Modulation of fluorouracil antitumor activity by folic acid in a murine model system

Biochemical Pharmacology

Volumn 58, Issue 5, 1999, Pages 835-839

  Raghunathan, Kamasamudram ^a   Priest, David G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Dietary folate depletion; Fluorouracil; Folic acid; Mammary adenocarcinoma; Mouse model

Indexed keywords

DRUG METABOLITE; FLUOROURACIL; FOLIC ACID; METHYLENETETRAHYDROFOLIC ACID; TETRAHYDROFOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENTIATION; DRUG TISSUE LEVEL; FEMALE; FOLIC ACID DEFICIENCY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; ANTIDOTES; ANTIMETABOLITES, ANTINEOPLASTIC; DIET; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FLUOROURACIL; FOLIC ACID; FOLIC ACID DEFICIENCY; LEUCOVORIN; MICE; MICE, INBRED C3H; NEOPLASMS, EXPERIMENTAL;

EID: 0032788378     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00157-4     Document Type: Article

References (18)

1. Mini E., Trave F., Rustum Y.M., Bertino J.R. Enhancement of the antitumor effects of 5-fluorouracil by folinic acid. Pharmacol Ther. 47:1990;1-19.
2. Buroker T.R., O'Connell M.J., Wieand S., Krook J.E., Geersfner J.B., Mailliard J.A., Schaefer P.L., Levitt R., Kardinal C.G., Gesme D.H. Jr. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol. 12:1994;14-20.
3. Trave F., Rustum Y.M., Petrelli N.J., Herrera L., Mittleman A., Frank C., Creacen P.J. Plasma and tumor tissue pharmacology of intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma. J Clin Oncol. 6:1988;1184-1191.
4. Danenberg P.V., Danenberg K.D. Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthase Evidence for an ordered mechanism . Biochemistry. 17:1978;4018-4024.
5. Dohden K., Ohmura K., Watanabe Y. Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues. Cancer. 71:1993;471-480.
6. Wright J.E., Pardo M., Sayeed-Shah U., Alperin W., Rosowsky A. Leucovorin and folic acid regimens for selective expansion of murine 5,10-methylenetetrahydrofolate pools. Biochem Pharmacol. 49:1995;677-685.
7. Schmitz J.C., Stuart R.K., Priest D.G. Disposition of folic acid and its metabolites A comparison with leucovorin . Clin Pharmacol Ther. 55:1994;501-508.
8. Raghunathan K., Schmitz J.C., Priest D.G. Impact of schedule on leucovorin potentiation of fluorouracil antitumor activity in dietary folic acid deplete mice. Biochem Pharmacol. 53:1997;1197-1202.
9. Raghunathan K., Schmitz J.C., Priest D.G. Disposition of leucovorin and its metabolites in dietary folic acid-deplete mice - Comparison between tumor, liver and plasma. Cancer Chemother Pharmacol. 40:1997;126-130.
10. Pinter K., Davisson V.J., Santi D.V. Cloning, sequencing, and expression of the Lactobacillus casei thymidylate synthase gene. DNA. 7:1988;235-241.
11. Matthews R.G. Methylenetetrahydrofolate reductase from pig liver. Methods Enzymol. 122:1986;372-381.
12. Rios-Orlandi E.M., Zarkadas C.G., MacKenzie R.E. Formyltetrahydrofolate dehydrogenase-hydrolase from pig liver Simultaneous assay of the activities . Biochim Biophys Acta. 871:1986;24-35.
13. Nadal J.C., Van Groeningen C.J., Pinedo H.M. In vivo potentiation of 5-flurouracil by leucovorin in a murine colon carcinoma. Biomed Pharmacother. 42:1988;387-393.
14. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
15. Priest D.G., Schmitz J.C., Bunni M.A., Stuart R.K. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J Natl Cancer Inst. 83:1991;1806-1812.
16. Liu Y., Raghunathan K., Hill C., He Y., Bunni M.A., Barredo J., Priest D.G. Effects of antisense-based folylpoly-γ-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells. Biochem Pharmacol. 55:1998;2031-2037.
17. Radpavar S., Houghton P.J., Houghton J.A. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5′-fluoro-2′-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Biochem Pharmacol. 38:1989;335-342.
18. Sur P., Priest D.G., Doig M.T. Effects of growth rate and methotrexate on folate polyglutamates and folylpolyglutamate hydrolase activity in Krebs ascites cells. Biochem Cell Biol. 64:1986;363-367.