ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells

International Journal of Radiation Oncology Biology Physics

Volumn 65, Issue 3, 2006, Pages 851-858

  Contessa, Joseph N ^a   Abell, Angela ^a   Valerie, Kristoffer ^a   Lin, Peck Sun ^a   Schmidt Ullrich, Rupert K ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epidermal growth factor receptor; ErbB2; ErbB3; ErbB4; Radiosensitization

Indexed keywords

CELLS; DIMERIZATION; ENZYMES; MUTAGENS; RADIOTHERAPY; SIGNALING; TUMORS;

EPIDERMAL GROWTH FACTOR RECEPTOR; ERBB2; ERBB3; ERBB4; MALIGNANT GLIOMA CELL LINES; RADIOSENSITIZATION;

ENZYME INHIBITION;

ADENOVIRUS VECTOR; ANTIGEN; CD533 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CARCINOMA; CARCINOMA CELL; CELL DAMAGE; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; ENZYME INHIBITION; EXPERIMENT; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; QUANTITATIVE ANALYSIS; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; STATISTICAL MODEL; SURVIVAL;

BREAST NEOPLASMS; CELL LINE, TUMOR; DNA DAMAGE; FEMALE; HUMANS; MUTATION; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; TRANSFECTION;

EID: 33646950759     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.02.025     Document Type: Article

References (26)

1. Soltoff S.P., Carraway III K.L., et al. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol 14 (1994) 3550-3558
2. Kim H.H., Sierke S.L., and Koland J.G. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product. J Biol Chem 269 (1994) 24747-24755
3. Carter S., Auer K.L., Reardon D.B., et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene 16 (1998) 2787-2796
4. Contessa J.N., Hampton J., Lammering G., et al. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 21 (2002) 4032-4041
5. Schmidt-Ullrich R.K., Contessa J.N., Dent P., et al. Molecular mechanisms of radiation-induced accelerated repopulation. Radiat Oncol Invest 7 (1999) 321-330
6. Huang S.M., Li J., Armstrong E.A., et al. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res 62 (2002) 4300-4306
7. Shintani S., Li C., Mihara M., et al. Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer. Int J Cancer 107 (2003) 1030-1037
8. Stea B., Falsey R., Kislin K., et al. Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 ("Iressa"). Cancer Lett 202 (2003) 43-51
9. Solomon B., Hagekyriakou J., Trivett M.K., et al. EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor. Int J Radiat Oncol Biol Phys 55 (2003) 713-723
10. Zhou H., Kim Y.S., Peletier A., et al. Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys 58 (2004) 344-352
11. Huang S.M., Bock J.M., and Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 59 (1999) 1935-1940
12. Contessa J.N., Reardon D.B., Todd D., et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res 5 (1999) 405-411
13. Lammering G., Lin P.S., Contessa J.N., et al. Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells. Int J Radiat Oncol Biol Phys 51 (2001) 775-784
14. Kashles O., Yarden Y., Fischer R., et al. A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol Cell Biol 11 (1991) 1454-1463
15. Redemann N., Holzmann B., von Ruden T., et al. Anti-oncogenic activity of signaling-defective epidermal growth factor receptor mutants. Mol Cell Biol 12 (1992) 491-498
16. Schmidt-Ullrich R.K., Contessa J.N., Lammering G., et al. ERBB receptor tyrosine kinases and cellular radiation responses. Oncogene 22 (2003) 5855-5865
17. Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110 (2002) 669-672
18. Lammering G., Hewit T.H., Hawkins W.T., et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. J Natl Cancer Inst 93 (2001) 921-929
19. Ferguson K.M., Darling P.J., Mohan M.J., et al. Extracellular domains drive homo- but not hetero-dimerization of ErbB receptors. EMBO J 19 (2000) 4632-4643
20. Contessa J.N., Abell A., Mikkelsen R.B., et al. Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation. Breast Cancer Res Treat 95 (2006) 17-27
21. Valerie K., Brust D., Farnsworth J., et al. Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir. Cancer Gene Ther 7 (2000) 879-884
22. Reardon D.B., Contessa J.N., Mikkelsen R.B., et al. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene 18 (1999) 4756-4766
23. Bowers G., Reardon D., Hewitt T., et al. The relative role of Erb-B1-4 RTKs in radiation signal transduction of human carcinoma cells. Oncogene 20 (2001) 1388-1397
24. Schmidt-Ullrich R.K., Mikkelsen R.B., Dent P., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15 (1997) 1191-1197
25. Rusnak D.W., Lackey K., Affleck K., et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 1 (2001) 85-94
26. Iyer R., Thames H.D., Tealer J.R., et al. Effect of reduced EGFR function on the radiosensitivity and proliferative capacity of mouse jejunal crypt clonogens. Radiother Oncol 72 (2004) 283-289