Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function

Cerebellum

Volumn 4, Issue 3, 2005, Pages 154-161

  Llansola, Marta ^a   Sanchez Perez, Ana ^a   Cauli, Omar ^a   Felipo, Vicente ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Alternative splicing; NMDA receptors; Pharmacology; Phosphorylation; Subunits composition

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CEREBELLUM; CHANNEL GATING; COORDINATION; GLYCOSYLATION; HUMAN; LEARNING; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NITROSYLATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; SYNAPTIC TRANSMISSION;

ALTERNATIVE SPLICING; ANIMALS; CEREBELLUM; CEREBRAL CORTEX; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 25144476893     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220510007996     Document Type: Article

References (47)

1. Audinat E, Lambolez B, Rossier J, Crepel F. Activity-dependent regulation of N-methyl-D-aspartate receptor sub-unit expression in rat cerebellar granule cells. Eur J Neurosci. 1994;6:1792-800.
2. Farrant M, Feldmeyer D, Takahashi T, Cull-Candy SG. NMDA-receptor channel diversity in the developing cerebellum. Nature. 1994;368:335-9.
3. Cathala L, Misra C, Cull-Candy S. Developmental profile of the changing properties of NMDA receptors at cerebellar mossy fiber-granule cell synapses. J Neurosci. 2000;20:5899-905.
4. Takahashi T, Feldmeyer D, Suzuki N, Onodera K, Cull-Candy SG, Sakimura K, Mishina M. Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. J Neurosci. 1996;16:4376-82.
5. Schlett K, Pieri I, Metzger F, Marchetti L, Steigerwald F, Dere E, Kirilly D, Tarnok K, Barabas B, Kis VA, Gerspach J, Huston J, Pfizenmaier K, Kohr G, Eisel UL. Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits. Mol Cell Neurosci. 2004;27:215-26.
6. Losi G, Prybylowski K, Fu Z, Luo J, Wenthold RJ, Vicini S. PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. J Physiol. 2003;548(Pt. 1):21-9.
7. Matsuda K, Kamiya Y, Matsuda S, Yuzaki M. Cloning and characterization of a novel NMDA receptor subunit NR3B: A dominant subunit that reduces calcium permeability. Brain Res Mol Brain Res. 2002;100:43-52.
8. Prybylowski K, Rumbaugh G, Wolfe BB, Vicini S. Increased exon 5 expression alters extrasynaptic NMDA receptors in cerebellar neurons. J Neurochem. 2000;75(3):1140-6.
9. Rumbaugh G, Prybylowski K, Wang JF, Vicini S. Exon 5 and spermine regulate deactivation of NMDA receptor subtypes. J Neurophysiol. 2000;83(3):1300-6.
10. Vallano ML, Beaman-Hall CM, Benmansour S. Ca2+ and pH modulate alternative splicing of exon 5 in NMDA receptor subunit 1. Neuroreport. 1999;10:3659-64.
11. Prybylowski KL, Wolfe BB. Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum. Brain Res Dev Brain Res. 2000;123(2):143-50.
12. Widdowson PS, Trainor A, Lock EA. NMDA receptors in rat cerebellum and forebrain: Subtle differences in pharmacology and modulation. J Neurochem. 1995;64:651-61.
13. Stone TW. Subtypes of NMDA receptors. Gen Pharmacol. 1993;24:825-32.
14. Monaghan DT, Beaton JA. Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur J Pharmacol. 1991;194:123-5.
15. Yoneda Y, Ogita K. Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques. J Pharmacol Exp Ther. 1991;259:86-96.
16. Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem. 1997;272:5157-66.
17. Sánchez-Pérez AM, Felipo V. Serines 890 and 896 of NMDA receptor subunit NRl are differentially phosphorylated by protein kinase C isoforms. Neurochemistry International. 2005.
18. Llansola M, Sanchez-Perez AM, Montoliu C, Felipo V. Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture. J Neurochem. 2004;91:591-9.
19. Grant ER, Bacskai BJ, Anegawa NJ, Pleasure DE, Lynch DR. Opposing contributions of NR1 and NR2 to protein kinase C modulation of NMDA receptors. J Neurochem. 1998;71:1471-81.
