메뉴 건너뛰기




Volumn 9, Issue 1, 1999, Pages 113-121

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1

Author keywords

Chemoprotection; DT diaphorase; Genotype; NAD(P)H:quinone oxidoreductase (NQO1); Phenotype; Polymorphism

Indexed keywords

COMPLEMENTARY DNA; PROLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SERINE;

EID: 0032891702     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199902000-00015     Document Type: Article
Times cited : (217)

References (40)
  • 1
    • 0028243181 scopus 로고
    • Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases
    • Beall HD, Mulcahy RT, Siegel D, Traver RD, Gibson NW, Ross D. Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases. Cancer Res 1994; 54:3196-3201.
    • (1994) Cancer Res , vol.54 , pp. 3196-3201
    • Beall, H.D.1    Mulcahy, R.T.2    Siegel, D.3    Traver, R.D.4    Gibson, N.W.5    Ross, D.6
  • 2
    • 0029121481 scopus 로고
    • Nicotinamide adenine dinucleotide (phosphate): Quinone oxidoreductase (DT-diaphorase) as a target for bioreductive anti-tumor quinones: Quinone cytotoxicity and selectivity in human lung and breast cancer cell lines
    • Beall HD, Murphy AM, Siegel D, Hargreaves RHJ, Butler J, Ross D. Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive anti-tumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Mol Pharmacol 1995; 48:499-504.
    • (1995) Mol Pharmacol , vol.48 , pp. 499-504
    • Beall, H.D.1    Murphy, A.M.2    Siegel, D.3    Hargreaves, R.H.J.4    Butler, J.5    Ross, D.6
  • 3
    • 0019142866 scopus 로고
    • Increase of NAD(P)H: Quinone reductase by dietary antioxidants. Possible role in protection against carcinogenesis
    • Benson AM, Hunkelerm MJ, Talalay P. Increase of NAD(P)H: quinone reductase by dietary antioxidants. Possible role in protection against carcinogenesis. Proc Natl Acad Sci USA 1980; 77:5216-5220.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 5216-5220
    • Benson, A.M.1    Hunkelerm, M.J.2    Talalay, P.3
  • 5
    • 0028178833 scopus 로고
    • Expression of NAD(P)H: Quinone oxidoreductase and glutathione S-transferases a and p in human renal cell carcinoma and in kidney cancer-derived cell lines
    • Eickelmann P, Ebert T, Warskulat U, Schulz WA, Sies H. Expression of NAD(P)H: quinone oxidoreductase and glutathione S-transferases a and p in human renal cell carcinoma and in kidney cancer-derived cell lines. Carcinogenesis 1994a; 15:219-225.
    • (1994) Carcinogenesis , vol.15 , pp. 219-225
    • Eickelmann, P.1    Ebert, T.2    Warskulat, U.3    Schulz, W.A.4    Sies, H.5
  • 6
    • 0028467127 scopus 로고
    • Loss of heterozygosity at the NAD(P)H: Quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line
    • Eickelmann P, Schulz WA, Rohde D, Schmitz-Dräger B, Sies H. Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line. Biol Chem Hoppe Seyler 1994b; 375:439-445.
    • (1994) Biol Chem Hoppe Seyler , vol.375 , pp. 439-445
    • Eickelmann, P.1    Schulz, W.A.2    Rohde, D.3    Schmitz-Dräger, B.4    Sies, H.5
  • 7
    • 77957000392 scopus 로고
    • DT-diaphorase
    • Ernster L. DT-diaphorase. Meth Enzymol 1967; 10:309-317.
    • (1967) Meth Enzymol , vol.10 , pp. 309-317
    • Ernster, L.1
  • 8
    • 0019051838 scopus 로고
    • Long-term culture of human bone marrow cells
    • Gartner S, Kaplan HS. Long-term culture of human bone marrow cells. Proc Natl Acad Sci U S A 1980; 77:4756-4759.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 4756-4759
    • Gartner, S.1    Kaplan, H.S.2
  • 10
    • 9844256095 scopus 로고    scopus 로고
    • Ethnic variation in the prevalence of a common NAD(P)H: Quinone oxidoreductase polymorphism and its implications for anticancer chemotherapy
