A retinoic acid receptor β/γ-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation

Molecular Pharmacology

Volumn 66, Issue 6, 2004, Pages 1727-1737

  Yen, Andrew ^a   Fenning, Robert ^a   Chandraratna, Roshantha ^b   Walker, Patricia ^b   Varvayanis, Susi ^a  

^a Department of Obstetrics Gynecology   (United States)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PRODRUG; RETINOBLASTOMA PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR; TAZAROTENE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BONE MARROW CELL; CARCINOGENICITY; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KINETICS; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

CELL DIFFERENTIATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G0 PHASE; HL-60 CELLS; HUMANS; KINETICS; LIGANDS; NICOTINIC ACIDS; PHOSPHORYLATION; PRODRUGS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS);

EID: 9444267734     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.003475     Document Type: Article

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