T-Cell Receptors and Autoimmune Thyroid Disease—Signposts for T-Cell-Antigen Driven Diseases

International Reviews of Immunology

Volumn 18, Issue 42006, 1999, Pages 111-140

  Martin, Andreas ^a   Barbesino, Giuseppe ^a   Davies, Terry F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune disease; Epitope; Graves' disease; Hashimoto'S thyroiditis; Hydrophobicity; Organoid; Restriction; Scid mice; T cell receptor; Thyroid; TSH receptor

Indexed keywords

ANIMAL MODEL; AUTOIMMUNE DISEASE; GRAVES DISEASE; HASHIMOTO DISEASE; T LYMPHOCYTE RECEPTOR; THYROID DISEASE; THYROTROPIN;

ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASES; HUMANS; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; THYROID DISEASES;

EID: 0032936982     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.3109/08830189909043021     Document Type: Article

References (75)

1. Katzin W., Fishleder A. J., Tubbs R. R. Investigation of the clonality of lymphocytes in Hashimoto's thyroiditis using immunoglobulin and T-cell receptor gene probes. Clin. Immunol. Immunopalhol. 1989; 51: 264 – 274
2. Davies T. F., Martin A., Conception E. S., Graves P., Cohen L., Nun Ben A. Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N. Engl. J. Med. 1991; 325: 238 – 244
3. Davies T. F., Martin A., Conception E. S., Graves P., Lahat N., Cohen W. L., Ben Nun A. Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J. Clin. Invest. 1992; 89: 157 – 162
4. Davies T. F., Conception E. S., Ben Nun A., Graves P. N., Tarjan G. T-cell receptor V gene use in autoimmune thyroid disease: direct assessment by thyroid aspiration. J. Clin. Endocrinol. Metab. 1993; 76: 660 – 666
5. Heufelder A. E., Wenzel B. E., Scriba P. C. Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital and pretibial tissue in Graves' disease. J. Clin. Endocrinol, and Metab. 1996; 81: 3733 – 3739
6. Bach J. F. T-cell receptor use in organ-specific human autoimmune diseases other than rheumatoid arthritis and multiple sclerosis. Summary and overview. Ann. N. Y. Acad. Sci. 1995; 756: 453 – 459
7. Martin A., Goldsmith N. K., Friedman E. W., Schwartz A. E., Davies T. F., Roman S. H. Intrathyroidal accumulation of T cell phenotypes in autoimmune thyroid disease. Autoimmunity 1990; 6: 269 – 281
8. Caso Pelaez E., McGregor A. M., Banga J. P., McIntosh R. S., Watson P. F., Pickerill A. P., Davies R., Weetman A. P. A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves' disease patients No restriction of intrathyroidal T cell receptor V alpha families in the thyroid of Graves' disease. Scand. J. Immunol. 1993; 91: 147 – 152
9. Caso Pelaez E., McGregor A. M., Banga J. P. A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves' disease patients. Scand. J. Immunol. 1995; 41: 141 – 147
10. McIntosh R. S., Tandon N., Pickerill A. P., Davies R., Barnett D., Weetman A. P. IL-2 receptor-positive intrathyroidal lymphocytes in Graves' disease. Analysis of V alpha transcript microheterogeneity. J. Immunol. 1993; 151: 3884 – 3893
11. McIntosh R. S., Watson P. F., Weetman A. P. Analysis of the T cell receptor V α repertoire in Hashimoto's thyroiditis: Evidence for the restricted accumulation of CD8+ T cells in the absence of CD4+ T cell restriction. J. Clin. Endocrinol. Metab. 1997; 82: 1140 – 1146
12. Nakashima M., Martin A., Davies T. F. Intrathyroidal T cell accumulation in Graves' disease: delineation of mechanisms based on in situ T cell receptor analysis. J. Clin. Endocrinol. Metab. 1996; 81: 3346 – 3351
13. Matsuoka N., Bernard N., Conception E. S., Graves P. N., Ben Nun A., Davies T. F. T-cell receptor V region beta-chain gene expression in the autoimmune thyroiditis of non-obese diabetic mice. J. Immunol. 1993; 151: 1691 – 1701
14. Bernard N. F., Ertug F., Margolese H. Studies of autoantibodies reactive with thyroid membrane antigens and insulin in non obese diabetic mice. High incidence of thyroiditis and anti-thyroid autoantibodies in NOD mice. Autoimmunity 1992; 41: 40 – 46