    • Kelsey KT, Wiencke JK, Christiani DC, Zuo Z. Spitz MR, Xu X, et al. Ethnic variation in the prevalence of a common NAD(P)H: quinone oxidoreductase polymorphism and its implications for anticancer chemotherapy. Br J Cancer 1997; 76:852-854.
    • (1997) Br J Cancer , vol.76 , pp. 852-854
    • Kelsey, K.T.1    Wiencke, J.K.2    Christiani, D.C.3    Zuo, Z.4    Spitz, M.R.5    Xu, X.6
  • 11
    • 0029636702 scopus 로고
    • Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer
    • Kolesar JM, Burris III HA, Kuhn JG. Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. JNCI 1995; 87:1803.
    • (1995) JNCI , vol.87 , pp. 1803
    • Kolesar, J.M.1    Burris H.A. III2    Kuhn, J.G.3
  • 12
    • 0029859863 scopus 로고    scopus 로고
    • DT-diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function
    • Landi L, Fiorentini D, Galli MC, Segura-Aguilar J. Beyer RE. DT-diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function. Free Radic Biol Med 1997; 22:329-335.
    • (1997) Free Radic Biol Med , vol.22 , pp. 329-335
    • Landi, L.1    Fiorentini, D.2    Galli, M.C.3    Segura-Aguilar, J.4    Beyer, R.E.5
  • 13
    • 0013504298 scopus 로고    scopus 로고
    • Mutation of DT-diaphorase in human breast cancer cell lines
    • Leith MK, Begleiter A. Mutation of DT-diaphorase in human breast cancer cell lines. Proc Am Assoc Cancer Res 1998; 39:2916.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 2916
    • Leith, M.K.1    Begleiter, A.2
  • 14
    • 0025142668 scopus 로고
    • DT-diaphorase. purification properties and function
    • Lind C, Cadenas E, Hochstein P, Ernster L. DT-diaphorase. purification properties and function. Meth Enzymol 1990; 186:287-301.
    • (1990) Meth Enzymol , vol.186 , pp. 287-301
    • Lind, C.1    Cadenas, E.2    Hochstein, P.3    Ernster, L.4
  • 16
    • 0026700546 scopus 로고
    • Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C
    • Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, et al. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin C. Cancer Res 1992; 52:4752-4757.
    • (1992) Cancer Res , vol.52 , pp. 4752-4757
    • Malkinson, A.M.1    Siegel, D.2    Forrest, G.L.3    Gazdar, A.F.4    Oie, H.K.5    Chan, D.C.6
  • 17
    • 0031935057 scopus 로고    scopus 로고
    • Transfection of COS-1 cells with DT-diaphorase cDNA: Role of a base change at position 609
    • Misra V, Klamut HJ, Rauth AM. Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position 609. Br J Cancer 1998; 77:1236-1240.
    • (1998) Br J Cancer , vol.77 , pp. 1236-1240
    • Misra, V.1    Klamut, H.J.2    Rauth, A.M.3
  • 18
    • 0013532549 scopus 로고    scopus 로고
    • Mechanism underlying the increased susceptibility of individuals with a polymorphism in NQO1 to benzene toxicity
    • Moran JL, Siegel D, Ross D. Mechanism underlying the increased susceptibility of individuals with a polymorphism in NQO1 to benzene toxicity. Toxicologist 1998; 42 (suppl 1):1393.
    • (1998) Toxicologist , vol.42 , Issue.SUPPL. 1 , pp. 1393
    • Moran, J.L.1    Siegel, D.2    Ross, D.3
  • 19
    • 0028833858 scopus 로고
    • NAD(P)H: Quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells
    • Pan SS, Forrest GL, Akman SA, Hu L-T. NAD(P)H: quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells. Cancer Res 1995; 55:330-335.
    • (1995) Cancer Res , vol.55 , pp. 330-335
    • Pan, S.S.1    Forrest, G.L.2    Akman, S.A.3    Hu, L.-T.4
  • 21
    • 0000028560 scopus 로고    scopus 로고
    • Quinone reductases
    • Guengerich FP, editor. New York: Pergamon
    • Ross D. Quinone Reductases. In: Guengerich FP, editor. Comprehensive toxicology: biotransformation. Vol. 3. New York: Pergamon, 1997. pp. 179-198.
