5-HT(1A) receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus

European Journal of Pharmacology

Volumn 317, Issue 1, 1996, Pages 49-54

  Matos, F Fátima ^a   Korpinen, Carolyn ^a   Yocca, Frank D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT(1A) receptor; BMY 14802; Dorsal raphe; Hippocampus; Microdialysis

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; FLUOXETINE; HOMOVANILLIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN; SEROTONIN 1A RECEPTOR; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINE BUTANOL; ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINE BUTANOL; ANXIOLYTIC AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DORSAL RAPHE NUCLEUS; HIPPOCAMPUS; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-ANXIETY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; MALE; MICRODIALYSIS; PIPERAZINES; PYRIDINES; PYRIMIDINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030581704     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00699-1     Document Type: Article

References (30)

1. Baraban, J.M. and G.K. Aghajanian, 1981, Noradrenergic innervation of serotonergic neurons in the dorsal raphe: Demonstration by electron microscopic autoradiograph, Brain Res. 204, 1.
2. 1A agonist gepirone: Electrophysiological studies in the rat brain, Synapse 1, 470.
3. 1A receptor, Eur. J. Pharmacol. 204, 21.
4. Cimino, M., F. Ponzio, G. Achilli, G. Vantini, C. Perego, S. Algeri and S. Garattini, 1983, Dopaminergic effects of buspirone, a novel anxiolytic agent, Biochem. Pharmacol. 32, 1069.
5. Descarries, L., K.C. Watkins, S. Garcia and A. Beaudet, 1982, The serotonin neurons in nucleus raphe dorsalis of adult rat: A light and electron microscope radioautographic study, J. Comp. Neurol. 207, 239.
6. 2 receptors: Microdialysis studies in the awake and anaesthetized rat, Neuropharmacology 33, 411.
7. 1A receptor antagonist, Br. J. Pharmacol. 112, 91P.
8. 1A receptor antagonist WAY-100635 on hippocampal 5-HT release in vivo, Br. J. Pharmacol. 112, 299P.
9. 1A autoreceptors and α1 -adrenoceptors in the inhibition of 5-HT release-I. BMY-7378 and prazosin, Neuropharmacology 34, 615.
10. 1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-) penbutolol, J. Pharmacol. Exp. Ther. 265, 707.
11. Matos, F.F., C. Urban and F.D. Yocca, 1996, Serotonin (5-HT) release in the dorsal raphe and ventral hippocampus: Raphe control of somatodendritic and terminal 5-HT release, J. Neural Transm. 103, 173.
12. Matthews, R.T., B.A. McMillen, R. Sallis and D. Blair, 1986, Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function, J. Pharmacol. Exp. Therap. 239, 124.
13. McMillen, B.A., R.T. Matthews, M.K. Sanghera, P.D. Shepard and D.C. German, 1983, Dopamine receptor antagonism by the novel antianxiety drug, buspirone, J. Neurosci. 3, 733.
14. 1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus, Eur. J. Pharmacol. 216, 373.
15. Paxinos, G. and C. Watson, 1986, The Rat Brain in Stereotaxic Coordinates (Academic Press, Orlando, FL).
16. Pecci-Saavedra, J., A. Brusco, S. Peressini, D. Olivia, 1986, A new case for a presynaptic role of dendrites: An immunocytochemical study of the N. raphe dorsalis, Neurochem. Res. 11, 997.
17. Rao, T.S., J.A. Cler, E.J. Oei, S. Iyengar and P.L. Wood, 1990, Increased release of dopamine in vivo by BMY 14802: Contrasting pattern to clozapine, Neuropharmacology 29, 503.
18. 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis, Br. J. Pharmacol. 96, 283.
19. Sharp, T., S.R. Bramwell, S. Hjorth and D.G. Grahame-Smith, 1989b, Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis, Br. J. Pharmacol. 98, 989.
20. 1A-mediated anxiolytic activity, Soc. Neurosci, Abstr. 18, 1382.
21. 1B agonists, Synapse 1, 3.
22. Taylor, D. and J. Dekleva, 1988, A potential antipsychotic agent that selectively binds to σ receptors, in: Sigma and Phencyclidine-like compounds as molecular probes in Biology, eds. E.F. Domino and J.-M. Kamenka (NPP Books, Ann Arbor, MI) p. 345.
23. Taylor, D., M.S. Eison, S.L. Moon and F.D. Yocca, 1991, A potential antipsychotic with selective affinity for σ-binding sites, Adv. Neuropsychiatry Psychopharmacol. 1, 307.
24. Terleckyj, I. and P.K. Sonsalla, 1994, The σ receptor ligand (±)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors, J. Pharmacol. Exp. Therap. 269. 44.
25. Vahabzadeh, A. and M. Fillenz, 1992, Studies on the origen of rat hippocampal dihydroxyphenylacetic acid using microdialysis, Neurosci. Lett. 136, 51.
26. VanderMaelen, C.P., G.K. Matheson, R.C. Wilderman and L.A. Patterson, 1986, Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug, Eur. J. Pharmacol. 129, 123.
27. VanderMaelen, C.P. and J.P. Braselton, 1990, Effects of a potential antipsychotic, BMY-14802, on firing of central serotonergic and noradrenergic neurons in rats, Eur. J. Pharmacol. 179, 357.
28. Wachtel, S.R. and F.J. White, 1988, Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopaminergic neurons in the rat: Acute and chronic studies, J. Pharmacol. Exp. Ther. 244, 410.
29. Zetterström, T., T. Sharp and U. Ungerstedt, 1985, Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis, Eur. J. Pharmacol. 106, 27.
30. Zhang, J., L.A. Chiodo and A.S. Freeman, 1993, Further characterization of the effects of BMY 14802 on dopamine neuronal activity, Synapse 15, 276.