Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation

Biochemical Pharmacology

Volumn 72, Issue 2, 2006, Pages 256-266

  Oleinik, Natalia V ^a   Krupenko, Natalia I ^a   Reuland, Steven N ^a   Krupenko, Sergey A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

A549 cells; DHFR; Enzyme product inhibition; FDH; Folate; Growth suppressor; Leucovorin; Resistance mechanism

Indexed keywords

10 FORMYLTETRAHYDROFOLIC ACID; DIHYDROFOLATE REDUCTASE; ENZYME; FOLIC ACID; FOLIC ACID DERIVATIVE; FOLINIC ACID; FORMYLTETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL CYCLE S PHASE; CHEMICAL REACTION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; STATISTICAL SIGNIFICANCE; UPREGULATION;

BASE SEQUENCE; CATALYSIS; CELL LINE; DNA PRIMERS; DRUG RESISTANCE; FOLIC ACID; HUMANS; LEUCOVORIN; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; TETRAHYDROFOLATE DEHYDROGENASE; UP-REGULATION;

EID: 33744902118     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.04.005     Document Type: Article

References (42)

1. Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey L.B. (Ed). Folate in health and disease (1995), Marcel Dekker Inc., New York 23-42
2. Kisliuk R.L. Folate biochemistry in relation to antifolate selectivity. In: Jackman A.L. (Ed). Antifolate drugs in cancer therapy (1999), Humana Press, Totowa, New Jersey 13-36
3. Nijhout H.F., Reed M.C., Budu P., and Ulrich C.M. A mathematical model of the folate cycle: new insights into folate homeostasis. J Biol Chem 279 53 (2004) 55008-55016
4. Suh J.R., Herbig A.K., and Stover P.J. New perspectives on folate catabolism. Annu Rev Nutr 21 (2001) 255-282
5. Stover P.J., and Garza C. Bringing individuality to public health recommendations. J Nutr 132 Suppl 8 (2002) 2476S-2480S
6. Choi S.W., and Mason J.B. Folate and carcinogenesis: an integrated scheme. J Nutr 130 2 (2000) 129-132
7. Pentieva K., McNulty H., Reichert R., Ward M., Strain J.J., McKillop D.J., et al. The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men. J Nutr 134 3 (2000) 580-585
8. Wright A.J., Finglas P.M., Dainty J.R., Wolfe C.A., Hart D.J., Wright D.M., et al. Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of the primary site of PteGlu metabolism in humans. J Nutr 135 3 (2005) 619-623
9. Flombaum C.D., and Meyers P.A. High-dose leucovorin as sole therapy for methotrexate toxicity. J Clin Oncol 17 5 (1999) 1589-1594
10. Chu E., Allegra C.J., and Antifolates. In: Chabner B.A., and Longo D.L. (Eds). Cancer chemotherapy and biotherapy: principles and practice (1996), Lippincott-Raven Publishers, Philadelphia 109-148
11. Beardsley G.P., Moroson B.A., Taylor E.C., and Moran R.G. A new folate antimetabolite 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. J Biol Chem 264 1 (1989) 328-333
12. Mendelsohn L.G.W.J.F., and Walling J.M. Preclinical and clinical evaluation of the glycinamide ribonucleotide formyltransferase inhibitors Lometrexol and LY309887. In: Jackman A.L. (Ed). Antifolate drugs in cancer therapy (1999), Humana Press, Totowa, New Jersey 261-280
13. Min H., Shane B., and Stokstad E.L. Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol. Biochim Biophys Acta 967 3 (1988) 348-353
14. Oleinik N.V., Krupenko N.I., Priest D.G., and Krupenko S.A. Cancer cells activate p53 in response to FDH expression. Biochem J (2005)
15. Krupenko S.A., and Oleinik N.V. 10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells. Cell Growth Differ 13 5 (2002) 227-236
16. Kim D.W., Huang T., Schirch D., and Schirch V. Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase. Biochemistry 35 49 (1996) 15772-15783
17. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes Memorial Lecture. Cancer Res 43 8 (1983) 3466-3492
18. Oleinik N.V., and Krupenko S.A. Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in a549 cells induces g(1) cell cycle arrest and apoptosis. Mol Cancer Res 1 8 (2003) 577-588
