The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

Nature

Volumn 441, Issue 1, 2006, Pages 115-119

  Helenius, Jonne ^a   Brouhard, Gary ^a   Kalaidzidis, Yannis ^a,b   Diez, Stefan ^a   Howard, Jonathon ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; DEPOLYMERIZATION; HYDROLYSIS; REACTION KINETICS; SUBSTRATES; BIOASSAY; CATALYSIS; CRYSTAL LATTICES; CYTOLOGY; DNA; NEUROLOGY; PROTEINS;

BINDING SITES; CYTOSKELETON; KINESIN; LATTICE DIFFUSION; MICROTUBULE CYTOSKELETONS; MOTOR PROTEINS; SINGLE-MOLECULE MICROSCOPY ASSAYS;

ENZYMES;

ADENOSINE TRIPHOSPHATE; KINESIN; KINESIN 13; MOLECULAR MOTOR; PROTEIN MCAK; UNCLASSIFIED DRUG; KIF2C PROTEIN, HUMAN; DNA; ENZYME; MCAK PROTEIN;

DIFFUSION; DNA; ENZYME; MICROSCOPY; PROTEIN; BIOASSAY; HYDROLYSIS; KINETICS; REGULATORY APPROACH;

ANIMAL CELL; ARTICLE; ASSAY; BINDING SITE; CATALYSIS; CELL DIVISION; DEPOLYMERIZATION; DIFFUSION COEFFICIENT; DYNAMICS; ENZYME BINDING; HYDROSALPINX; INTERPHASE; MICROSCOPY; MICROTUBULE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; REACTION ANALYSIS; BIOLOGICAL MODEL; CHEMISTRY; DIFFUSION; ENZYME SPECIFICITY; HUMAN; HYDROLYSIS; KINETICS; METABOLISM; MOLECULE;

ADENOSINE TRIPHOSPHATE; DIFFUSION; HUMANS; HYDROLYSIS; KINESIN; KINETICS; MICROTUBULES; MODELS, BIOLOGICAL; SUBSTRATE SPECIFICITY;

EID: 33646950699     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04736     Document Type: Article

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