CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium

Journal of Molecular Medicine

Volumn 84, Issue 6, 2006, Pages 503-512

  Quinones, Marlon P ^a,b,c   Jimenez, Fabio ^a,b   Martinez, Hernan ^a,b   Estrada, Carlos A ^a,b   Willmon, Opal ^a,b   Dudley, Molly ^a,b   Kuziel, William A ^d   Melby, Peter C ^a,b   Reddick, Robert L ^b   Ahuja, Sunil K ^a,b   Ahuja, Seema S ^a,b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d PROTEIN DESIGN LABS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; COLLAGEN TYPE 2; FREUND ADJUVANT; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE INACTIVATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN;

ANIMALS; ARTHRITIS, EXPERIMENTAL; COLLAGEN TYPE II; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, KNOCKOUT; MYCOBACTERIUM AVIUM; RECEPTORS, CHEMOKINE; TUBERCULOSIS, CUTANEOUS;

EID: 33744499432     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0039-3     Document Type: Article

References (55)

1. Rot A, Von Andrian UH (2004) Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22:891-928
2. Rossi D, Zlotnik A (2000) The biology of chemokines and their receptors. Annu Rev Immunol 18:217-242
3. Charo IF, Peters W (2003) Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation 10:259-264
4. Quinones MP, Estrada CA, Kalkonde Y, Ahuja SK, Kuziel WA, Mack M, Ahuja SS (2005) The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 83:672-681
5. Quinones MP, Ahuja SK, Jimenez F, Schaefer J, Garavito E, Rao A, Chenaux G, Reddick RL, Kuziel WA, Ahuja SS (2004) Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J Clin Invest 113:856-866
6. Bruhl H, Cihak J, Schneider MA, Plachy J, Rupp T, Wenzel I, Shakarami M, Milz S, Ellwart JW, Stangassinger M, Schlondorff D, Mack M (2004) Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells. J Immunol 172:890-898
7. Albani S, Carson DA (1996) A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol Today 17:466-470
8. Bolz DD, Weis JJ (2004) Molecular mimicry to Borrelia burgdorferi: pathway to autoimmunity? Autoimmunity 37:387-392
9. Aguas A, Esaguy N, Sunkel CE, Silva MT (1990) Cross-reactivity and sequence homology between the 65-kilodalton mycobacterial heat shock protein and human lactoferrin, transferrin, and DR beta subsets of major histocompatibility complex class II molecules. Infect Immun 58:1461-1470
10. Hogervorst EJ, Boog CJ, Wagenaar JP, Wauben MH, Van der Zee R, Van Eden W (1991) T cell reactivity to an epitope of the mycobacterial 65-kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses. Eur J Immunol 21:1289-1296
11. Leech S (1998) Molecular mimicry in autoimmune disease. Arch Dis Child 79:448-451
12. Rose NR, Mackay IR (2000) Molecular mimicry: a critical look at exemplary instances in human diseases. Cell Mol Life Sci 57:542-551
13. Wucherpfennig KW (2001) Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest 108:1097-1104
14. Benoist C, Mathis D (2001) Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2:797-801
15. Ebringer A, Rashid T, Wilson C (2003) Rheumatoid arthritis: proposal for the use of anti-microbial therapy in early cases. Scand J Rheumatol 32:2-11
16. Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S (2005) A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 201:949-960
17. Godessart N (2005) Chemokine receptors: attractive targets for drug discovery. Ann NY Acad Sci 1051:647-657
18. Koch AE (2005) Chemokines and their receptors in rheumatoid arthritis: future targets? Arthritis Rheum 52:710-721
19. Bermudez LE (1994) Immunobiology of Mycobacterium avium infection. Eur J Clin Microbiol Infect Dis 13:1000-1006
20. Inderlied CB, Kemper CA, Bermudez LE (1993) The Mycobacterium avium complex. Clin Microbiol Rev 6:266-310
21. Maricic MJ, Alepa FP (1990) Reactive arthritis after Mycobacterium avium-intracellulare infection: Poncet's disease revisited. Am J Med 88:549-550
22. Southwood TR, Gaston JS (1990) The molecular basis of Poncet's disease? Br J Rheumatol 29:491
23. Hameed K, Karim M, Islam N, Gibson T (1993) The diagnosis of Poncet's disease. Br J Rheumatol 32:824-826
24. Cuende E, Almeida V, Portu J, Aldamiz M, Erdozain MA, Vesga JC, Saracibar N (1998) Poncet's disease and papulonecrotic tuberculid in a patient infected with the human immunodeficiency virus. Arthritis Rheum 41:1884-1888
25. Escalonilla P, Esteban J, Soriano ML, Farina MC, Piqu E, Grilli R, Ramirez JR, Barat A, Martin L, Requena L (1998) Cutaneous manifestations of infection by nontuberculous mycobacteria. Clin Exp Dermatol 23:214-221
26. Bartralot R, Pujol RM, Garcia-Patos V, Sitjas D, Martin-Casabona N, Coll P, Alomar A, Castells A (2000) Cutaneous infections due to nontuberculous mycobacteria: histopathological review of 28 cases. Comparative study between lesions observed in immunosuppressed patients and normal hosts. J Cutan Pathol 27:124-129
