Detection of alkylation damage in human lymphocyte DNA with the comet assay

Acta Biochimica Polonica

Volumn 48, Issue 3, 2001, Pages 611-614

  Collins, Andrew R ^a   Dušinská, Mária ^a,b   Horská, Alexandra ^a,b  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

Author keywords

AlkA; Comet assay; DNA damage

Indexed keywords

DNA 3 METHYLADENINE GLYCOSIDASE II; DNA GLYCOSYLTRANSFERASE; DNA-3-METHYLADENINE GLYCOSIDASE II; GLYCOSIDASE; MESYLIC ACID METHYL ESTER;

ALKYLATION; ARTICLE; COMET ASSAY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; HUMAN; LYMPHOCYTE; METABOLISM; METHODOLOGY; TIME;

ALKYLATION; COMET ASSAY; DNA DAMAGE; DNA GLYCOSYLASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LYMPHOCYTES; METHYL METHANESULFONATE; N-GLYCOSYL HYDROLASES; TIME FACTORS;

EID: 0035753180     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2001_3895     Document Type: Article

References (8)

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6. Dušinská, M. & Collins, A. (1996) Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. Altern. Lab. Anim. 24, 405-411.
7. Dušinská, M., Lietava, J., Olmedilla, B., Rašlová, K., Southon, S. & Collins, A.R. (1999) Indicators of oxidative stress, antioxidants and human health; in Antioxidants in Human Health (Basu, T.K., Temple, N.J. & Garg, M.L., eds.) pp. 411-422, CABI Publishing, Oxford, U.K.
8. Lindahl, T. (1993) Instability and decay of the primary structure of DNA. Nature 362, 709-715.