 315, 983.
3. Schafer, A.; Eigenthaler, M.; Bauersachs, J. Clin. Lab., 2004, 50, 559.
4. Freson, K.; Hashimoto, H.; Thys, C.; Wittevrongel, C.; Danloy, S.; Morita, Y.; Shintani, N.; Tomiyama, Y.; Vermylen, J.; Hoylaerts, M.F.; Baba, A.; Van Geet, C. J. Clin. Invest., 2004, 113, 905.
5. Roth, G.J.; Majerus, P.W. J. Clin. Invest. 1975, 56, 624.
6. Burch, J.W.; Stanford, N.; Majerus, P.W. J. Clin. Invest., 1978, 61, 314.
7. Antithrombotic Trialists' Collaboration. BMJ., 2002, 324, 71.
8. Hennekens, C.H. Am. J. Manag. Care., 2002, 8, S691.
9. Smith, W.L.; Am. J. Physiol., 1992, 263, F181.
10. Smith, W.L.; DeWitt, D.L.; Garavito, R.M. Annu. Rev. Biochem., 2000, 69, 145.
11. Loll, P.J.; Picot, D.; Garavito, R.M. Nat. Struct. Biol., 1995, 2, 637.
12. Rinder, C.S.; Student, L.A.; Bonan, J.L.,; Rinder, H.M.; Smith, B.R. Blood, 1993, 82, 505.
13. Lewis, H.D. Jr.; Davis, J.W.; Archibald, D.G.; Steinke, W.E.; Smitherman, T.C.; Doherty, J.E. 3rd.; Schnaper, H.W.; LeWinter, M.M.; Linares, E.; Pouget, J.M.; Sabharwal, S.C.; Chesler, E.; DeMots, H. N. Engl. J. Med., 1983, 309, 396.
14. de Gaetano, G. Lancet, 2001, 357, 89.
15. Burch, J.W.; Stanford, N.; Majerus, P.W. J. Clin. Invest., 1978, 61, 314.
16. Pedersen, A.K.; FitzGerald, G.A. N. Engl. J. Med., 1984, 311, 1206.
17. Patrono, C.; Coller, B.; Dalen, J.E.; Fuster, V.; Gent, M.; Harker, L.A.; Hirsh, J.; Roth, G. Chest, 1998, 114, 470S.
18. Gum, P.A.; Kottke-Marchant, K.; Poggio, E.D.; Gurm, H.; Welsh, P.A.; Brooks, L.; Sapp, S.K.; Topol, E.J. Am. J. Cardiol., 2001, 88, 230.
19. Eikelboom, J.W.; Hirsh, J.; Weitz, J.I.; Johnston, M.; Yi, Q.; Yusuf, S. Circulation, 2002, 105, 1650.
20. Buchanan, M.R.; Brister, S.J. Can. J. Cardiol., 1995, 11, 221.
21. Grotemeyer, K.H.; Scharafinski, H.W.; Husstedt, I.W. Thromb. Res., 1993, 71, 397.
22. Michelson, A.D.; Barnard, M.R.; Krueger, L.A.; Valeri, C.R,: Furman, M.I. Circulation, 2001, 104, 1533.
23. Rao, G.H.; Johnson, G.G.; Reddy, K.R.; White, J.G. Arteriosclerosis, 1983, 3, 383.
24. Catella-Lawson, F.; Reilly, M.P.; Kapoor, S.C.; Cucchiara, A.J.; DeMarco, S.; Tournier, B.; Vyas, S.N.; FitzGerald, G.A. N. Engl. J. Med., 2001, 345, 1809.
25. Ray, W.A.; Stein, C.M.; Hall, K.; Daugherty, J.R.; Griffin, M.R. Lancet, 2002, 359, 118.
26. Quinn, M.J.; Fitzgerald, D.J. Circulation, 1999, 100, 1667.
27. Savi, P.; Herbert, J.M. Semin. Thromb. Hemost., 2005, 31, 174.
28. Pereillo, J.M.; Maftouh, M.; Andrieu, A.; Uzabiaga, M.F.; Fedeli, O.; Savi, P.; Pascal, M.; Herbert, J.M.: Maffrand, J.P.; Picard, C. Drug Metab. Dispos., 2002, 30, 1288.
29. Gachet, C. Thromb. Haemost., 2001, 86, 222.
30. Renner, C.; Guilmet, D.; Curtet, J.M. Nouv. Presse Med., 1980, 9, 3249.
31. Herbert, J.M.; Tissinier, A.; Defreyn, G.; Maffrand, J.P. Arterioscler. Thromb., 1993, 13, 1171.
32. Bennett, C.L.; Connors, J.M.; Carwile, J.M.; Moake, J.L.; Bell, W.R.; Tarantolo, S.R.; McCarthy, L.J.; Sarode, R.; Hatfield, A.J.; Feldman, M.D.; Davidson, C.J.; Tsai, H.M. N. Enql. J. Med., 2000, 342, 1773.