    • (1997) Comprehensive Toxicology: Biotransformation , vol.3 , pp. 179-198
    • Ross, D.1
  • 22
    • 0027295491 scopus 로고
    • DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C
    • Ross D, Siegel D, Beall H, Prakash AS, Mulcahy RT, Gibson NW. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev 1993; 12:83-101.
    • (1993) Cancer Metastasis Rev , vol.12 , pp. 83-101
    • Ross, D.1    Siegel, D.2    Beall, H.3    Prakash, A.S.4    Mulcahy, R.T.5    Gibson, N.W.6
  • 23
    • 0028610410 scopus 로고
    • Bioactivation of quinones by DT-diaphorase. Molecular, biochemical and chemical studies
    • Ross D, Beall H, Traver RD, Siegel D, Phillips RM, Gibson NW. Bioactivation of quinones by DT-diaphorase. Molecular, biochemical and chemical studies. Oncoj Res 1994; 6:493-500.
    • (1994) Oncoj Res , vol.6 , pp. 493-500
    • Ross, D.1    Beall, H.2    Traver, R.D.3    Siegel, D.4    Phillips, R.M.5    Gibson, N.W.6
  • 24
    • 0030458422 scopus 로고    scopus 로고
    • Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: Identification of target cells and a potential role for modulation of apoptosis in benzene toxicity
    • Ross D, Siegel D, Schattenberg DG, Sun XMM, Moran JL. Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect 1996; 104 (suppl 6):1177-1182.
    • (1996) Environ Health Perspect , vol.104 , Issue.SUPPL. 6 , pp. 1177-1182
    • Ross, D.1    Siegel, D.2    Schattenberg, D.G.3    Sun, X.M.M.4    Moran, J.L.5
  • 25
    • 0029073531 scopus 로고
    • Identification of an NAD(P)H: Quinone oxidoreductase polymorphism and its association with lung cancer and smoking
    • Rosvold EA, McGlynn KA, Lustbader ED, Buetow KH. Identification of an NAD(P)H: quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics 1995a; 5:199-206.
    • (1995) Pharmacogenetics , vol.5 , pp. 199-206
    • Rosvold, E.A.1    McGlynn, K.A.2    Lustbader, E.D.3    Buetow, K.H.4
  • 26
    • 0029638235 scopus 로고
    • Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer
    • Rosvold EA, McGlynn KA, Lustbader ED, Buetow KH. Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. J Natl Cancer Inst. 1995b; 87:1802-1803.
    • (1995) J Natl Cancer Inst. , vol.87 , pp. 1802-1803
    • Rosvold, E.A.1    McGlynn, K.A.2    Lustbader, E.D.3    Buetow, K.H.4
  • 28
    • 0030857876 scopus 로고    scopus 로고
    • Increased frequency of a null allele for NAD(P)H: Quinone oxidoreductase in patients with urological malignancies
    • Schulz WA, Krummeck A, Rosinger I, Eickelmann P, Neuhas C, Ebert T, et al. Increased frequency of a null allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics 1997; 7:235-239.
    • (1997) Pharmacogenetics , vol.7 , pp. 235-239
    • Schulz, W.A.1    Krummeck, A.2    Rosinger, I.3    Eickelmann, P.4    Neuhas, C.5    Ebert, T.6
  • 29
    • 0030739681 scopus 로고    scopus 로고
    • The reduction of alpha-tocopherolquinone by human NAD(P)H: Quinone oxidoreductase; The role of alpha-tocopherol hydroquinone as a cellular antioxidant
    • Siegel D, Bolton EM, Burr JA, Liebler DC, Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherol hydroquinone as a cellular antioxidant. Mol Pharmacol 1997; 52:300-305.
    • (1997) Mol Pharmacol , vol.52 , pp. 300-305
    • Siegel, D.1    Bolton, E.M.2    Burr, J.A.3    Liebler, D.C.4    Ross, D.5
  • 30
    • 0000537792 scopus 로고    scopus 로고
    • Immunohistochemical staining for NAD(P)H: Quinone oxidoreductase (NQO1) in normal lung and lung tumors
    • Siegel D, Franklin WA, Ross D. Immunohistochemical staining for NAD(P)H: quinone oxidoreductase (NQO1) in normal lung and lung tumors. Proc Am Assoc Cancer Res 1998; 39:804.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 804
