High concentrations of tricyclic antidepressants increase intracellular Ca2+ in cultured neural cells

Neurochemical Research

Volumn 24, Issue 3, 1999, Pages 391-398

  Joshi, Preeti G ^a   Singh, Archana ^a   Ravichandra, B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Amitriptyline; Antidepressants; Desipramine; Intracellular Ca2+; PC 12 cells; U 87 MG cells

Indexed keywords

AMITRIPTYLINE; DESIPRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; DEPRESSION; DRUG BRAIN LEVEL; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL LINE; DESIPRAMINE; NEUROGLIA; NEURONS; PC12 CELLS; RATS;

ANIMALIA;

EID: 0032957269     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020937717260     Document Type: Article

References (30)

1. 2+ response is increased in blood platelets of depressed patients. Biol. Psychiatry 30:310-312.
2. Dubovsky, S. L., Christiano, J., Daniell, L. C., Franks, R., Murphy, J., Adler, L., Baker, N., and Harris, R. A. 1989. Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch. Gen. Psychiatry 46:623-638.
3. Jope, R. S., Song, L., Li, P. P., Young, L. T., Kish, S. J., Pacheco, M. A., and Warsh, J. J. 1996. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J. Neurochem. 66:2402-2409.
4. Konopka, L. M., Cooper, R., and Crayton, J. W. 1996. Serotonin-induced increases in platelet cytosolic calcium concentration in depressed, schizophrenic and substance abuse patients. Biol. Psychiatry 39:708-713.
5. Pandey, S. C., Davis, J. M., Schwertz, D. W., and Pandey, G. N. 1991. Effect of antidepressants and neuroleptics on phosphoinositide metabolism in human platelets. J. Pharmacol. Exp. Ther. 256: 1010-1018.
6. Rehavi, M., Jerushelemi, Z., Aviv, A., Laor, N., Podliszewski, E., Karp, L., Shavit, S., and Weizman, R. 1993. Interaction between antidepressants and phosphoinositide signal transduction system in human platelets. Biol. Psychiatry 33:40-44.
7. Ozawa, H., and Rasenick, M. M. 1991. Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J. Neurochem. 56:330-338.
8. Ogata, N., Yoshii, M., and Narahashi, T. 1989. Psychotropic drugs block voltage-gated ion channels in neuroblastoma cells. Brain Res. 476:140-144.
9. 2+ levels in neuronal culture. Eur. J. Pharmacol. 14: 53-57.
10. 2+ concentration in rat cortical cultured neurons. Neurosci. Lett. 146:101-104.
11. 2C receptors. Biol. Psychiatry 39:1000-1008.
12. Yamaji, T., Kagaya, A., Uchitomi, Y., Yokota, N., and Yamawaki, S. 1997. Chronic treatment with antidepressants, verapamil or lithium inhibits serotonin-induced intracellular calcium response in individual C6 rat glioma cells. Life Sci. 60:817-823.
13. Osborne, N. N. 1988. Tricyclic antidepressants, mianserine and ouabain stimulate inositol phosphate formation in vitro in rat cortical slices. Neurochem. Res. 13:105-111.
14. Dyck, L. E., and Boulton, A. A. 1989. Effect of antidepressant drugs on inositol phospholipid hydrolysis in rat cerebral cortical slices. Neurochem. Res. 14:1047-1052.
15. 2+ store by antidepressant drugs in cultured neurons of rat frontal cortex. J. Neurochem. 60:595-601.
16. 2+ signalling in cultured glioma cells. Brain Res. 597:108-113.
17. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
18. 2+ and ionic fluxes in PC12 cells treated with bradykinin. J. Biol. Chem. 263:17350-17359.
19. Berridge, M. J., Dawson, R. M. C., Downes, C. P., Heslop, J. P. and Irvine, R. F. 1983. Changes in the levels of inositol phosphates after agonist dependent hydrolysis of membrane phosphoinositides. Biochem. J. 212:473-482.
20. 2+ rise in rat C6 glioma cells. J. Neurosci. 12:1077-1085.
21. Carney, D. H., Scott, D. L., Gordon, E. A., and La Belle, E. F. 1985. Phosphoinositides in mitogenesis: Neomycin inhibits thrombin stimulated phosphoinositide turnover and initiation of cell proliferation. Cell 42:479-488.
22. Nishizuka, Y. 1992. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-613.
23. Di Virgilio, F., Milani, D., Leon, A., Meldolesi, J. and Pozzan, T. 1987. Voltage dependent activation and inactivation of calcium channels in PC12 cells. J. Biol. Chem. 262:9189-9195.
24. Wojcikiewicz, R. J. H., Tobin, A. B. and Nahorski, S. R. 1993. Desensitization of cell signalling mediated by phosphoinositidase C. Trends Pharmacol. Sci. 14:279-285.
25. Marcusson, Jo., and Ross, S. B. 1990. Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets. Psychopharmacology 102:145-155.
26. 3H-desipramine to the neuronal noradrenaline carrier of rat pheochromocytoma cells (PC-12 cells). Naunyn. Schmiedebergs Arch. Pharmacol. 334:403-411.
27. Wong, K. L., Chuang, T. Y., Bruch, R. C., and Farban, A. I. 1993. Amitriptyline inhibits neurite outgrowth in chick cerebral neurons: a possible mechanism. J. Neurobiol. 24:474-87.
28. Kamatchi, K. and Ticku, M. K. 1991. Antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal chord neurons. Brain Res. 545:59-65.
29. Stockert, M., Zeiher, L. M., and Medina, J. H. 1992. Interaction of phospholipids and free acids with antidepressant recognition binding sites in rat brain. Adv. Exp. Med. Biol. 318:325-330.
30. Krul, I. K., Sikora, J., Bure, S. P., and Fuskov, A. K. 1991. Methylated and desmethylated tricyclic antidepressants and their binding to cell membranes. Drug Metabol. Drug Interact. 9:283-291.