Effect of the aqueous component of the mobile phase on RP-TLC retention and its implication in the determination of lipophilicity for a series of structurally diverse drugs

Journal of Planar Chromatography - Modern TLC

Volumn 19, Issue 108, 2006, Pages 151-156

  Giaginis, Costas ^a   Dellis, Demetris ^a   Tsantili Kakoulidou, Anna ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Effect of buffer; Ionization correction; Lipophilicity; Morpholinepropanesulfonic acid; n Decylamine; Phospate buffer; Phospate buffered saline; RP TLC

Indexed keywords

ACIDS; DRUG PRODUCTS; IONIZATION; METHANOL; PH; PHOSPHATES;

IONIZATION CORRECTION; LIPOPHILICITY; MORPHOLINEPROPANESULFONIC ACID; PHOSPHATE BUFFER; PHOSPHATE-BUFFERED SALINE;

THIN LAYER CHROMATOGRAPHY;

AMITRIPTYLINE; BUFFER; CHLORPROMAZINE; DECYLAMINE; DILTIAZEM; FLUOXETINE; METHANOL; MORPHOLINE DERIVATIVE; NIFEDIPINE; NIMESULIDE; NORFLUOXETINE; PHENAZINE; PHOSPHATE; PINDOLOL; PROMETHAZINE; PROPANE; PROPRANOLOL; PROTRIPTYLINE; SULFONIC ACID DERIVATIVE; TIOCONAZOLE; TRIMETHOPRIM;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG STRUCTURE; INTERMETHOD COMPARISON; IONIZATION; LIPOPHILICITY; MATHEMATICAL MODEL; PH; PLOTS AND CURVES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVERSED PHASE THIN LAYER CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

EID: 33744959343     PISSN: 09334173     EISSN: None     Source Type: Journal    
DOI: 10.1556/JPC.19.2006.2.12     Document Type: Article

References (21)

1. C. Hansch and A. Leo, Exploring QSAR: Fundamentals and Applications in Chemistry and Biology, American Chemical Society, Washington DC, 1995.
2. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Freeney, Adv. Drug. Deliv. Rev. 23 (1997) 3-25.
3. J. Sangster, Octanol-Water Partition Coefficients: Fundamentals and Physical Chemistry, Wiley Series in Solution Chemistry, Vol. 2 Wiley, New York, 1997.
4. G.L. Biagi, M.C. Barbaro, A. Sapone, and M, Recanatini, J. Chromatogr. A 662 (1994) 341-361.
5. J.G. Dorsey and M.G. Khaledi, J. Chromatogr. A 656 (1993) 485-499.
6. A. Bechalany, A. Tsantili-Kakoulidou, N. El Tayar, and B. Testa, J. Chromatogr. 541 (1991) 221-229.
7. F. Lombardo, M.Y. Shalaeva, K.A. Tupper, and F. Gao, J. Med. Chem. 44 (2001) 2490-2497.
8. D. Vrakas, I. Panderi, D. Hadjipavlou-Litina, and A. Tsantili-Kakoulidou, Quant. Struct.-Act. Relat. 24 (2005) 254-269.
9. K.P. Dross, R. Mannhold, and R.F. Rekker, Quant. Struct.-Act. Relat. 11 (1992) 36-44.
10. I Panderi, Ch. Angelopoulos, A. Tsantili-Kakoulidou, M. Kazanis, and A. Vavayiannis, Il Farmaco 52 (1997) 167-172.
11. B. Malawska, J. Planar Chromatogr. 11 (1998) 137-140.
12. B. Malawska, K. Kulig, and M. Wiśniewska, J. Planar Chromatogr. 13 (2000) 187-190.
13. S. Unger and G. Chiang, J. Med. Chem. 24 (1981) 262-270.
14. K. Valko, S. Nunhuck, C. Beran, M. Abraham, and D. Reynolds, J. Pharm. Sci. 92 (2003) 2236-2248.
15. A.C. Moffat, Comprehensive Medicinal Chemistry, Vol. 6, Pergamon Press, Oxford, UK, 1990.
16. N. Gulyaeva, A. Zaslavsky, P. Lechner, M. Chlenov, O. McConnell, A. Chait, V. Kipnis, and B. Zalslavsky, Eur. J. Med. Chem. 38 (2003) 391-396.
17. D. Vrakas, A. Tsantili-Kakoulidou, and D. Hadjipavlou-Litina, Quant. Struct.-Act. Relat. 22 (2003) 622-629.
18. J.K. Rózyło, A. Niewiadomy, A. Zabińska, and J. Martysiak, J. Planar Chromatogr. 11 (1998) 450-459.
19. G.L. Biagi, A.M Barbaro, A. Sapone, P.A. Borea, K. Varani, and M. Rekanatini, J. Chromatogr. 723 (1996) 135-143.
20. F. Barbato, M.I. La Rotonda, and F. Quaglia, Eur. J. Med. Chem. 31 (1996) 311-318.
21. D. Reymond, G.N. Chung, J.M Mayer, and B. Testa, J. Chromatogr. 391(1987) 97-109.