20. Pizzi M, Boroni F, Bianchetti KM, Memo M, Spano P. Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expression. Eur J Neurosci. 1999;11:2489-96.
21. Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB. Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem. 1996;271:31670-8.
22. Corsi L, Li JH, Krueger KE, Wang YH, Wolfe BB, Vicini S. Up-regulation of NR2B subunit of NMDA receptors in cerebellar granule neurons by Ca2+/calmodulin kinase inhibitor KN93. J Neurochem. 1998;70:1898-906.
23. Gardoni F, Bellone C, Cattabeni F, Di Luca M. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem. 2001;276(10):7609-13.
24. Krupp JJ, Vissel B, Thomas CG, Heinemann SF, Westbrook GL. Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors. Neuropharmacology. 2002;42(5):593-602.
25. Jin DH, Jung YW, Ko BH, Moon IS. Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Mol Cells. 1997;7:749-54.
26. Dunah AW, Standaert DG. Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane. J Neurosci. 2001;21(15):5546-58.
27. Rostas JA, Brent VA, Voss K, Errington ML, Bliss TV, Gurd JW. Enhanced ryrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation. Proc Natl Acad Sci USA. 1996;93:10452-6.
28. Brose N, Gasic GP, Vetter DE, Sullivan JM, Heinemann SF. Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J Biol Chem. 1993;268:22663-71.
29. Dunah AW, Yasuda RP, Wang YH, Luo J, Davila-Garcia M, Gbadegesin M, Vicini S, Wolfe BB. Regional and ontogenic expression of the NMDA receptor subunit NR2D protein in rat brain using a subunit-specific antibody. J Neurochem. 1996;67:2335-45.
30. Chazot PL, Cik M, Stephenson FA. An investigation into the role of N-glycosylation in the functional expression of a recombinant heteromeric NMDA receptor. Mol Membr Biol. 1995;12:331-7.
31. Choi YB, Tenneti L, Le DA, Ortiz J, Bai G, Chen HS, Lipton SA. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci. 2000;3:15-21.
32. Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad. Sci USA. 1989;86:9030-3.
33. Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem. 1999;274:27467-73.
34. Kornau HC, Schenker LT, Kennedy MB, Seeburg PH. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995;269:1737-40.
35. Ziff EB. Enlightening the postsynaptic density. Neuron. 1997;19:1163-74.
36. Wyszynski M, Lin J, Rao A, Nigh E, Beggs AH, Craig AM, Sheng M. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature. 1997;385:439-42.
37. Rao A, Craig AM. Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons. Neuron. 1997;19:801-12.
38. Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of post-synaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998;18:8805-13.
39. Bassand P, Bernard A, Rafiki A, Gayet D, Khrestchatisky M. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Eur J Neurosci. 1999;11:2031-43.
40. Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci USA. 2002;99(21):13902-7.
41. Lee S, Maler L, Dunn RJ. Differential expression of the PSD-95 gene family in electrosensory neurons. J Comp Neurol. 2000;426(3):429-40.
42. Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci. 1998;18:2017-27.
43. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science. 1999;285:93-6.
44. Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci. 1998;11:161-72.
45. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells. 1997;2:415-24.
46. Abe M, Fukaya M, Yagi T, Mishina M, Watanabe M, Sakimura K. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J Neurosci. 2004;24(33): 7292-304.
47. Prybylowski K, Fu Z, Losi G, Hawkins LM, Luo J, Chang K, Wenthold RJ, Vicini S. Relationship between availability of NMDA receptor subunits and their expression at the synapse. J Neurosci. 2002;22(20):8902-10.