Chemical modification of santonin into a diacetoxy acetal form confers the ability to induce differentiation of human promyelocytic leukemia cells via the down-regulation of NF-κB DNA binding activity

Journal of Biological Chemistry

Volumn 281, Issue 19, 2006, Pages 13117-13125

  Seung, Hyun Kim ^a   Ju, Han Song ^b   Bo, Gil Choi ^b   Kim, Hyeoung Joon ^c   Tae, Sung Kim ^a,c  

^a Korea University   (South Korea)

^b Chonnam National University   (South Korea)

^c Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; DISEASES; DNA; SYNTHESIS (CHEMICAL);

GRANULOCYTIC LINEAGE; HUMAN PROMYELOCYTIC LEUKEMIA; LACTONE COMPOUNDS; LEUKEMIA CELLS;

CELLS;

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 OXOEUDESMANO 13,6 LACTONE; 3,3 (ETHYLENEDIOXY)EUDESMANO 13,6 DIACETATE; 3,3 (ETHYLENEDIOXY)EUDESMANO 13,6 DIOL; 3,3 (ETHYLENEDIOXY)EUDESMANO 13,6 LACTONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHELERYTHRINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SANTONIN; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; GRANULOCYTE; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL DIFFERENTIATION; DNA; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GRANULOCYTE PRECURSOR CELLS; HL-60 CELLS; HUMANS; LEUKEMIA; MOLECULAR STRUCTURE; NF-KAPPA B; PROTEIN BINDING; PROTEIN KINASE C; SANTONIN;

EID: 33744957352     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510944200     Document Type: Article

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