Mechanisms of UV-induced signal transduction

Journal of Dermatology

Volumn 29, Issue 4, 2002, Pages 189-196

  Kulms, Dagmar ^a   Schwarz, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

DNA damage; Receptor activation; Signal transduction reactive oxygen species; UV radiation

Indexed keywords

CELL SURFACE RECEPTOR; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

CELL MEMBRANE; CHROMATOPHORE; CYTOPLASM; DNA DAMAGE; HUMAN; RADIATION INJURY; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; ULTRAVIOLET B RADIATION;

EID: 0036251498     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2002.tb00248.x     Document Type: Review

References (49)

1. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice
2. Mechanisms involved in ultraviolet light-induced immunosuppression
3. Pathophysiology of premature skin aging induced by ultraviolet light
4. Ultraviolet-B-induced apoptosis and cytokine release in xeroderma pigmentosum keratinocytes
5. Studies on thymine-derived UV photoproducts in DNA-I. Formation and biological role of pyrimidine adducts in DNA
6. Sunlight and skin cancer: Another link revealed
7. Evidence that DNA damage is a mediate in ultraviolet B radiation-induced inhibition of human gene expression: Ultraviolet B radiation effects on intercellular adhesion molecule-1 (ICAM-1) expression
8. Localization of liposomes containing DNA repair enzyme in murine skin
9. Pyrimidine Dimers in DNA initiate systemic immunosuppression in UV-irradiated mice
10. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes
11. Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin10 and tumor necrosis factor-alpha
12. UV-DNA damage in mouse and human cells induces the expression of tumor necrosis factor alpha
13. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
14. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice
15. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: A randomised study
16. The molecular determinants of sunburn cell formation
17. Sunburn and p53 in the onest of skin cancer
18. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion
19. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma
20. Nuclear and membrane effects contribute independently to the induction of apoptosis in human cells exposed to ultraviolet B radiation
21. Frequent clones of p53 mutated keratinocytes in normal human skin
22. Death receptors: Signaling and modulation
23. Mechanisms of CD95 (APO-1/Fas) -mediated apoptosis
24. Ultraviolet light induces apoptosis via direct activation of CD95 (FAS/APO-1) independently from its natural ligand CD95L
25. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO1)
26. Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
27. Ultraviolet radiation-induced interleukin 6 release in HeLa cells is mediated via membrane events in a DNA damage independent way
28. NFkB activation by ultraviolet light not dependent on a nuclear signal
29. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
30. UVB light induces nuclear factor KB activity independent from chromosomal DNA damage in cell-free cytosolic extracts
31. Involvement of growth factor receptors in the mammalian UVC response
32. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants of alkylating agents
33. Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction
34. Ultraviolet A radiation-induced expression of human genes: Molecular and pathobiological mechanisms
35. H202 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes
36. Peroxidation of linoleic, arachidonic, and oleic acid in relation to the induction of oxidative DNA damage and cytogenic effects
37. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
38. Molecular mechanisms of UV-induced apoptosis
39. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-9
40. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
41. Ultraviolet light induces increased circulating interleukin 6 in humans
42. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
43. Regulation of STAT-dependent pathways by growth factors and cytokines
44. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
45. Ultraviolet light suppresses IFN-g-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factors
46. Downregulation of interferon-γ-activated STAT 1 by ultraviolet light
47. Regulation of cell growth by IL-2: Role of STAT 5 in protection from apoptosis but not in cell cycle progression
48. Not just another meeting: The coming age of JAKs and STATs
49. Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes