Effect of NOS inhibition on retinal arterial and capillary circulation in early arterial hypertension

Retina

Volumn 26, Issue 4, 2006, Pages 437-444

  Michelson, Georg ^a,b   Wärntges, Simone ^a   Harazny, Joana ^a   Oehmer, Sebastian ^a   Delles, Christian ^a   Schmieder, Roland E ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Endothelial function; Hypertension; Nitric oxide; Retinal circulation

Indexed keywords

CANDESARTAN HEXETIL; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; BENZIMIDAZOLE DERIVATIVE; BIPHENYL DERIVATIVE; ENZYME INHIBITOR; TETRAZOLE DERIVATIVE;

ADULT; ARTERY CONSTRICTION; ARTICLE; BIOSYNTHESIS; BLOOD FLOW VELOCITY; BLOOD VESSEL TONE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE COURSE; DOUBLE BLIND PROCEDURE; ENZYME INHIBITION; HEART OUTPUT; HUMAN; HYPERTENSION; MEAN ARTERIAL PRESSURE; PATHOGENESIS; RETINA ARTERY; RETINA BLOOD FLOW; RETINA CAPILLARY; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; BLOOD PRESSURE; CAPILLARY; CIRCULATION; DRUG ANTAGONISM; INTRAVENOUS DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLOOD CIRCULATION; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAPILLARIES; CARDIAC OUTPUT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; HUMANS; HYPERTENSION; INFUSIONS, INTRAVENOUS; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; RECEPTORS, ANGIOTENSIN; RETINAL ARTERY; TETRAZOLES;

EID: 33745073561     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006982-200604000-00010     Document Type: Article

References (58)

