The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3396-3400

  Alonso De Diego, Sergio A ^a   Gutiérrez Rodríguez, Marta ^a   Pérez de Vega, M Jesús ^a   González Muñiz, Rosario ^a   Herranz, Rosario ^a   Martín Martínez, Mercedes ^a   Cenarruzabeitia, Edurne ^d   Frechilla, Diana ^c,d   Río, Joaquín Del ^c,d   Jimeno, M Luisa ^b   García López, M Teresa ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b CSIC Centro de Quimica Organica Lora Tamayo CENQUIOR   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Glutamate receptors binding; GPE; Neuroprotection; Peptidomimetics; Tripeptides

Indexed keywords

GLUTAMATE RECEPTOR; GLYCYLPROLYLGLUTAMIC ACID DERIVATIVE; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; DRUG SYNTHESIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; RAT;

ANIMALS; BINDING, COMPETITIVE; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PROTEIN BINDING; RATS; RECEPTORS, GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646948506     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.033     Document Type: Article

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