15. Penhale W. J., Young P. R. The influence of the normal microbial flora on the susceptibility of rats to experimental autoimmune thyroiditis. Clin. Exp. Immunol. 1988; 72: 288 – 292
16. Matsuoka N., Unger P., Ben Nun A., Graves P., Davies T. F. Thyroglobulin-induced murine thyroiditis assessed by intrathyroidal T cell receptor sequencing. J. Immunol. 1994; 152: 2562 – 2568
17. Kappler J. W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273 – 280
18. Sprent J., Gao E. K., Webb S. R. T cell reactivity to MHC molecules: immunity versus tolerance. Science 1990; 248: 1357 – 1363
19. Lynch D. H., Gress R. E., Needleman B. W., Rosenberg S. A., Hodes R. J. T cell responses to Mis determinants are restricted by cross-reactive MHC determinants. J. Immunol. 1985; 134: 2071 – 2078
20. Larsson Sciard E. L., Spetz Hagberg A. L., Casrouge A., Kourilsky P. Analysis of T cell receptor V beta gene usage in primary mixed lymphocyte reactions: evidence for directive usage by different antigen-presenting cells and Mis-like determinants on T cell blasts. Eur. J. Immunol. 1990; 20: 1223 – 1229
21. Steinberg A. D. Autologous mixed lymphocyte reactions-a commentary. Journal of Molecular and Cellular Immunology 1984; 1: 101
22. Kozak R. W., Moody C. E., Staiano Coico L., Weksler M. E. Lymphocyte transformation induced by autologous cells. XII. Quantitative and qualitative differences between human autologous and allogeneic reactive T lymphocytes. J. Immunol. 1982; 128: 1723 – 1727
23. Davies T. F., Piccinini L. A. Intrathyroidal MHC class II antigen expresssion and thyroid autoimmunity. Endocrinology and Metabolism Clinics of North America, J. R. Wall. W.B. Saunders, Toronto, 247 – 268
24. Mackenzie W. A., Schwartz A. E., Friedman E. W., Davies T. F. Intrathyroidal T cell clones from patients with autoimmune thyroid disease. J. Clin. Endocrinol. and Metab. 1987; 64: 818 – 824
25. Lahat N., Ben Nun A., Kinarty A., Davies T. F. Selection of human TcR V gene families in autologous mixed lymphocyte reactions: relevance to autoimmune immunopathology. Autoimmunity 1994; 18: 133 – 139
26. Bosma G. C., Custer R. P., Bosma M. J. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301: 527 – 530
27. Davies T. F., Kimura H., Fong P., Kendler D., Shultz L. D., Thung S., Martin A. The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion. Clin. Immunol. Immunopathol. 1991; 60: 319 – 330
28. Martin A., Kimura H., Thung S., Fong P., Shultz L. D., Davies T. F. Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis. Int. Arch. Allergy Immunol. 1992; 98: 317 – 323
29. Martin A., Valentine M., Unger P., Lichtenstein C., Schwartz A. E., Friedman E. W., Shultz L. D., Davies T. F. Preservation of functioning human thyroid “organoids” in the scid mouse: I. System characterization. J. Clin. Endocrinol. Metab. 1993; 77: 305 – 310
30. Matsuoka N., Martin A., Concepcion E. S., Unger P., Shultz L. D., Davies T. F. Preservation of functioning human thyroid organoids in the scid mouse: II. Biased use of intrathyroidal T cell receptor V genes. J. Clin. Endocrinol. Metab. 1993; 77: 311 – 315
31. Nakashima M., Martin A. Clonal T-cell response to hTSHR-peptide revealed by radio-labelled PCR. Thyroid, 5: S – 21, Abstr.)Supplement 1
32. Tandon N., Freeman M. A., Weetman A. P. T cell responses to synthetic TSH receptor peptides in Graves' disease. Clin. Exp. Immunol. 1992; 89: 468 – 473
33. Fan J. L., Desai R. K., Seetharamaiah G. S., Dallas J. S., Wagle N. M., Prabhakar B. S. Heterogeneity in cellular and antibody responses against thyrotropin receptor in patients with Graves' disease detected using synthetic peptides. J. Autoimmunity 1993; 6: 799 – 808
34. Sakata S., Tanaka S., Okuda K., Miura K., Manshouri T., Atassi M. Z. Autoimmune T-cell recognition sites of human thyrotropin receptor in Graves' disease. Mol. Cell Endocrinol. 1993; 92: 77 – 82