1. Haefliger IO, Flammer J, Beny JL, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog Retin Eye Res 2001;20:209-225. Review.
2. Schmetterer L, Polak K. Role of nitric oxide in the control of ocular blood flow. Prog Retin Eye Res 2001;20:823-847. Review.
3. Toda N, Zhang JX, Ayajiki K, Okamura T. Mechanisms underlying endothelium-independent relaxation by acetylcholine in canine retinal and cerebral arteries. J Pharmacol Exp Ther 1995;274:1507-1512.
4. Chakravarthy U, Stitt AW, McNally J, Bailie JR, Hoey EM, Duprex P. Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes. Curr Eye Res 1995;14:285-294.
5. Kelley C, D'Amore P, Hechtman HB, Shepro D. Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall. J Cell Biol 1987;104:483-490.
6. Haefliger IO, Meyer P, Flammer J, Luscher TF. The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology? Surv Ophthalmol 1994;39:123-132. Review.
7. Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res 2000;32:249-256. Review.
8. Hayreh SS. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 2001;20:595-624. Review.
9. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989;2:997-1000.
10. Donati G, Pournaras CJ, Munoz JL, Poitry S, Poitry-Yamate CL, Tsacopoulos M. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci 1995;36:2228-2237.
11. Buerk DG, Riva CE, Cranstoun SD. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc Res 1996;52:13-26.
12. Calver A, Collier J, Moncada S, Vallance P. Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens 1992;10:1025-1031.
13. Chan NN, Vallance P, Colhoun HM. Nitric oxide and vascular responses in Type I diabetes. Diabetologia 2000;43:137-147. Review.
14. Lüscher TF, Vanhoutte PM. The Endothelium: Modulator of Cardiovascular Function. Boca Raton, FL: CRC Press, 1990:1-228.
15. Tesfamariam B, Halpern W. Endothelium-dependent and endothelium- independent vasodilation in resistance arteries from hypertensive rats. Hypertension 1988;11:440-444.
16. Lind L, Millgard J, Sarabi M, Kahan T, Malmqvist K, Hagg A. Endothelium-dependent vasodilatation in treated and untreated hypertensive subjects. Blood Press 1999;8:158-164.
17. Diederich D, Yang ZH, Buhler FR, Luscher TF. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am J Physiol 1990;258(2 Pt 2):H445-H451.
18. Barton M, Vos I, Shaw S, et al. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis. J Am Soc Nephrol 2000;11:835-845.
19. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology 1982;89:1132-1145.
20. White RP, Deane C, Vallance P, Markus HS. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. Stroke 1998;29:467-472.
21. Noll G, Tschudi M, Nava E, Luscher TF. Endothelium and high blood pressure. Int J Microcirc Clin Exp 1997;17:273-279. Review.
22. Riva-Rocci S. Un nuovo sfigmomanometro (A new sphygmomanometer) [Italian]. Gazzetta Medica di Torino 1896;50:981-996.
23. Delles C, Michelson G, Harazny J, Oehmer S, Hilgers KF, Schmieder RE. Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke 2004;35:1289-1293.
24. Schmidt TF, Wittenhaus J, Steinmetz TF, Piccolo P, Lupsen H. Twenty-four-hour ambulatory noninvasive continuous finger blood pressure measurement with PORTAPRES: a new tool in cardiovascular research. J Cardiovasc Pharmacol 1992;19:S117-S145.
25. Wesseling KH, Jansen JR, Settels JJ, Schreuder JJ. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol 1993;74:2566-2573.
26. Jellema WT, Wesseling KH, Groeneveld AB, Stoutenbeek CP, Thijs LG, van Lieshout JJ. Continuous cardiac output in septic shock by simulating a model of the aortic input impedance: a comparison with bolus injection thermodilution. Anesthesiology 1999;90:1317-1328.
27. Harms MP, Wesseling KH, Pott F, et al. Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin Sci (Lond) 1999;97:291-301.
28. Michelson G, Patzelt A, Harazny J. Flickering light increases retinal blood flow. Retina 2002;22:336-343.
29. Michelson G, Welzenbach J, Pal I, Harazny J. Automatic full field analysis of perfusion images gained by scanning laser Doppler flowmetry. Br J Ophthalmol 1998;82:1294-1300.
30. Michelson G, Groh M, Langhans M, Schmauss B. 2-dimensional mapping and retinal and papillary microcirculation using scanning laser Doppler flowmetry. Klin Monatsbl Augenheilkd 1995;207:180-190.
31. Michelson G, Schmauss B. Two dimensional mapping of the perfusion of the retina and optic nerve head. Br J Ophthalmol 1995;79:1126-1132.
32. Michelson G, Zinser G, Schmauss B. Verfahren und Gerät zur Messung der Fliessgeschwindigkeit, insbesondere des Blutes 1.6.94. European patent no. 94108430.3.
33. Mayer BX, Mensik C, Krishnaswami S, et al. Pharmacokinetic- pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol 1999;47:539-544.
34. Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004;24:1023-1030.
35. Ueda S, Wada A, Umemura S. Methodological validity and feasibility of the nitric oxide clamp technique for nitric oxide research in human resistant vessels. Hypertens Res 2004;27:351-357.
36. Aisaka K, Gross SS, Griffith OW, Levi R. L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. Biochem Biophys Res Commun 1989;163:710-717.
37. Whittle BJ, Lopez-Belmonte J, Rees DD. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation. Br J Pharmacol 1989;98:646-652.
38. Bech JN, Nielsen CB, Pedersen EB. Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans. Am J Physiol 1996;270(5 Pt 2):F845-F851.
39. Wolzt M, Schmetterer L, Ferber W, et al. Effect of nitric oxide synthase inhibition on renal hemodynamics in humans: reversal by L-arginine. Am J Physiol 1997;272(2 Pt 2):F178-F182.
40. Jacobi J, Schneider MP, John S, Schmieder RE. Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects. J Hypertens 2002;20:525-530.
41. White RP, Hindley C, Bloomfield PM, et al. Effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study. J Cereb Blood Flow Metab 1999;19:673-678.
42. White RP, Deane C, Vallance P, Markus HS. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. Stroke 1998;29:467-472.
43. Hjorth Lassen L, Klingenberg Iversen H, Olesen J. A dose-response study of nitric oxide synthase inhibition in different vascular beds in man. Eur J Clin Pharmacol 2003;59:499-505.
44. Donati G, Pournaras CJ, Munoz JL, Poitry S, Poitry-Yamate CL, Tsacopoulos M. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci 1995;36:2228-2237.
45. Gidday JM, Zhu Y. Nitric oxide does not mediate autoregulation of retinal blood flow in newborn pig. Am J Physiol 1995;269(3 Pt 2):H1065-H1072.
46. Meyer P, Flammer J, Luscher TF. Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. Invest Ophthalmol Vis Sci 1993;34:3614-3621.
47. Sugiyama T, Oku H, Ikari S, Ikeda T. Effect of nitric oxide synthase inhibitor on optic nerve head circulation in conscious rabbits. Invest Ophthalmol Vis Sci 2000;41:1149-1152.
48. Kondo M, Wang L, Bill A. Vascular responses in retina and optic nerve to L-NAME, a nitric oxide blocker and flickering light in monkeys. Invest Ophthalmol Vis Sci 1995;36:S116.
49. Deussen A, Sonntag M, Vogel R. L-arginine-derived nitric oxide: a major determinant of uveal blood flow. Exp Eye Res 1993;57:129-134.
50. Luksch A, Polak K, Beier C, et al. Effects of systemic NO synthase inhibition on choroidal and optic nerve head blood flow in healthy subjects. Invest Ophthalmol Vis Sci 2000;41:3080-3084.
51. Dumskyj MJ, Eriksen JE, Dore CJ, Kohner EM. Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis. Microvasc Res 1996;51:378-392.
52. Mitchell JH, Schibye B, Payne FC 3rd, Saltin B. Response of arterial blood pressure to static exercise in relation to muscle mass, force development, and electromyographic activity. Circ Res 1981;48(6 Pt 2):I70-I75.
53. Schmetterer L, Krejcy K, Kastner J, et al. The effect of systemic nitric oxide-synthase inhibition on ocular fundus pulsations in man. Exp Eye Res 1997;64:305-312.
54. Calver A, Collier J, Leone A, Moncada S, Vallance P. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J Hum Hypertens 1993;7:193-194.
55. Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993;87:1468-1474.
56. Vallance P, Chan N. Endothelial function and nitric oxide: clinical relevance. Heart 2001;85:342-350. Review.
57. Delles C, Jacobi J, John S, Fleischmann I, Schmieder RE. Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. Kidney Int 2002;61:1462-1468.
58. Salvetti A, Mattei P, Sudano I. Renal protection and antihypertensive drugs: current status. Drugs 1999;57:665-693. Review.