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Volumn 47, Issue SUPPL. 2, 1998, Pages

Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs

Author keywords

Cyclooxygenase; In vitro in vivo assays; Nonsteroidal anti inflammatory drugs; Selectivity

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; ETODOLAC; FLOSULIDE; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; KETOPROFEN; L 754337; MECLOFENAMIC ACID; MELOXICAM; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NABUMETONE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTANOID; SULINDAC SULFIDE; TENIDAP; UNCLASSIFIED DRUG;

EID: 0031727033     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (97)

References (65)
  • 2
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:1692-6.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1692-1696
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3    Erikson, R.L.4    Simmons, D.L.5
  • 3
    • 0028044609 scopus 로고
    • Towards a better aspirin
    • Vane JR. Towards a better aspirin. Nature 1994;367:215-6.
    • (1994) Nature , vol.367 , pp. 215-216
    • Vane, J.R.1
  • 4
    • 0029983724 scopus 로고    scopus 로고
    • Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: Possible physiological and therapeutic implications
    • Pairet M, Engelhardt G. Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: possible physiological and therapeutic implications. Fundam Clin Pharmacol 1996;10:1-15.
    • (1996) Fundam Clin Pharmacol , vol.10 , pp. 1-15
    • Pairet, M.1    Engelhardt, G.2
  • 5
    • 4644274397 scopus 로고    scopus 로고
    • Overview of COX-2 in inflammation: From the biology to the clinic
    • Willoughby D, Tomlinson A, editors. Basel: Birkhäuser, in press
    • Pairet M, van Ryn J, Distel M. Overview of COX-2 in inflammation: From the biology to the clinic. In: Willoughby D, Tomlinson A, editors. Inducible Enzymes in the Inflammatory Response. Basel: Birkhäuser, 1998;in press.
    • (1998) Inducible Enzymes in the Inflammatory Response
    • Pairet, M.1    Van Ryn, J.2    Distel, M.3
  • 7
    • 0027146692 scopus 로고
    • Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993;90:11693-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11693-11697
    • Mitchell, J.A.1    Akarasereenont, P.2    Thiemermann, C.3    Flower, R.J.4    Vane, J.R.5
  • 8
    • 0028089109 scopus 로고
    • NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55-9.
    • (1994) Prostaglandins , vol.47 , pp. 55-59
    • Futaki, N.1    Takahashi, S.2    Yokoyama, M.3    Arai, I.4    Higuchi, S.5    Otomo, S.6
  • 10
    • 0030030129 scopus 로고    scopus 로고
    • Meloxicam: Influence on arachidonic acid metabolism: Part 1. in vitro findings
    • Engelhardt G, Bögel R, Schnitzler C, Utzmann R. Meloxicam: Influence on arachidonic acid metabolism: Part 1. In vitro findings. Biochem Pharmacol 1996;51:21-8.
    • (1996) Biochem Pharmacol , vol.51 , pp. 21-28
    • Engelhardt, G.1    Bögel, R.2    Schnitzler, C.3    Utzmann, R.4
  • 11
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
    • Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993;268:6610-4.
    • (1993) J Biol Chem , vol.268 , pp. 6610-6614
    • Meade, E.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 13
    • 0027992733 scopus 로고
    • Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
    • Barnett J, Chow J, Ives D, Chiou M, Mackenzie R, Osen E, et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1994;1209:130-9.
    • (1994) Biochim Biophys Acta , vol.1209 , pp. 130-139
    • Barnett, J.1    Chow, J.2    Ives, D.3    Chiou, M.4    Mackenzie, R.5    Osen, E.6
  • 15
    • 0027986841 scopus 로고
    • Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs
    • Laneuville O, Breuer DK, Dewitt DL, Hla T, Funk CD, Smith WD. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 1994;271:927-34.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 927-934
    • Laneuville, O.1    Breuer, D.K.2    Dewitt, D.L.3    Hla, T.4    Funk, C.D.5    Smith, W.D.6
  • 16
    • 0028123502 scopus 로고
    • Overexpression of human prostaglandin G/ H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
    • O'Neill GP, Mancini JA, Kargman S, Yergey J, Kwan MY, Falgueyret JP, et al. Overexpression of human prostaglandin G/ H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol Pharmacol 1994;45:245-54.