35. Okamoto Y., Yanagawa T., Fisfalen M. E., DeGroot L. J. Proliferative responses of peripheral blood mononuclear cells from patients with Graves' disease to synthetic peptides epitopes of human thyrotropin receptor. Thyroid 1994; 4: 37 – 42
36. Soliman M., Kaplan E., Abdel Latif A., Scherberg N., DeGroot L. J. Does thyroidectomy, radioactive iodine therapy, or antithyroid drug treatment alter reactivity of patients' T cells to epitopes of thyrotropin receptor in autoimmune thyroid diseases. J. Clin. Endocrinol. Metab. 1995; 80: 2312 – 2321
37. Nagy E. V., Morris J. C., Burch H. B., Bhatia S., Salata K., Burman K. D. Thyrotropin receptor T cell epitopes in autoimmune thyroid disease. Clin. Immunol. Immunopathol. 1995; 75: 117 – 124
38. Akamizu T., Ueda Y., Hua L., Okuda J., Mori T. Establishment and characterization of an antihuman thyrotropin (TSH) receptor-specific CD4+ T cell line from a patient with Graves' disease: evidence for multiple T cell epitopes on the TSH receptor including the transmembrane domain. Thyroid 1995; 5: 259 – 264
39. Kellermann S. A., McCormick D. J., Freeman S. L., Morris J. C., Conti B. M. Fine. TSH receptor sequences recognized by CD4+ T cells in Graves' disease patients and healthy controls. J. Autoimtn. 1996; 8: 695 – 698
40. Soliman M., Kaplan E., Guimaraes V., Yanagawa T., DeGroot L. J. T-cell recognition of residue 158–176 in thyrotropin receptor confers risk for development of thyroid autoimmunity in siblings in a family with Graves' disease. Thyroid 1996; 6: 545 – 551
41. Elias D., Cohen I. R. The hsp60 peptide p277 arrests the autoimmune diabetes induced by the toxin streptozotocin. Diabetes 1996; 45: 1168 – 1172
42. Elias D., Cohen I. R. Peptide therapy for diabetes in NOD mice. Lancet 1994; 343: 704 – 706
43. Burns F. R., Li X. B., Shen N., Offner H., Chou Y. K., Vandenbark A. A., Heber Katz E. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 1989; 169: 27 – 39
44. Wucherpfennig K. W., Ota K., Endo N., Seidman J. G., Rosenzweig A., Weiner H. L., Hafler D. A. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science 1990; 248: 1016 – 1019
45. Kotzin B. L., Karuturi S., Chou Y. K., Lafferty J., Forrester J. M., Better M., Nedwin G. E., Offner H., Vandenbark A. A. Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA 1991; 88: 9161 – 9165
46. Bartels E. D. Twin examinations: heredity in Graves' disease. Munksgaard, Copenhagen, 32
47. Tomer Y., Barbesino G., Keddache M., Greenberg D. A., Davies T. F. Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31. J. Clini. Endocrinol. Metab. 1997; 82: 1645 – 1648
48. Farid N. R. Immunogenetics of autoimmune thyroid disorders. Endocrinol. Metab. Clin. North Am. 1987; 16: 229 – 245
49. Tomer Y., Davies T. F. Infection, thyroid disease, and autoimmunity. Endocr. Rev. 1993; 14: 107 – 120
50. Demaine A., Welsh K. I., Hawe B. S., Farid N. R. Polymorphism of the T cell receptor beta-chain in Graves' disease. J. Clin. Endocrinol. Metab. 1987; 65: 643 – 646
51. Weetman A. P., So A. K., Roe C., Walport M. J., Foroni L. T-cell receptor alpha chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' disease. Hum. Immunol. 1987; 20: 167 – 173
52. Demaine A. G., Ratanachaiyavong S., Pope R., Ewins D., Millward B. A., McGregor A. M. Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci. Clin. Exp. Immunol. 1989; 77: 21 – 24
53. Mangklabruks A., Cox N., DeGroot L. J. Genetic factors in autoimmune thyroid disease analyzed by restriction fragment length polymorphisms of candidate genes. J. Clin. Endocrinol. Metab. 1991; 73: 236 – 244
54. Weetman A. P., So A. K., Warner C. A., Foroni L., Fells P., Shine B. Immunogenetics of Graves' ophthalmopathy. Clin. Endocrinol. Oxf. 1988; 28: 619 – 628
55. Martin A., Magnusson R. P., Brennan V., Kendler D. L., Davies T. F. Human thyroid peroxidase (TPO) expression in a transfected lymphoblast line (RAJI-TPO). Clin. Res. 1991; 39: 207A, Abstr