    • Siegel, D.1    Franklin, W.A.2    Ross, D.3
  • 31
    • 0028783332 scopus 로고
    • DT-diaphorase activity in normal and neoplastic human tissues; An indicator for sensitivity to bioreductive agents
    • Smitskamp-Wilms E, Giaccone G, Pinedo HM, Van der Laan BFAM, Peters GJ. DT-diaphorase activity in normal and neoplastic human tissues; An indicator for sensitivity to bioreductive agents. Br J Cancer 1995; 72:917-921.
    • (1995) Br J Cancer , vol.72 , pp. 917-921
    • Smitskamp-Wilms, E.1    Giaccone, G.2    Pinedo, H.M.3    Van der Laan, B.F.A.M.4    Peters, G.J.5
  • 32
    • 0028825881 scopus 로고
    • Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione -S-transferases and DT-diaphorase in the saliva of subjects who continually ingest large quantities of coffee or broccoli
    • Sreerama L, Hedge MW, Sladek NE. Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione -S-transferases and DT-diaphorase in the saliva of subjects who continually ingest large quantities of coffee or broccoli. Clin Cancer Res 1995; 1:1153-1163.
    • (1995) Clin Cancer Res , vol.1 , pp. 1153-1163
    • Sreerama, L.1    Hedge, M.W.2    Sladek, N.E.3
  • 33
    • 0020017245 scopus 로고
    • Elevation of quinone reductase activity by anticarcinogenic antioxidants
    • Talalay P, Benson AM. Elevation of quinone reductase activity by anticarcinogenic antioxidants. Adv Enzyme Regul 1981; 20:287-300.
    • (1981) Adv Enzyme Regul , vol.20 , pp. 287-300
    • Talalay, P.1    Benson, A.M.2
  • 34
    • 0001923885 scopus 로고
    • Mechanisms of induction of NAD(P)H: Quinone reductase
    • Talalay P, Prochaska HJ. Mechanisms of induction of NAD(P)H: quinone reductase. Chemica Scripta 1987; 27A:61-66.
    • (1987) Chemica Scripta , vol.27 A , pp. 61-66
    • Talalay, P.1    Prochaska, H.J.2
  • 35
    • 0026505943 scopus 로고
    • NAD(P)H: Quinone oxidoreductase gene expression in human colon carcinoma cells; Characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity
    • Traver RD, Horikoshi T, Danenberg KD, Stadlbauer THW, Danenberg PV, Ross D, Gibson NW. NAD(P)H: quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res 1992; 52:797-802.
    • (1992) Cancer Res , vol.52 , pp. 797-802
    • Traver, R.D.1    Horikoshi, T.2    Danenberg, K.D.3    Stadlbauer, T.H.W.4    Danenberg, P.V.5    Ross, D.6    Gibson, N.W.7
  • 38
    • 0031015975 scopus 로고    scopus 로고
    • Lung cancer in Mexican-Americans and African-Americans is associated with the wild type genotype of the NAD(P)H: Quinone oxidoreductase polymorphism
    • Wiencke JT. Spitz MR, McMillan A, Kelsey KT. Lung cancer in Mexican-Americans and African-Americans is associated with the wild type genotype of the NAD(P)H: quinone oxidoreductase polymorphism. Cancer Epidemiol Bio Prev 1997; 6:87-92.
    • (1997) Cancer Epidemiol Bio Prev , vol.6 , pp. 87-92
    • Wiencke, J.T.1    Spitz, M.R.2    McMillan, A.3    Kelsey, K.T.4
  • 39
    • 0000598894 scopus 로고    scopus 로고
    • Catalytic properties of a naturally occurring mutant of human NAD(P)H: Quinone oxidoreductase (DT-diaphorase). Pro 187 to Ser
    • Wu K, Deng PSK, Chen S. Catalytic properties of a naturally occurring mutant of human NAD(P)H: quinone oxidoreductase (DT-diaphorase). Pro 187 to Ser. Proc Am Assoc Cancer Res 1997; 38:3758.
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 3758
    • Wu, K.1    Deng, P.S.K.2    Chen, S.3
  • 40
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang Y, Talalay P, Cho CG, Posner GH, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 1992; 89:2399-2403.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.