Use of fed-batch cultivation for achieving high cell densities for the pilot-scale production of a recombinant protein (phenylalanine dehydrogenase) in Escherichia coli

Biotechnology Progress

Volumn 22, Issue 3, 2006, Pages 889-897

  Faulkner, Eilis ^a   Barrett, Mark ^a   Okor, Sola ^a   Kieran, Patricia ^a   Casey, Eoin ^a   Paradisi, Francesca ^a   Engel, Paul ^a   Glennon, Brian ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYME INHIBITION; ENZYME KINETICS; GROWTH KINETICS; METABOLISM; PROTEINS;

BATCH CULTIVATION; CELL CONCENTRATIONS; PILOT-SCALE PRODUCTION; STARVATION PERIODS;

ESCHERICHIA COLI;

OXIDOREDUCTASE; PHENYLALANINE OXIDASE; RECOMBINANT PROTEIN;

ARTICLE; BIOLOGICAL MODEL; BIOMASS; BIOSYNTHESIS; CULTURE MEDIUM; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; FERMENTATION; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; TIME;

AMINO ACID OXIDOREDUCTASES; BACTERIOLOGICAL TECHNIQUES; BIOMASS; CULTURE MEDIA, CONDITIONED; ESCHERICHIA COLI; FERMENTATION; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS; TIME FACTORS;

ESCHERICHIA COLI;

EID: 33745029262     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp050327+     Document Type: Article

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