33. Vincent, J.F.; Zijlstra, F.J.; de Wit, C.M.; Bonta I.L. Prostaglandins Leukot. Med., 1984, 16, 279.
34. Savi, P.; Combalbert, J.; Gaich, C.: Rouchon, M.C.; Maffrand, J.P.; Berger, Y.; Herbert, J.M. Thromb. Haemost., 1994, 72. 313.
35. Savi, P.; Pereillo, J.M.; Uzabiaga, M.F.; Combalbert, J.; Picard, C.; Maffrand, J.P.; Pascal, M., Herbert, J.M. Thromb. Haemost., 2000, 84, 891.
36. Steinhubl, S.R.; Berger, P.B.; Mann, J.T. 3rd; Fry, E.T.; DeLago, A.; Wilmer, C.; Topol, E.J. JAMA. 2002, 288, 2411.
37. Gent, M.; Blakely, J.A.; Easton, J.D.; Ellis, D.J.; Hachinski, V.C.; Harbison, J.W.; Panak, E.; Roberts, R.S.; Sicurella, J.; Turpie, A.G. Lancet, 1989, 1, 1215.
38. Hass, W.K.; Easton, J.D.; Adams, H.P. Jr.; Pryse-Phillips. W.; Molony, B.A.; Anderson, S.; Kamm, B. N. Engl. J. Med., 1989, 321, 501.
39. Balsano, F, Rizzon, P.; Violi, F.; Scrutinio, D.; Cimminiello, C.; Aguglia, F.; Pasotti C.; Rudelli, G. Circulation, 1990, 82, 17.
40. CAPRIE Steering Committee. Lancet, 1996, 348, 1329.
41. Yusuf, S.; Zhao, F.; Mehta, S.R.; Chrolavicius, S.; Tognoni, G.; Fox, K.K. N. Engl. J. Med., 2001, 345, 494.
42. Mehta, S.R.; Yusuf, S.; Peters, R.J.; Bertrand, M.E.; Lewis, B.S.; Natarajan, M.K.; Malmberg, K.; Rupprecht, H.; Zhao, F.; Chrolavicius, S.; Copland, I.; Fox, K.A.; Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Lancet, 2001, 358, 527.
43. Steinhubl, S.R.; Berger, P.B.; Mann, J.T. 3rd; Fry, E.T.; DeLago, A.; Wilmer, C.; Topol, E.J. JAMA, 2002, 288, 2411.
44. Savage, B.; Ruggeri, Z.M. J. Biol. Chem., 1991, 266, 11227.
45. Naik, U.P.; Patel, P.M.; Parise, L.V. J. Biol. Chem., 1997, 272, 4651.
46. Clemetson, K.J. Thromb. Haemost., 1995, 74, 111.
47. Coller, B.S. J. Clin. Invest., 1997, 100, S57.
48. Plescia, J.; Conte, M.S.; VanMeter, G.; Ambrosini, G.; Altieri, D.C. J. Biol. Chem., 1998, 273, 20372.
49. Lynch, J.J. Jr; Cook, J.J.; Sitko, G.R.; Holahan, M.A.: Ramjit, D.R.; Mellott, M.J.; Stranieri, M.T.; Stabilito, I.I.; Zhang, G.; Lynch, R.J. J. Pharmacol. Exp. Ther., 1995, 272, 20.
50. Scarborough, R.M.; Naughton, M.A.; Teng, W.; Rose, J.W.; Phillips, D.R.; Nannizzi, L.; Arfsten, A.; Campbell, A.M.; Charo, I.F. J. Biol. Chem., 1993, 268, 1066.
51. Quinn, M.J.; Plow, E.F.; Topol, E.J. Circulation, 2002, 106, 379.
52. Gold, H.K.; Gimple, L.W.; Yasuda, T.; Leinbach, R.C.; Werner, W.; Holt, R.; Jordan, R.; Berger, H.; Collen, D.; Coller, B.S. J. Clin. Invest., 1990, 86, 651.
53. Lincoff, A.M.; Califf, R.M.; Moliterno, D.J.; Ellis, S.G.; Ducas, J.; Kramer, J.H.; Kleiman, N.S.; Cohen, E.A.; Booth, J.E.; Sapp, S.K.; Cabot, C.F.; Topol, E.J. N. Engl. J. Med., 1999, 341, 319.
54. Moliterno, D.J.; Yakubov, S.J.; DiBattiste, P.M.; Herrmann, H.C.; Stone, G.W.; Macaya, C.; Neumann, F.J.; Ardissino, D.; Bassand, J.P.; Borzi, L.; Yeung, A.C.; Harris, K.A.; Demopoulos, L.A.; Topol, E.J. Lancet, 2002, 360, 355.