    • (1994) Mol Pharmacol , vol.45 , pp. 245-254
    • O'Neill, G.P.1    Mancini, J.A.2    Kargman, S.3    Yergey, J.4    Kwan, M.Y.5    Falgueyret, J.P.6
  • 17
    • 0029088821 scopus 로고
    • Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1
    • Glaser K, Sung ML, O'Neill K, Belfast M, Hartman D, Carlson R, et al. Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1. Eur J Pharmacol 1995;281:107-11.
    • (1995) Eur J Pharmacol , vol.281 , pp. 107-111
    • Glaser, K.1    Sung, M.L.2    O'Neill, K.3    Belfast, M.4    Hartman, D.5    Carlson, R.6
  • 18
    • 0028830109 scopus 로고
    • Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
    • Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, Isakson PC, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J 1995;305:479-84.
    • (1995) Biochem J , vol.305 , pp. 479-484
    • Gierse, J.K.1    Hauser, S.D.2    Creely, D.P.3    Koboldt, C.4    Rangwala, S.H.5    Isakson, P.C.6
  • 20
    • 0030582843 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays
    • Cromlish WA, Kennedy BP. Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays. Biochem Pharmacol 1996;52:1777-85.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1777-1785
    • Cromlish, W.A.1    Kennedy, B.P.2
  • 21
    • 0030580035 scopus 로고    scopus 로고
    • Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
    • Kargman S, Wong E, Greig GM, Falgueyret JP, Cromlish W, Ethier D, et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem Pharmacol 1996;52:1113-25.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1113-1125
    • Kargman, S.1    Wong, E.2    Greig, G.M.3    Falgueyret, J.P.4    Cromlish, W.5    Ethier, D.6
  • 22
    • 8244255009 scopus 로고    scopus 로고
    • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
    • Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol 1997;121:105-17.
    • (1997) Br J Pharmacol , vol.121 , pp. 105-117
    • Riendeau, D.1    Percival, M.D.2    Boyce, S.3    Brideau, C.4    Charleson, S.5    Cromlish, W.6
  • 23
    • 0027940487 scopus 로고
    • Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases
    • Patrignani P, Panara MR, Greco A, Fusco O, Natoli C, Iacobelli S, et al. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J Pharmacol Exp Ther 1994;271:1705-10.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1705-1710
    • Patrignani, P.1    Panara, M.R.2    Greco, A.3    Fusco, O.4    Natoli, C.5    Iacobelli, S.6
  • 24
  • 26
    • 0030022032 scopus 로고    scopus 로고
    • A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
    • Brideau C, Kargman S, Liu S, Dallob AL, Ehrich EW, Rodger IW, et al. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors. Inflamm Res 1996;45:68-74.
    • (1996) Inflamm Res , vol.45 , pp. 68-74
    • Brideau, C.1    Kargman, S.2    Liu, S.3    Dallob, A.L.4    Ehrich, E.W.5    Rodger, I.W.6
  • 29
  • 30
    • 0345351137 scopus 로고    scopus 로고
    • NSAIDs effects on COX-1 and COX-2 activity in human articular chondrocytes
    • Blanco F, Guitian R, Moreno J, Hernandez A, Freire M, Atanes A, et al. NSAIDs effects on COX-1 and COX-2 activity in human articular chondrocytes [abstract]. Arthritis Rheum 1997;40 (Suppl 9):347.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 347
    • Blanco, F.1    Guitian, R.2    Moreno, J.3    Hernandez, A.4    Freire, M.5    Atanes, A.6
  • 31
    • 0002131850 scopus 로고    scopus 로고
    • Differential inhibition of COX-1 and COX-2 by nonsteroidal anti-inflammatory drugs in cultured synovial cells
    • Vergne P, Bertin P, Liagre B, Bonnet C, Pairet M, Rigaud M, et al. Differential inhibition of COX-1 and COX-2 by nonsteroidal anti-inflammatory drugs in cultured synovial cells [abstract]. Arthritis Rheum 1997;40 (Suppl 9):375.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 375
    • Vergne, P.1    Bertin, P.2    Liagre, B.3    Bonnet, C.4    Pairet, M.5    Rigaud, M.6
  • 32
    • 26844555502 scopus 로고    scopus 로고
    • Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human synovial cells and platelets
    • Singapore, June 8-13, abstract 156
    • Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human synovial cells and platelets. In: Proceedings of the 19th ILAR Congress of Rheumatology, Singapore, June 8-13, 1997, abstract 156.
