Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production

Blood

Volumn 97, Issue 6, 2001, Pages 1635-1643

  Perez, Lia E ^a   Rinder, Henry M ^a   Wang, Chao ^a   Tracey, Jayne B ^a   Maun, Noel ^a   Krause, Diane S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; THROMBIN;

ARTICLE; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL LINEAGE; COLONY FORMING UNIT; CONTROLLED STUDY; CORRELATION FUNCTION; FLOW CYTOMETRY; HEMATOPOIESIS; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE; THROMBOCYTE FUNCTION; THROMBOCYTOPOIESIS; XENOTRANSPLANTATION;

EID: 0035869564     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1635     Document Type: Article

References (64)

1. Human megakaryocyte progenitor cells
2. Regulation of megakaryocytopoiesis
3. Megakaryocyte differentiation events
4. The high-proliferative-potential megakaryocyte mixed (HPP-Meg-Mix) cell: A trilineage murine hematopoietic progenitor with multiple growth factor responsiveness
5. Phorbol diesters stimulate the development of an early murine progenitor cell. The burst-forming unit-megakaryocyte
6. Classes of primitive murine megakaryocytic progenitor cells
7. Ex vivo expansion of megakaryocyte progenitors: Effect of various growth factor combinations on CD34+ progenitor cells from bone marrow and G-CSF-mobilized peripheral blood
8. Fit 3 ligand, MGDF, Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF, IL-3 and IL-6
9. Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin
10. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional
11. Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro
12. Use of thrombopoietic growth factors in acute leukemia
13. Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients
14. A phase I trial of recombinant human interleukin-11 (neumega rhlL-11 growth factor) in women with breast cancer receiving chemotherapy
15. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
16. Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients
17. Ex vivo expansion of hematopoietic progenitor cells: Preliminary results in breast cancer
18. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
19. Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: Implications for evaluating human gene therapy protocols
20. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
21. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells
22. Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients
23. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
24. Engraftment of immune-deficient mice with human hematopoietic stem cells
25. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice
26. Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes
27. Long-term human hematopoiesis in the SCID-hu mouse
28. The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function
29. Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: Analysis of gene transduction of long-lived progenitors
30. Genomic organization of alpha satellite DNA on human chromosome 7: Evidence for two distinct alphoid domains on a single chromosome
31. The total marrow mass of the mouse: A simplified method of measurement
32. A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets
33. A monoclonal antibody to a membrane glycoprotein binds only to activated platelets
34. Absence of CD34 on some human SCID-repopulating cells
35. SCID mouse models of human stem cell engraftment
36. Normal and leukemic human stem cells assayed in SCID mice
37. Growth of human T-cell lineage acute leukemia in severe combined immunodeficiency (SCID) mice and non-obese diabetic SCID mice
38. Leukemic cell growth in SCID mice as a predictor of relapse in high-risk B-lineage acute lymphoblastic leukemia
39. Severe combined immunodeficient mouse models of human leukemia
40. Myeloma progenitors in the blood of patients with aggressive or minimal disease: Engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice
41. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
42. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
43. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells
44. Nonobese diabetic/severe combined immunodeficiency (NOD/ SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells
45. Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells
46. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
47. Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice
48. Multilineage engraftment in NOD/LtSz-scid/scid mice from mobilized human CD34+ peripheral blood progenitor cells
49. Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/ LtSz-scid/scid mice
50. The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: A xenotransplant model for huPBSC-initiated hematopoiesis
51. Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice
52. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood
53. Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice
54. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
55. Evidence that pluripotential stem cells form splenic colonies in humans after marrow transplantation
56. Hematopoietic stem cell tracking in vivo: A comparison of short-term and long-term repopulating cells
57. In vivo engraftment potential of clinical hematopoietic grafts
58. In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate posttransplant thrombocytopenia
59. Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide
60. Detection and quantification of transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF) release by normal human megakaryocytes
61. Effects of cytokines on platelet production from blood and marrow CD34+ cells
62. In vitro expansion of CD34+/CD41+ cells from human peripheral blood CD34+/CD41- cells: Role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors
63. Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells
64. Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: Evidence for accessory cell involvement in expansion of immature CD34+CD38- cells