55. Boersma, E.; Harrington, R.A.; Moliterno, D.J.; White, H.; Theroux, P.; Van de Werf, F.; de Torbal, A.; Armstrong, P.W.; Wallentin, L.C.; Wilcox, R.G.; Simes, J.; Califf, R.M.; Topol, E.J.; Simoons, M.L. Lancet, 2002, 359, 189.
56. Simoons, M.L. Lancet, 2001, 357, 1915.
57. Cauwenberghs, N.; Meiring, M.; Vauterin, S.; van Wyk. V.; Lamprecht, S.; Roodt, J.P.; Novak, L.; Harsfalvi, J.; Deckmyn, H.; Kotze, H.F. Arterioscler. Thromb. Vasc. Biol., 2000, 20, 1347.
58. Kageyama, S.; Yamamoto, H.; Yoshimoto, R. Arterioscler. Thromb. Vasc. Biol., 2000, 20, 2303.
59. Gralnick, H.R.; Williams, S.; McKeown, L.; Kramer, W.; Krutzsch, H.; Gorecki, M.; Pinet, A.; Garfinkel, L.I. Proc. Natl. Acad. Sci. USA, 1992, 89, 7880.
60. Gurevitz, O.; Goldfarb, A.; Hod, H.; Feldman, M.; Shenkman, B.; Varon, D.; Eldar, M.; Inbal, A. Arterioscler. Thromb. Vasc. Biol., 1998, 18, 200.
61. McGhie, A.I.; McNatt, J.; Ezov, N.; Cui, K.; Mower, L.K.; Hagay, Y.; Buja, L.M.; Garfinkel, L.I.; Gorecki, M.; Willerson, J.T. Circulation, 1994, 90, 2976.
62. Azzam, K.; Garfinkel, L.I.; Bal dit Sollier, C.; Cisse Thiam, M.; Drouet, L. Thromb. Haemost., 1995, 73, 318.
63. Coughlin, S.R. J. Thromb. Haemost., 2005, 3, 1800.
64. Klement, P.; Borm, A.; Hirsh, J.; Maraganore, J.; Wilson, G.; Weitz, J. Thromb. Haemost., 1992, 68, 64.
65. Cook, J.J.; Sitko, G.R.; Bednar, B.; Condra, C.; Mellott, M.J.; Feng, D.M.; Nutt, R.F.; Shafer, J.A.; Gould, R.J.; Connolly, T.M. Circulation. 1995, 91, 2961.
66. Scarborough, R.M. Circulation, 1992, 86(Suppl. 1), 1.
67. Kato, Y.; Kita, Y.; Nishio, M.; Hirasawa, Y.; Ito, K.; Yamanaka, T.; Motoyama, Y.; Seki, J. Eur. J. Pharmacol., 1999, 384, 197.
68. Watson, S.P. Thromb. Haemost., 1999, 82, 365.
69. Emsley, J.; Knight, C.G.; Farndale, R.W.; Barnes, M.J.; Liddington, R.C. Cell, 2000, 101, 47.
70. Goto, S.; Tamura, N.; Handa, S.; Arai, M.; Kodama, K.; Takayama, H. Circulation, 2002, 106, 266.
71. Nieswandt, B.; Schulte, V.; Bergmeier, W.; Mokhtari-Nejad, R.; Rackebrandt, K.; Cazenave, J.P.; Ohlmann, P.; Gachet, C.; Zirngibl, H. J. Exp. Med., 2001, 193, 459.
72. Marcus, A.J.: Broekman, M.J.; Drosopoulos, J.H.; Islam, N.; Alyonycheva, T.N.; Safier, L.B.; Hajjar, K.A.; Posnett, D.N.; Schoenborn, M.A.; Schooley, K.A.; Gayle, R.B.; Maliszewski, C.R. J. Clin. Invest., 1997, 99, 1351.
73. Enjyoji, K.; Sevigny, J.; Lin, Y.; Frenette, P.S.; Christie, P.D.; Esch, J.S. 2nd.; Imai, M.; Edelberg, J.M.; Rayburn, H.; Lech, M.; Beeler, D.L.; Csizmadia, E.; Wagner, D.D.; Robson, S.C.; Rosenberg, R.D. Nat. Med., 1999, 5, 1010.
74. Marcus, A.J.: Broekman, M.J.; Drosopoulos, J.H.; Olson, K.E.; Islam, N.; Pinsky, D.J.; Levi, R. Semin. Thromb. Hemost., 2005, 31, 234.
75. Hosoya, M.; Kimura, C.; Ogi, K.; Ohkubo, S.: Miyamoto, Y.: Kugoh, H.; Shimizu, M.; Onda, H.; Oshimura, M.; Arimura, A. Biochim. Biophys. Acta, 1992, 1129, 199.
76. Vaudry, D.; Gonzalez, B.J.; Basille, M.; Yon, L.; Fournier, A.; Vaudry, H. Pharmacol. Rev., 2000, 52, 269.