    • (1997) Proceedings of the 19th ILAR Congress of Rheumatology
    • Kawai, S.1    Nishida, S.2    Kato, M.3    Furumaya, Y.4    Okamoto, R.5    Koshino, T.6
  • 33
    • 0029145880 scopus 로고
    • NSAIDs, Cox-2 inhibitors, and the gut
    • Hayllar J, Bjarnason I. NSAIDs, Cox-2 inhibitors, and the gut. Lancet 1995;346:521-2.
    • (1995) Lancet , vol.346 , pp. 521-522
    • Hayllar, J.1    Bjarnason, I.2
  • 34
    • 0029758675 scopus 로고    scopus 로고
    • Nimesulide: A selective cyclooxygenase 2 inhibitor antiinflammatory drug
    • Rabasseda X. Nimesulide: A selective cyclooxygenase 2 inhibitor antiinflammatory drug. Drugs Today 1996;32 (Suppl D):1-23.
    • (1996) Drugs Today , vol.32 , Issue.SUPPL. D , pp. 1-23
    • Rabasseda, X.1
  • 36
    • 0029611205 scopus 로고
    • Cyclooxygenase selectivity and NSAIDs: Cyclooxygenase-2 selectivity of etodolac (Lodine)
    • Glaser K. Cyclooxygenase selectivity and NSAIDs: Cyclooxygenase-2 selectivity of etodolac (Lodine). Inflammopharmacology 1995;3:335-45.
    • (1995) Inflammopharmacology , vol.3 , pp. 335-345
    • Glaser, K.1
  • 39
    • 0028122558 scopus 로고
    • Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
    • Davis R, Bodgen RN. Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1994;48:431-54.
    • (1994) Drugs , vol.48 , pp. 431-454
    • Davis, R.1    Bodgen, R.N.2
  • 40
    • 0002277454 scopus 로고
    • Analgesic-antipyretic and antiinflammatory agents
    • Goodman Gilman A, Rau TW, Nies As, Taylor P, editors. New York Pergamon Press
    • Insel PA. Analgesic-antipyretic and antiinflammatory agents. In: Goodman Gilman A, Rau TW, Nies As, Taylor P, editors. The Pharmacological Bases of Therapeutics. 8th ed. New York Pergamon Press 1985:638-81.
    • (1985) The Pharmacological Bases of Therapeutics. 8th Ed. , pp. 638-681
    • Insel, P.A.1
  • 42
    • 0028823462 scopus 로고
    • Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations
    • Day RO, Francis H, Vial J, Geisslinger G, Williams KM. Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations. J Rheumatol 1995;22:2295-303.
    • (1995) J Rheumatol , vol.22 , pp. 2295-2303
    • Day, R.O.1    Francis, H.2    Vial, J.3    Geisslinger, G.4    Williams, K.M.5
  • 44
    • 0025292995 scopus 로고
    • Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis
    • Taha AS, McLaughlin S, Holland PJ, Kelly RW, Sturrock RD, Russell RI. Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis. Ann Rheum Dis 1990;49:354-8.
    • (1990) Ann Rheum Dis , vol.49 , pp. 354-358
    • Taha, A.S.1    McLaughlin, S.2    Holland, P.J.3    Kelly, R.W.4    Sturrock, R.D.5    Russell, R.I.6
  • 45
    • 0027309070 scopus 로고
    • Effect of Heticobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs
    • Hudson N, Balsitis M, Filipowicz F, Hawkey C. Effect of Heticobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993;34:748-51.
    • (1993) Gut , vol.34 , pp. 748-751
    • Hudson, N.1    Balsitis, M.2    Filipowicz, F.3    Hawkey, C.4
  • 46
    • 0028156830 scopus 로고
    • Sodium naproxen: Concentration and effect on inflammatory response mediators in human rheumatoid synovial fluid
    • Bertin P, Lapicque F, Payan E, Rigaud M, Bailleul F, Jaeger S, et al. Sodium naproxen: Concentration and effect on inflammatory response mediators in human rheumatoid synovial fluid. Clin Pharmacol 1994;46:3-7.
