XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice

Experimental Cell Research

Volumn 312, Issue 10, 2006, Pages 1890-1898

  Wootz, Hanna ^a   Hansson, Inga ^a   Korhonen, Laura ^a,b   Lindholm, Dan ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

ALS; Calpain; Calpastatin; Caspase 12; ER stress; Transgenic mice; XIAP

Indexed keywords

CALPAIN; CALPASTATIN; CASPASE 12; INHIBITOR OF APOPTOSIS PROTEIN 2; THY 1 ANTIGEN; X LINKED INHIBITOR OF APOPTOSIS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SPINAL CORD; SPINAL CORD NERVE CELL; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 33646943803     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.02.021     Document Type: Article

References (37)

1. Bruijn L.I., Miller T.M., and Cleveland D.W. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu. Rev. Neurosci. 27 (2004) 723-749
2. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., and Deng H.X. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (1993) 59-62
3. Gurney M.E. Transgenic-mouse model of amyotrophic lateral sclerosis. N. Engl. J. Med. 331 (1994) 1721-1722
4. Reaume A.G., Elliott J.L., Hoffman E.K., Kowall N.W., Ferrante R.J., Siwek D.F., Wilcox H.M., Flood D.G., Beal M.F., Brown Jr. R.H., Scott R.W., and Snider W.D. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13 (1996) 43-47
5. Ekegren T., Grundstrom E., Lindholm D., and Aquilonius S.M. Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons. Acta Neurol. Scand. 100 (1999) 317-321
6. Li M., Ona V.O., Guegan C., Chen M., Jackson-Lewis V., Andrews L.J., Olszewski A.J., Stieg P.E., Lee J.P., Przedborski S., and Friedlander R.M. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288 (2000) 335-339
7. Pasinelli P., Houseweart M.K., Brown Jr. R.H., and Cleveland D.W. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 13901-13906
8. Inoue H., Tsukita K., Iwasato T., Suzuki Y., Tomioka M., Tateno M., Nagao M., Kawata A., Saido T.C., Miura M., Misawa H., Hohara S., and Takahashi R. The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J. 22 (2003) 6665-6674
9. Guegan C., Vila M., Rosoklija G., Hays A.P., and Przedborski S. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. J. Neurosci. 21 (2001) 6569-6576
10. Wootz H., Hansson I., Korhonen L., Näpänkangas U., and Lindholm D. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem. Biophys. Res. Commun. 322 (2004) 281-286
11. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., and Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403 (2000) 98-103
12. Morishima N., Nakanishi K., Takenouchi H., Shibata T., and Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277 (2002) 34287-34294
13. Rao R.V., Castro-Obregon S., Frankowski H., Schuler M., Stoka V., Del Rio G., Bredesen D.E., and Ellerby H.M. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J. Biol. Chem. 277 (2002) 21836-21842
14. Trapp T., Korhonen L., Besselmann M., Martinez R., Mercer E.A., and Lindholm D. Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. Mol. Cell. Neurosci. 23 (2003) 302-313
15. Korhonen L., Näpänkangas U., Steen H., Chen Y., Martinez R., and Lindholm D. Differential regulation of X-chromosome-linked inhibitor of apoptosis protein (XIAP) and caspase-3 by NMDA in developing hippocampal neurons; involvement of the mitochondrial pathway in NMDA-mediated neuronal survival. Exp. Cell Res. 295 (2004) 290-299
16. Korhonen L., Belluardo N., and Lindholm D. Regulation of X-chromosome-linked inhibitor of apoptosis protein in kainic acid-induced neuronal death in the rat hippocampus. Mol. Cell. Neurosci. 17 (2001) 364-372
17. Deveraux Q.L., Takahashi R., Salvesen G.S., and Reed J.C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388 (1997) 300-304
18. Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., and Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16 (1997) 6914-6925
19. Liston P., Lefebvre C., Fong W.G., Xuan J.Y., and Korneluk R.G. Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. Genomics 46 (1997) 495-503
20. Belluardo N., Korhonen L., Mudo G., and Lindholm D. Neuronal expression and regulation of rat inhibitor of apoptosis protein-2 by kainic acid in the rat brain. Eur. J. Neurosci. 15 (2002) 87-100
21. Ishigaki S., Liang Y., Yamamoto M., Niwa J., Ando Y., Yoshihara T., Takeuchi H., Doyu M., and Sobue G. X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. J. Neurochem. 82 (2002) 576-584
22. Caroni P. Overexpression of growth-associated proteins in the neurons of adult transgenic mice. J. Neurosci. Methods 71 (1997) 3-9
23. Nakagawa T., and Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 150 (2000) 887-894
24. Wang K.K. Calpain and caspase: can you tell the difference?. Trends Neurosci. 23 (2000) 20-26
25. Breckenridge D.G., Germain M., Mathai J.P., Nguyen M., and Shore G.C. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22 (2003) 8608-8618
26. Lindholm D., Wootz H., and Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differ. 13 (2006) 385-392
27. Blomgren K., Zhu C., Wang X., Karlsson J.O., Leverin A.L., Bahr B.A., Mallard C., and Hagberg H. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis?". J. Biol. Chem. 276 (2001) 10191-10198
28. Lankiewicz S., Marc Luetjens C., Truc Bui N., Krohn A.J., Poppe M., Cole G.M., Saido T.C., and Prehn J.H. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J. Biol. Chem. 275 (2000) 17064-17071
29. Porn-Ares I.M., Samali A., and Orrenius S. Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell Death Differ. 5 (1998) 1028-1033
30. Pramatarova A., Laganiere J., Roussel J., Brisebois K., and Rouleau G.A. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J. Neurosci. 21 (2001) 3369-3374
31. Lino M.M., Schneider C., and Caroni P. Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease. J. Neurosci. 22 (2002) 482-532
32. Clement A.M., Nguyen M.D., Roberts E.A., Garcia M.L., Boillee S., Rule M., McMahon A.P., Doucette W., Siwek D., Ferrante R.J., Brown Jr. R.H., Julien J.P., Goldstein L.S., and Cleveland D.W. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302 (2003) 113-117
33. Rothe M., Pan M.G., Henzel W.J., Ayres T.M., and Goeddel D.V. The TNFR2-TRAF signalling complex contains two novel proteins related to baculovirus inhibitor of apoptosis. Cell 13 (1995) 1243-1252
34. Wang X., Zhu C., Wang X., Hagberg H., Korhonen L., Sandberg M., Lindholm D., and Blomgren K. X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia. Neurobiol. Dis. 16 (2004) 179-189
35. Kang S.J., Sanchez I., Jing N., and Yuan J. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 23 (2003) 5455-5560
36. Obeng E.A., and Boise L.H. Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J. Biol. Chem. 280 (2005) 29578-29587
37. Di Sano F., Ferraro E., Tufi R., Achsel T., Piacentini M., and Cecconi F. Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism. J. Biol. Chem. 281 (2006) 2693-2700