Self-reactive CD4 + T cells and B cells in the blood in health and autoimmune disease: Increased frequency of thyroglobulin-reactive cells in Graves' disease

Journal of Clinical Immunology

Volumn 26, Issue 2, 2006, Pages 126-137

  Nielsen, Claus H ^a,b   Moeller, Ane Christine ^c   Hegedüs, Laszlo ^d   Bendtzen, Klaus ^a   Leslie, R Graham Q ^c  

^a Rigshospitalet   (Denmark)

^b Mental Health Services CPH   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Autoantibodies; Autoimmunity; B lymphocytes; Complement; T lymphocytes

Indexed keywords

TETANUS TOXOID; THYROGLOBULIN;

ANTIBODY DEPENDENT ENHANCEMENT; ANTIGEN DETECTION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPLEMENT SYSTEM; CONTROLLED STUDY; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; THYROGLOBULIN BLOOD LEVEL;

AUTOANTIBODIES; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; COMPLEMENT SYSTEM PROTEINS; GRAVES DISEASE; HASHIMOTO DISEASE; HUMANS; LYMPHOCYTE ACTIVATION; THYROGLOBULIN;

EID: 33744995604     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-006-9000-z     Document Type: Article

References (35)

1. Miller JF, Heath WR: Post-thymic T-cell tolerance or indifference: That is the question. Res Immunol 143:313-315, 1992
2. Ohashi PS, Oehen S, Buerki K, Pircher H, Ohashi CT Odermatt B, Malissen B, Zinkernagel RM, Hengartner H: Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305-317, 1991
3. Vladutiu AO, Rose NR: Transfer of experimental autoimmune thyroiditis of the mouse by serum. J Immunol 106:1139-1142, 1971
4. Totterman TH: Distribution of T-, B-, and thyroglobulin-binding lymphocytes infiltrating the gland in Graves' disease, Hashimoto's thyroiditis, and de Quervain's thyroiditis. Clin Immunol Immunopathol 10:270-277, 1978
5. Mellors RC, Brzosko WJ, Sonkin LS: Immunopathology of chronic non-specific thyroiditis (autoimmune thyroiditis). Am J Pathol 41:425-437, 1962
6. Tomer Y: Anti-thyroglobulin autoantibodies in autoimmune thyroid diseases: Cross-reactive or pathogenic? Clin Immunol Immunopathol 82:3-11, 1997
7. Rees Smith B, McLachlan SM, Furmaniak J: Autoantibodies to the thyrotropin receptor. Endocr Rev 9:106-121, 1988
8. Volpé R: B-lymphocytes in autoimmune thyroid diseases (AITD). Rev Endocr Metab Disord 1:79-86, 2000
9. + T cells in healthy individuals. Eur J Immunol 31:2660-2668, 2001
10. + T cell proliferation in response to self antigens. Eur J Immunol 34:263-272, 2004
11. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT: C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity. Science 271:348-350, 1996
12. Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC: Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med 183:1857-1864, 1996
13. Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM: B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in non-obese diabetic mice. J Immunol 161:3912-3918, 1998
14. Falcone M, Lee J, Patstone G, Yeung B, Sarvetnick N: B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in non-obese diabetic mice. J Immunol 161:1163-1168, 1998
15. Chan OT, Madaio MP, Shlomchik MJ: B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. J Immunol 163:3592-3596, 1999
16. Edwards JCW, Cambridge G: Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology 40:205-211, 2001
17. Romball CG, Weigle WO: Transfer of experimental autoimmune thyroiditis with T cell clones. J Immunol 138:1092-1098, 1987
18. Maron R, Zerubavel R, Friedman A, Cohen IR: T lymphocytes specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J Immunol 131:2316-2322, 1983
19. Okayasu I: Transfer of experimental autoimmune thyroiditis to normal syngeneic mice by injection of mouse thyroglobulin-sensitized T lymphocytes after activation with concanavalin A. Clin Immunol Immunopathol 36:101-119, 1985
20. Inoue K, Niesen K, Milgrom F, Albini B: Transfer of experimental autoimmune thyroiditis by in situ perfusion of thyroids with immune sera. J Immunol 66:11-17, 1993
21. Givan AL, Fisher JL, Waugh M, Ernstoff MS, Wallace PK: A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens. A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens. J Immunol Methods 230:99-112, 1999
22. Tough DF, Sprent J: Anti-viral immunity: Spotting virus-specific T cells. Curr Biol 8:R498-R501, 1998
23. Mason D: A very high level of cross-reactivity is an essential feature of the T-cell receptor. Immunol Today 19:395-404, 1998
24. Martin A, Barbesino G, Davies TF: T-cell receptors and autoimmune thyroid disease - Signposts for T-cell-antigen driven diseases. Int Rev Immunol 18:111-140, 1999
25. Thornton BP, Vetvicka V, Ross GD: Function of C3 in a humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and primary antigen promotes antigen uptake and the expression of co-stimulatory molecules by all B cells, but only stimulates immunoglobulin synthesis by antigen-specific B cells. Clin Exp Immunol 104:531-537, 1996
26. Chen ZJ, Wheeler CJ, Shi W, Wu AJ, Yarboro CH, Gallagher M, Notkins AL: Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire. Eur J Immunol 28:989-994, 1998
27. Avrameas S: Natural autoantibodies. From 'horror autotoxicus' to 'gnothi seauton'. Immunol Today 12:154-159, 1981
28. Beall GN, Kruger SR: Anti-thyroglobulin (ATG) production by peripheral blood leukocytes in vitro. J Clin Endocrino Metab 48:712-714, 1979
29. Weetman AP, McGregor AM, Rennie DP, Hall R: Sites of autoantibody production in rats with thyroiditis. Immunology 46:465-472, 1982
30. McLachlan SM, Pegg CA, Atherton MC, Middleton SL, Dickinson A, Clark F, Proctor SJ, Proud G, Rees Smith B: Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto thyroid glands. Clin Exp Immunol 65:319-328, 1986
31. Hutchings P, Rayner DC, Champion BR, Marshall-Clarke S, Macatonia S, Roitt I, Cooke A: High efficiency antigen presentation by thyroglobulin-primed murine splenic B cells. Eur J Immunol 17:393-398, 1987
32. Guo J, Wang Y, Rapoport B, McLachlan SM: Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II. Clin Exp Immunol 119:38-46, 2000
33. Bennedbaek FN, Grain J, Hegedus L: The transition of subacute thyroiditis to Graves' disease as evidenced by diagnostic imaging. Thyroid 6:457-459, 1996
34. Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM: T cell activation in rheumatoid synovium is B cell dependent. J Immunol 167:4710-4718, 2001
35. Chan OT, Madaio MP, Shlomchik MJ: B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. J Immunol 163:3592-3596, 1999