56. Martin A., Magnusson R. P., Kendler D. L., Davies T. F. Successful hTPO-antigen specific human T cell cloning via hTPO transfected and immortalized B cell lines from patients with autoimmune thyroid disease. Thyroid, 1: S – 20, Supplement 1Abstr
57. Martin A., Magnusson R. P., Kendler D. L., Concepcion E., Ben-Nun A., Davies T. F. 1993. Endogenous antigen presentation by autoantigen-transfected EBV-lymphoblastoid cells: I. Generation of human thyroid peroxidase-reactive T cells and their T-cell-receptor repertoire. J. Clin. Invest. 1991; 91: 1567 – 1574
58. Martin A., Matsuoka N., Concepcion E. S., Davies T. F. Endogenous antigen presentation by autoantigen-transfected Epstein-Barr virus-lymphoblastoid cells: T cell receptor N-region hydrophobicity relates to thyroid antigen recognition. Autoimmunity 1995; 21: 223 – 230
59. Nossal G. J. Negative selection of lymphocytes. Cell 1994; 76: 229 – 239
60. Kaye J., Kersh G., Engel I., Hedrick S. M. Structure and specificity of the T cell antigen receptor. Semin. Immunol. 1994; 3: 269 – 280
61. Chien Y., Davis M. M. How αβ T-cell receptors ‘see’ peptide/MHC complexes. Immunology Today 1993; 14: 597 – 602
62. Tanford C. The hydrophobic effect and the organization of living matter. Science 1978; 200: 1012 – 1018
63. Casali P., Burastero S. E., Nakamura M., Inghirami G., Notkins A. L. Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1 + B-cell subset. Science 1987; 236: 77 – 81
64. Casali P., Notkins A. L. Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu. Rev. Immunol. 1989; 7: 513 – 535
65. Martin T., Crouzier R., Weber J. C., Kipps T. J., Pasquali J. L. Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J. Immunol. 1994; 152: 5988 – 5996
66. Genain C. P., Lee D., Parritz M., Nguyen H., Massacesi L., Joshi N., Ferrante R., Hoffman K., Moseley M., Letvin N., Hauser S. L. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 1994; 94: 1339 – 1345
67. Tandon N., Freeman A., Weetman A. P. T cell responses to synthetic TSH receptor peptides in Graves' disease. Clin. Exp. Immunol. 1992; 89: 468 – 473
68. Corr M., Slanetz A. E., Boyd L. F., Jelonek M. T., Khilko S., Al B. K., Kim-Ramadi Y. S., Maher S. E., Bothwell A. L.M., Margulies D. H. T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science 1994; 265: 946 – 949
69. Mullins R. J., Chernajovsky Y., Dayan C., Londei M., Feldmann M. Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells. J. Immunol. 1994; 152: 5572 – 5580
70. Garcia K. C., Degano M., Stanfield R. L., Brunmark A., Jackson M. R., Peterson P. A., Teyton L., Wilson I. A. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 1996; 274: 209 – 219
71. Giordano C., Stassi G., De Maria R., Todaro M., Richiusa P., Papoff G., Ruberti G., Bagnasco M., Testi R., Galluzzo A. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 1997; 275: 960 – 963
72. Dijkstra C. D., Dopp E. A., Huitinga I., Damoiseaux J. G. Macrophages in experimental autoimmune diseases in the rat: a review. Curr. Eye Res., 11 (Suppl) 75 – 79
73. Nakashima M., Kong Y. M., Davies T. F. The role of T cells expressing TcR V beta 13 in autoimmune thyroiditis induced by transfer of mouse thyroglobulin-activated lymphocytes: identification of two common CDR3 motifs. Clin. Immunol. Immunopathol. 1992; 80: 204 – 210
74. Martin A., Nakashima M., Zhou A., Aronson D., Werner A. J., Davies T. F. Detection of major T-cell epitopes on the human TSH receptor by overriding immune heterogeneity in patients with Graves' disease. Journal of Clinical Endocrinology and Metabolism 1997, in press
75. Martin A., Matsuoka N., Zhang J., Zhou A., Nakashima M., Unger P., Schwartz A. E., Friedman E. W., Shultz L. D., Davies T. F. Preservation of functioning human thyroid “organoids” in the scid mouse: IV. In vivo selection of an intrathyroidal T-cell repertoire. Endocrinology 1997, in press