27. Ichiki Y, Hirose M, Akiyama T, Esaki C, Kitajima Y (1997) Skin infection caused by Mycobacterium avium. Br J Dermatol 136:260-263
28. Kullavanijaya P, Sirimachan S, Surarak S (1997) Primary cutaneous infection with Mycobacterium avium intracellulare complex resembling lupus vulgaris. Br J Dermatol 136:264-266
29. Palenque E (2000) Skin disease and nontuberculous atypical mycobacteria. Int J Dermatol 39:659-666
30. Kuziel WA, Dawson TC, Quinones M, Garavito E, Chenaux G, Ahuja SS, Reddick RL, Maeda N (2003) CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis 167:25-32
31. Sato N, Ahuja SK, Quinones M, Kostecki V, Reddick RL, Melby PC, Kuziel WA, Ahuja SS (2000) CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Thl)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania mayor-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med 192:205-218
32. Sato N, Kuziel WA, Melby PC, Reddick RL, Kostecki V, Zhao W, Maeda N, Ahuja SK, Ahuja SS (1999) Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J Immunol 163:5519-5525
33. Gaupp S, Pitt D, Kuziel WA, Cannella B, Raine CS (2003) Experimental autoimmune encephalomyelitis (EAE) in CCR2 (-/-) mice: susceptibility in multiple strains. Am J Pathol 162:139-150
34. Bermudez LE, Reynolds R, Kolonoski P, Aralar P, Inderlied CB, Young LS (2003) Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice. Antimicrob Agents Chemother 47:2685-2687
35. Bertram MA, Inderlied CB, Yadegar S, Kolanoski P, Yamada JK, Young LS (1986) Confirmation of the beige mouse model for study of disseminated infection with Mycobacterium avium complex. J Infect Dis 154:194-195
36. Bermudez LE, Martinelli J, Petrofsky M, Kolonoski P, Young LS (1994) Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model. J Infect Dis 169:575-580
37. Cosma CL, Sherman DR, Ramakrishnan L (2003) The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol 57:641-676
38. Luross JA, Williams NA (2001) The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 103:407-416
39. Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163-189
40. Iking-Konert C, Ostendorf B, Sander O, Jost M, Wagner C, Joosten L, Schneider M, Hansch GM (2005) Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells. Ann Rheum Dis 64:1436-1442
41. Adams DJ, Dermitzakis ET, Cox T, Smith J, Davies R, Banerjee R, Bonfield J, Mullikin JC, Chung YJ, Rogers J, Bradley A (2005) Complex haplotypes, copy number polymorphisms and coding variation in two recently divergent mouse strains. Nat Genet 37:532-536
42. Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG (1986) Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer. J Urol 135:272-274
43. Schwartzenberg JM, Smith DD, Lindsley HB (1999) Bacillus Calmette-Guerin associated arthropathy mimicking undifferentiated spondyloarthropathy. J Rheumatol 26:933-935
44. Blumenthal DR, Zucker JR, Hawkins CC (1990) Mycobacterium avium complex-induced septic arthritis and osteomyelitis in a patient with the acquired immunodeficiency syndrome. Arthritis Rheum 33:757-758
45. Bridges MJ, McGarry F (2002) Two cases of Mycobacterium avium septic arthritis. Ann Rheum Dis 61:186-187
46. Redfern DJ, Coleridge SD, Bendall SP (2004) AIDS-related ankle arthropathy: Mycobacterium avwm-intracellulare infection. J Bone Joint Surg Br 86:279-281
47. Celis L, Vandevyver C, Geusens P, Dequeker J, Raus J, Zhang J (1997) Clonal expansion of mycobacterial heat-shock protein-reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients. Arthritis Rheum 40:510-519
48. Brodmerkel CM, Huber R, Covington M, Diamond S, Hall L, Collins R, Leffet L, Gallagher K, Feldman P, Collier P, Stow M, Gu X, Baribaud F, Shin N, Thomas B, Burn T, Hollis G, Yeleswaram S, Solomon K, Friedman S, Wang A, Xue CB, Newton RC, Scherle P, Vaddi K (2005) Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol 175:5370-5378
49. Brown CR, Blaho VA, Loiacono CM (2003) Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. J Immunol 171:893-901
50. Haringman JJGD, Smeets et al (2004) A randomized placebo controlled trial with anti-MCP1 (CCL2) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum 50:S238
51. Yang YF, Mukai T, Gao P, Yamaguchi N, Ono S, Iwaki H, Obika S, Imanishi T, Tsujimura T, Hamaoka T, Fujiwara H (2002) A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses. Eur J Immunol 32:2124-2132
52. Gao P, Zhou XY, Yashiro-Ohtani Y, Yang YF, Sugimoto N, Ono S, Nakanishi T, Obika S, Imanishi T, Egawa T, Nagasawa T, Fujiwara H, Hamaoka T (2003) The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol 73:273-280
53. Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101:746-754
54. Elsner J, Petering H, Hochstetter R, Kimmig D, Wells TN, Kapp A, Proudfoot AE (1997) The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3. Eur J Immunol 27:2892-2898
55. Plater-Zyberk C, Hoogewerf AJ, Proudfoot AE, Power CA, Wells TN (1997) Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice. Immunol Lett 57:117-120