19. Istfan N.W., Chen Z.Y., and Rex S. Fish oil slows S phase progression and may cause upstream shift of DHFR replication origin ori-beta in CHO cells. Am J Physiol Cell Physiol 283 4 (2002) C1009-C1024
20. Priest D.G., Schmitz J.C., Bunni M.A., and Stuart R.K. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J Natl Cancer Inst 83 24 (1991) 1806-1812
21. Krupenko S.A., Wagner C., and Cook R.J. Cysteine 707 is involved in the dehydrogenase activity site of rat 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 270 2 (1995) 519-522
22. Copeland R.A. Enzymes. A practical introduction to structure, mechanism, and data analysis (2000), Wiley-VCH Inc., New York
23. Steel G.G. Growth kinetics of tumors (1977), Clarendon Press, Oxford
24. Lu X., Errington J., Chen V.J., Curtin N.J., Boddy A.V., and Newell D.R. Cellular ATP depletion by LY309887 as a predictor of growth inhibition in human tumor cell lines. Clin Cancer Res 6 1 (2000) 271-277
25. Biswas S.K., Yamaguchi M., Naoe N., Takashima T., and Takeo K. Quantitative three-dimensional structural analysis of Exophiala dermatitidis yeast cells by freeze-substitution and serial ultrathin sectioning. J Electron Microsc (Tokyo) 52 2 (2003) 133-143
26. Priest D.G., Bunni M., and Sirotnak F.M. Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo. Cancer Res 49 15 (1989) 4204-4209
27. Horne D.W. High-performance liquid chromatographic measurement of 5,10-methylenetetrahydrofolate in liver. Anal Biochem 297 2 (2001) 154-159
28. Krupenko S.A., Wagner C., and Cook R.J. Recombinant 10-formyltetrahydrofolate dehydrogenase catalyzes both dehydrogenase and hydrolase reactions utilizing the synthetic substrate 10-formyl-5,8-dideazafolate. Biochem J 306 Pt 3 (1995) 651-655
29. Banerjee D., Mayer-Kuckuk P., Capiaux G., Budak-Alpdogan T., Gorlick R., and Bertino J.R. Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochim Biophys Acta 1587 2-3 (2002) 164-173
30. Nicolson G.L. Gene expression, cellular diversification and tumor progression to the metastatic phenotype. Bioessays 13 7 (1991) 337-342
31. Asai S., Miyachi H., Kobayashi H., Takemura Y., and Ando Y. Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin. Cancer Sci 94 2 (2003) 210-214
32. Anguera M.C., Suh J.R., Ghandour H., Nasrallah I.M., Selhub J., and Stover P.J. Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J Biol Chem 278 32 (2003) 29856-29862
33. Boarman D.M., Baram J., and Allegra C.J. Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. Biochem Pharmacol 40 12 (1990) 2651-2660
34. Bunni M.A., Sirotnak F.M., Otter G.M., and Priest D.G. Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice. Cancer Chemother Pharmacol 34 6 (1994) 455-458
35. Raghunathan K., and Priest D.G. Modulation of fluorouracil antitumor activity by folic acid in a murine model system. Biochem Pharmacol 58 5 (1999) 835-839
36. Schirch V., and Strong W.B. Interaction of folylpolyglutamates with enzymes in one-carbon metabolism. Arch Biochem Biophys 269 2 (1989) 371-380
37. Matherly L.H., and Muench S.P. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells. Biochem Pharmacol 39 12 (1990) 2005-2014
38. Slansky J.E., and Farnham P.J. Transcriptional regulation of the dihydrofolate reductase gene. Bioessays 18 1 (1996) 55-62
39. Chu E., Takimoto C.H., Voeller D., Grem J.L., and Allegra C.J. Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. Biochemistry 32 18 (1993) 4756-4760
40. Ercikan E., Banerjee D., Waltham M., Schnieders B., Scotto K.W., and Bertino J.R. Translational regulation of the synthesis of dihydrofolate reductase. Adv Exp Med Biol 338 (1993) 537-540
41. Magro P.G., Russo A.J., Li W.W., Banerjee D., and Bertino J.R. p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with non-functional p53. Cancer Res 64 12 (2004) 4338-4345
42. Schmitz J.C., Liu J., Lin X., Chen T.M., Yan W., Tai N., et al. Translational regulation as a novel mechanism for the development of cellular drug resistance. Cancer Metast Rev 20 1-2 (2001) 33-41