    • (1994) Clin Pharmacol , vol.46 , pp. 3-7
    • Bertin, P.1    Lapicque, F.2    Payan, E.3    Rigaud, M.4    Bailleul, F.5    Jaeger, S.6
  • 47
    • 0018096778 scopus 로고
    • Relationship between plasma concentrations of indomethacin and its effect on prostaglandin synthesis and platelet aggregation in man
    • Rane A, Oelz O, Frölich JC, Seyberth HW, Sweetman BJ, Watson J, et al. Relationship between plasma concentrations of indomethacin and its effect on prostaglandin synthesis and platelet aggregation in man. Clin Pharmacol Ther 1978;23:658-68.
    • (1978) Clin Pharmacol Ther , vol.23 , pp. 658-668
    • Rane, A.1    Oelz, O.2    Frölich, J.C.3    Seyberth, H.W.4    Sweetman, B.J.5    Watson, J.6
  • 48
    • 0021206782 scopus 로고
    • Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans
    • Cronberg S, Wallmark E, Södeberg I. Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans. Scand J Haematol 1984;33:155-9.
    • (1984) Scand J Haematol , vol.33 , pp. 155-159
    • Cronberg, S.1    Wallmark, E.2    Södeberg, I.3
  • 49
    • 0021954202 scopus 로고
    • Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin
    • Vinge E. Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin. Eur J Clin Pharmacol 1985; 28:163-9.
    • (1985) Eur J Clin Pharmacol , vol.28 , pp. 163-169
    • Vinge, E.1
  • 50
    • 0023257901 scopus 로고
    • Relationships between thromboxane production, platelet aggregability, and serum concentrations of ibuprofen and flurbiprofen
    • Cox SR, Vanderlugt JT, Gumbleton TJ, Smith RB. Relationships between thromboxane production, platelet aggregability, and serum concentrations of ibuprofen and flurbiprofen. Clin Pharmacol Ther 1987;41:510-21.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 510-521
    • Cox, S.R.1    Vanderlugt, J.T.2    Gumbleton, T.J.3    Smith, R.B.4
  • 51
    • 0028922825 scopus 로고
    • Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis
    • Schaf er AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995; 35:209-19.
    • (1995) J Clin Pharmacol , vol.35 , pp. 209-219
    • Schafer, A.I.1
  • 53
    • 0027448824 scopus 로고
    • Renal effects of nimesulide in furosemide-treated subjects
    • Steinhäuslin F, Munajo A, Buclin T, Macciochi A, Biollaz J. Renal effects of nimesulide in furosemide-treated subjects. Drugs 1993;46 (Suppl 1):257-62.
    • (1993) Drugs , vol.46 , Issue.1 SUPPL. , pp. 257-262
    • Steinhäuslin, F.1    Munajo, A.2    Buclin, T.3    Macciochi, A.4    Biollaz, J.5
  • 54
    • 0031063550 scopus 로고    scopus 로고
    • Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers
    • Stichtenoth DO, Wagner B, Frölich JC. Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers. J Invest Med 1997;45:44-9.
    • (1997) J Invest Med , vol.45 , pp. 44-49
    • Stichtenoth, D.O.1    Wagner, B.2    Frölich, J.C.3
  • 55
    • 0025607874 scopus 로고
    • Endoscopic evaluation of etodolac and naproxen and their relative effects on gastric and duodenal prostaglandins
    • Russell RI. Endoscopic evaluation of etodolac and naproxen and their relative effects on gastric and duodenal prostaglandins. Rheum Int 1990;10:17-21.
