Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme

Peptides

Volumn 27, Issue 7, 2006, Pages 1693-1700

  Paradis Bleau, Catherine ^a   Beaumont, Mélanie ^a   Boudreault, Lydia ^a   Lloyd, Adrian ^b   Sanschagrin, François ^a   Bugg, Timothy D H ^b   Levesque, Roger C ^a  

^a CREFSIP   (Canada)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Inhibitory peptides; MurD; Phage display; Pseudomonas aeruginosa; UDP N acetylmuramyl l alanine:d glutamate ligase

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AMINO ACID; BACTERIAL DNA; GLUTAMIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIGASE; LIGASE INHIBITOR; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMYLALANYL DEXTRO GLUTAMATE LIGASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL CELL WALL; CONSENSUS; DNA SEQUENCE; DRUG BINDING SITE; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENE LIBRARY; GENETIC CODE; GENETIC CONSERVATION; GENETIC SCREENING; IC 50; LINEAR SYSTEM; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; SPECTROPHOTOMETRY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; LIGASES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

EID: 33744983912     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.01.017     Document Type: Article

References (35)

1. Antane S., Caufield C.E., Hu W., Keeney D., Labthavikul P., Morris K., et al. Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett 16 (2006) 176-180
2. Bertrand J.A., Fanchon E., Martin L., Chantalat L., Auger G., Blanot D., et al. "Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase. J Mol Biol 301 (2000) 1257-1266
3. Bouhss A., Dementin S., Parquet C., Mengin-Lecreulx D., Bertrand J.A., Le Beller D., et al. Role of the ortholog and paralog amino acid invariants in the active site of the UDP-MurNAc-l-alanine:d-glutamate ligase (MurD). Biochemistry 38 (1999) 12240-12247
4. Burns K.L., and May S.W. Separation methods applicable to the evaluation of enzyme-inhibitor and enzyme-substrate interactions. J Chromatogr B Analyt Technol Biomed Life Sci 797 (2003) 175-190
5. Carettoni D., Gomez-Puertas P., Yim L., Mingorance J., Massidda O., Vicente M., et al. Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA. Proteins 50 (2003) 192-206
6. Christensen D.J., Gottlin E.B., Benson R.E., and Hamilton P.T. Phage display for target-based antibacterial drug discovery. Drug Discov Today 6 (2001) 721-727
7. Collet J.F., and Bardwell J.C. Oxidative protein folding in bacteria. Mol Microbiol 44 (2002) 1-8
8. Dathe M., and Wieprecht T. Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells. Biochim Biophys Acta 1462 (1999) 71-87
9. Delgado M.L., Gil M.L., and Gozalbo D. Starvation and temperature upshift cause an increase in the enzymatically active cell wall-associated glyceraldehyde-3-phosphate dehydrogenase protein in yeast. FEMS Yeast Res 4 (2003) 297-303
10. El Zoeiby A., Sanschagrin F., Darveau A., Brisson J.R., and Levesque R.C. Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries. J Antimicrob Chemother 51 (2003) 531-543
11. El Zoeiby A., Sanschagrin F., Havugimana P.C., Garnier A., and Levesque R.C. In vitro reconstruction of the biosynthetic pathway of peptidoglycan cytoplasmic precursor in Pseudomonas aeruginosa. FEMS Microbiol Lett 201 (2001) 229-235
12. El Zoeiby A., Sanschagrin F., and Levesque R.C. Structure and function of the Mur enzymes: development of novel inhibitors. Mol Microbiol 47 (2003) 1-12
13. Fischer P.M., Krausz E., and Lane D.P. Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation. Bioconjug Chem 12 (2001) 825-841
14. Geer L.Y., Domrachev M., Lipman D.J., and Bryant S.H. CDART: protein homology by domain architecture. Genome Res 12 (2002) 1619-1623
15. Hoess R.H. Protein design and phage display. Chem Rev 101 (2001) 3205-3218
16. Hoiby N. Understanding bacterial biofilms in patients with cystic fibrosis: current and innovative approaches to potential therapies. J Cyst Fibros 1 (2002) 249-254
17. Horton J.R., Bostock J.M., Chopra I., Hesse L., Phillips S.E., Adams D.J., et al. Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD. Bioorg Med Chem Lett 13 (2003) 1557-1560
18. Hyde-DeRuyscher R., Paige L.A., Christensen D.J., Hyde-DeRuyscher N., Lim A., Fredericks Z.L., et al. Detection of small-molecule enzyme inhibitors with peptides isolated from phage-displayed combinatorial peptide libraries. Chem Biol 7 (2000) 17-25
19. Levy S.B., and Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10 (2004) S122-S129
20. Ma Y., Stern R.J., Scherman M.S., Vissa V.D., Yan W., Jones V.C., et al. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45 (2001) 1407-1416
21. Mesyanzhinov V.V., Robben J., Grymonprez B., Kostyuchenko V.A., Bourkaltseva M.V., Sykilinda N.N., et al. The genome of bacteriophage phiKZ of Pseudomonas aeruginosa. J Mol Biol 317 (2002) 1-19
22. Modun B., Morrissey J., and Williams P. The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions. Trends Microbiol 8 (2000) 231-237
23. Nefzi A., Dooley C., Ostresh J.M., and Houghten R.A. Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds. Bioorg Med Chem Lett 8 (1998) 2273-2278
24. Pancholi V., and Chhatwal G.S. Housekeeping enzymes as virulence factors for pathogens. Int J Med Microbiol 293 (2003) 391-401
25. Paradis-Bleau C., Sanschagrin F., and Levesque R.C. Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials. J Antimicrob Chemother 54 (2004) 278-280
26. Paradis-Bleau C., Sanschagrin F., and Levesque R.C. Peptide inhibitors of the essential cell division protein FtsA. Protein Eng Des Sel 18 (2005) 85-91
27. Pierce G.E. Pseudomonas aeruginosa, Candida albicans, and device-related nosocomial infections: implications, trends, and potential approaches for control. J Ind Microbiol Biotechnol 32 (2005) 309-318
28. Projan S.J. New (and not so new) antibacterial targets-from where and when will the novel drugs come?. Curr Opin Pharmacol 2 (2002) 513-522
29. Reddy S.G., Waddell S.T., Kuo D.W., Wong K.K., and Pompliano D.L. Preparative enzymatic synthesis and characterization of the cytoplasmic intermediates of murein biosynthesis. J Am Chem Soc 121 (1999) 1175-1178
30. Savoie A., Sanschagrin F., Palzkill T., Voyer N., and Levesque R.C. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng 13 (2000) 267-274
31. Shai Y., and Oren Z. From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides. Peptides 22 (2001) 1629-1641
32. Silver L.L. Novel inhibitors of bacterial cell wall synthesis. Curr Opin Microbiol 6 (2003) 431-438
33. Strancar K., Blanot D., and Gobec S. Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD. Bioorg Med Chem Lett 16 (2006) 343-348
34. Walsh A.W., Falk P.J., Thanassi J., Discotto L., Pucci M.J., and Ho H.T. Comparison of the d-glutamate-adding enzymes from selected Gram-positive and Gram-negative bacteria. J Bacteriol 181 (1999) 5395-5401
35. Young K.D. Bacterial shape. Mol Microbiol 49 (2003) 571-580