    • (1990) Rheum Int , vol.10 , pp. 17-21
    • Russell, R.I.1
  • 56
    • 0001793772 scopus 로고    scopus 로고
    • A study of the platelet effects of SC-58635, a novel COX-2 selective inhibitor
    • Mengle-Gaw L, Hubbard R, Karim A, Yu S, Talwalker S, Isakson P. A study of the platelet effects of SC-58635, a novel COX-2 selective inhibitor [abstract]. Arthritis Rheum 1997; 40 (Suppl 9):374.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 374
    • Mengle-Gaw, L.1    Hubbard, R.2    Karim, A.3    Yu, S.4    Talwalker, S.5    Isakson, P.6
  • 57
    • 0002742704 scopus 로고    scopus 로고
    • Pilot efficacy of SC-58635, a COX-2 selective inhibitor, in rheumatoid arthritis
    • Hubbard R, Koepp R, Yu S, Talwalker S, Geis S. Pilot efficacy of SC-58635, a COX-2 selective inhibitor, in rheumatoid arthritis [abstract]. Arthritis Rheum 1997;40 (Suppl 9):125.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 125
    • Hubbard, R.1    Koepp, R.2    Yu, S.3    Talwalker, S.4    Geis, S.5
  • 58
    • 0000204747 scopus 로고    scopus 로고
    • Effect of celecoxib, a novel COX-2 inhibitor, on health-related quality of life in patients with osteoarthritis of the knee
    • Zhao S, Hatoum H, Hubbard R, Koepp R, Dedhiya S, Geis S, et al. Effect of celecoxib, a novel COX-2 inhibitor, on health-related quality of life in patients with osteoarthritis of the knee [abstract]. Arthritis Rheum 1997;40 (Suppl 9):348.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 348
    • Zhao, S.1    Hatoum, H.2    Hubbard, R.3    Koepp, R.4    Dedhiya, S.5    Geis, S.6
  • 60
    • 0001867832 scopus 로고    scopus 로고
    • Efficacy of MK-966, a highly selective inhibitor of COX-2 in the treatment of postoperative dental pain
    • Ehrich E, Mehlisch D, Perkins S, Brown P, Wittreich J, Lipschutz K, et al. Efficacy of MK-966, a highly selective inhibitor of COX-2 in the treatment of postoperative dental pain [abstract]. Arthritis Rheum 1996;39 (Suppl 9):329.
    • (1996) Arthritis Rheum , vol.39 , Issue.9 SUPPL. , pp. 329
    • Ehrich, E.1    Mehlisch, D.2    Perkins, S.3    Brown, P.4    Wittreich, J.5    Lipschutz, K.6
  • 61
    • 0000750985 scopus 로고    scopus 로고
    • MK-966, a highly selective COX-2 inhibitor, was effective in the treatment of osteoarthritis (OA) of the knee and hip in a 6 week placebo controlled study
    • Ehrich E, Schnitzler T, Kivitz A, Weaver A, Wolfe F, Morrison B, et al. MK-966, a highly selective COX-2 inhibitor, was effective in the treatment of osteoarthritis (OA) of the knee and hip in a 6 week placebo controlled study [abstract]. Arthritis Rheum 1997;40 (Suppl 9):330.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 SUPPL. , pp. 330
    • Ehrich, E.1    Schnitzler, T.2    Kivitz, A.3    Weaver, A.4    Wolfe, F.5    Morrison, B.6
  • 62
    • 0002180220 scopus 로고    scopus 로고
    • Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs
    • Bazan N, Botting J, Vane J, editors. Dordrecht: Kluwer Academic; London: William Harvey Press
    • Pairet M, Churchill L, Engelhardt G. Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs. In: Bazan N, Botting J, Vane J, editors. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules. Dordrecht: Kluwer Academic; London: William Harvey Press 1996:23-38.
    • (1996) New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules , pp. 23-38
    • Pairet, M.1    Churchill, L.2    Engelhardt, G.3
  • 63
    • 0003111606 scopus 로고    scopus 로고
    • The history of anti-inflammatory drugs and their mechanism of action
    • Bazan N, Botting J, Vane J, editors. Dordrecht: Kluwer Academic; London: William Harvey Press
    • Vane JR, Botting RM. The history of anti-inflammatory drugs and their mechanism of action. In: Bazan N, Botting J, Vane J, editors. New Targels in Inflammation: Inhibitors of COX-2 or Adhesion Molecules. Dordrecht: Kluwer Academic; London: William Harvey Press 1996:1-12.
    • (1996) New Targels in Inflammation: Inhibitors of COX-2 or Adhesion Molecules , pp. 1-12
    • Vane, J.R.1    Botting, R.M.2
  • 64
    • 0031034254 scopus 로고    scopus 로고
    • A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes
    • Frölich J. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci 1997;18:30-4.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 30-34
    • Frölich, J.1
  • 65
    • 0030911724 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibitors: Pharmacology, clinical effects and therapeutic potential
    • van Ryn J, Pairel M. Selective cyclooxygenase-2 inhibitors: pharmacology, clinical effects and therapeutic potential. Exp Opin Invest Drugs 1997;6:609-14.
    • (1997) Exp Opin Invest Drugs , vol.6 , pp. 609-614
    • Van Ryn, J.1    Pairel, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.